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Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats.
Phytother Res. 2013 Oct; 27(10):1489-94.PR

Abstract

A comparative oral pharmacokinetic study of five anthraquinones (aloe-emodin, emodin, rhein, chrysophanol and physcion) from the extract of Rheum palmatum L. was performed in normal and thrombotic focal cerebral ischemia (TFCI)-induced rats. The plasma samples were clarified through solid phase extraction prior to simultaneous determination of the anthraquinones with a validated high-performance liquid chromatography-fluorescence system. The results indicated that the Cmax, t(1/2) and AUC(0-t), of aloe-emodin, rhein, emodin and chrysophanol in TFCI-induced rats were nearly double, whereas the CL values were remarkably decreased (p < 0.05) over those of the normal rats. The plasma drug concentration-time data of five anthraquinones to rats fitted a two-compartment open model. The five anthraquinones in rat plasma were absorbed quickly and eliminated slowly in both groups. The obtained results could be helpful for evaluating the impact of the efficacy and safety of the drug in clinical applications.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Feng SX
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, China; College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, 450008, China.
Li JS
No affiliation info available
Qu LB
No affiliation info available
Shi YM
No affiliation info available
Zhao D
No affiliation info available

MeSH

AnimalsAnthraquinonesBrain IschemiaChromatography, High Pressure LiquidDrugs, Chinese HerbalEmodinMalePlant ExtractsRatsRats, Sprague-DawleyRheum

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23180574

Citation

Feng, Su-xiang, et al. "Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-induced Rats." Phytotherapy Research : PTR, vol. 27, no. 10, 2013, pp. 1489-94.
Feng SX, Li JS, Qu LB, et al. Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats. Phytother Res. 2013;27(10):1489-94.
Feng, S. X., Li, J. S., Qu, L. B., Shi, Y. M., & Zhao, D. (2013). Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats. Phytotherapy Research : PTR, 27(10), 1489-94. https://doi.org/10.1002/ptr.4890
Feng SX, et al. Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-induced Rats. Phytother Res. 2013;27(10):1489-94. PubMed PMID: 23180574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats. AU - Feng,Su-xiang, AU - Li,Jian-sheng, AU - Qu,Ling-bo, AU - Shi,Yan-mei, AU - Zhao,Di, Y1 - 2012/11/26/ PY - 2012/05/20/received PY - 2012/10/22/revised PY - 2012/10/24/accepted PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2014/4/15/medline KW - anthraquinones KW - normal rats KW - pharmacokinetics comparison KW - rhubarb extract KW - thrombotic focal cerebral ischemia-induced rats SP - 1489 EP - 94 JF - Phytotherapy research : PTR JO - Phytother Res VL - 27 IS - 10 N2 - A comparative oral pharmacokinetic study of five anthraquinones (aloe-emodin, emodin, rhein, chrysophanol and physcion) from the extract of Rheum palmatum L. was performed in normal and thrombotic focal cerebral ischemia (TFCI)-induced rats. The plasma samples were clarified through solid phase extraction prior to simultaneous determination of the anthraquinones with a validated high-performance liquid chromatography-fluorescence system. The results indicated that the Cmax, t(1/2) and AUC(0-t), of aloe-emodin, rhein, emodin and chrysophanol in TFCI-induced rats were nearly double, whereas the CL values were remarkably decreased (p < 0.05) over those of the normal rats. The plasma drug concentration-time data of five anthraquinones to rats fitted a two-compartment open model. The five anthraquinones in rat plasma were absorbed quickly and eliminated slowly in both groups. The obtained results could be helpful for evaluating the impact of the efficacy and safety of the drug in clinical applications. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/23180574/Comparative_pharmacokinetics_of_five_rhubarb_anthraquinones_in_normal_and_thrombotic_focal_cerebral_ischemia_induced_rats_ DB - PRIME DP - Unbound Medicine ER -