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Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a meta-analysis.
Eur J Epidemiol 2012; 27(12):895-901EJ

Abstract

Prospective studies of long-chain omega-3 polyunsaturated fatty acids (PUFA) in relation to stroke have yielded inconsistent results. The authors conducted a meta-analysis of prospective studies to summarize available evidence regarding the relation between long-chain omega-3 PUFA intake and stroke. Pertinent studies were identified by searching PubMed and Embase databases to November 1, 2012 and by reviewing the reference lists of relevant publications. Prospective studies that provided relative risks (RRs) with 95 % confidence intervals (CIs) for the association between dietary long-chain omega-3 PUFA intake and stroke were eligible. A random-effects model was used to combine study-specific results. Eight prospective studies, with 5238 stroke events among 242,076 participants, were included in the meta-analysis. The combined RR of total stroke was 0.90 (95 % CI, 0.81-1.01) for the highest versus lowest category of long-chain omega-3 PUFA intake, without heterogeneity among studies (P = 0.32). Results were similar for ischemic (RR, 0.82; 95 % CI, 0.71-0.94) and hemorrhagic stroke (RR, 0.80; 95 % CI, 0.55-1.15). A statistically significant reduction in total stroke risk was observed in women (RR, 0.80; 95 % CI, 0.65-0.99). This meta-analysis showed no overall association between omega-3 PUFA intake and stroke, but suggests that women might benefit from a higher intake of these PUFAs.

Authors+Show Affiliations

Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-17177, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23179632

Citation

Larsson, Susanna C., et al. "Long-chain Omega-3 Polyunsaturated Fatty Acids and Risk of Stroke: a Meta-analysis." European Journal of Epidemiology, vol. 27, no. 12, 2012, pp. 895-901.
Larsson SC, Orsini N, Wolk A. Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a meta-analysis. Eur J Epidemiol. 2012;27(12):895-901.
Larsson, S. C., Orsini, N., & Wolk, A. (2012). Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a meta-analysis. European Journal of Epidemiology, 27(12), pp. 895-901. doi:10.1007/s10654-012-9748-9.
Larsson SC, Orsini N, Wolk A. Long-chain Omega-3 Polyunsaturated Fatty Acids and Risk of Stroke: a Meta-analysis. Eur J Epidemiol. 2012;27(12):895-901. PubMed PMID: 23179632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a meta-analysis. AU - Larsson,Susanna C, AU - Orsini,Nicola, AU - Wolk,Alicja, Y1 - 2012/11/20/ PY - 2012/09/11/received PY - 2012/11/05/accepted PY - 2012/11/27/entrez PY - 2012/11/28/pubmed PY - 2013/4/4/medline SP - 895 EP - 901 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 27 IS - 12 N2 - Prospective studies of long-chain omega-3 polyunsaturated fatty acids (PUFA) in relation to stroke have yielded inconsistent results. The authors conducted a meta-analysis of prospective studies to summarize available evidence regarding the relation between long-chain omega-3 PUFA intake and stroke. Pertinent studies were identified by searching PubMed and Embase databases to November 1, 2012 and by reviewing the reference lists of relevant publications. Prospective studies that provided relative risks (RRs) with 95 % confidence intervals (CIs) for the association between dietary long-chain omega-3 PUFA intake and stroke were eligible. A random-effects model was used to combine study-specific results. Eight prospective studies, with 5238 stroke events among 242,076 participants, were included in the meta-analysis. The combined RR of total stroke was 0.90 (95 % CI, 0.81-1.01) for the highest versus lowest category of long-chain omega-3 PUFA intake, without heterogeneity among studies (P = 0.32). Results were similar for ischemic (RR, 0.82; 95 % CI, 0.71-0.94) and hemorrhagic stroke (RR, 0.80; 95 % CI, 0.55-1.15). A statistically significant reduction in total stroke risk was observed in women (RR, 0.80; 95 % CI, 0.65-0.99). This meta-analysis showed no overall association between omega-3 PUFA intake and stroke, but suggests that women might benefit from a higher intake of these PUFAs. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/23179632/Long_chain_omega_3_polyunsaturated_fatty_acids_and_risk_of_stroke:_a_meta_analysis_ L2 - https://doi.org/10.1007/s10654-012-9748-9 DB - PRIME DP - Unbound Medicine ER -