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Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats.

Abstract

Probiotic bacteria and phytosterols are natural hypocholesterolemic agents with potential cardiovascular benefits. Accordingly, the present study was conducted to evaluate the effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. Mixed probiotics treatment consisted of 8 probiotic strains: 2 strains of each of Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus gasseri, and Lactobacillus reuteri. The rats were fed for 8 wk with the given treatments in addition to a high-fat-high-cholesterol basal diet to induce hypercholesterolemia. Results showed that supplementation significantly reduced serum total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol, and triglycerides compared with the controls. The symbiotic treatment was more effective in lowering LDL-C, whereas mixed probiotics treatment more effectively lowered serum total cholesterol and LDL-C than the phytosterol-containing treatment. The phytosterol-containing treatments induced the increased activity of thyroid glands, as evident by elevated levels of serum total thyroxine, total triiodothyronine, and free triiodothyronine. In conclusion, the lipid profile can effectively be reduced to lower the incidence of cardiovascular disease using combinations of Lactobacillus-based probiotics and phytosterols in functional foods.

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  • Authors+Show Affiliations

    ,

    Department of Food Science, Al-Balqa Applied University, 19117, Salt, Jordan. saddam_awaisheh@yahoo.com

    , , , ,

    Source

    Journal of dairy science 96:1 2013 Jan pg 9-15

    MeSH

    Animals
    Cholesterol
    Cholesterol, Dietary
    Dietary Supplements
    Drug Therapy, Combination
    Hypercholesterolemia
    Lactobacillus
    Lipids
    Lipoproteins, HDL
    Lipoproteins, LDL
    Liver
    Male
    Phytosterols
    Probiotics
    Rats
    Rats, Sprague-Dawley
    Thyroid Hormones
    Thyroxine
    Triglycerides
    Triiodothyronine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23182355

    Citation

    Awaisheh, S S., et al. "Effect of Supplementation of Probiotics and Phytosterols Alone or in Combination On Serum and Hepatic Lipid Profiles and Thyroid Hormones of Hypercholesterolemic Rats." Journal of Dairy Science, vol. 96, no. 1, 2013, pp. 9-15.
    Awaisheh SS, Khalifeh MS, Al-Ruwaili MA, et al. Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. J Dairy Sci. 2013;96(1):9-15.
    Awaisheh, S. S., Khalifeh, M. S., Al-Ruwaili, M. A., Khalil, O. M., Al-Ameri, O. H., & Al-Groom, R. (2013). Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. Journal of Dairy Science, 96(1), pp. 9-15. doi:10.3168/jds.2012-5442.
    Awaisheh SS, et al. Effect of Supplementation of Probiotics and Phytosterols Alone or in Combination On Serum and Hepatic Lipid Profiles and Thyroid Hormones of Hypercholesterolemic Rats. J Dairy Sci. 2013;96(1):9-15. PubMed PMID: 23182355.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. AU - Awaisheh,S S, AU - Khalifeh,M S, AU - Al-Ruwaili,M A, AU - Khalil,O M, AU - Al-Ameri,O H, AU - Al-Groom,R, Y1 - 2012/11/22/ PY - 2012/02/16/received PY - 2012/10/11/accepted PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2013/6/6/medline SP - 9 EP - 15 JF - Journal of dairy science JO - J. Dairy Sci. VL - 96 IS - 1 N2 - Probiotic bacteria and phytosterols are natural hypocholesterolemic agents with potential cardiovascular benefits. Accordingly, the present study was conducted to evaluate the effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. Mixed probiotics treatment consisted of 8 probiotic strains: 2 strains of each of Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus gasseri, and Lactobacillus reuteri. The rats were fed for 8 wk with the given treatments in addition to a high-fat-high-cholesterol basal diet to induce hypercholesterolemia. Results showed that supplementation significantly reduced serum total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol, and triglycerides compared with the controls. The symbiotic treatment was more effective in lowering LDL-C, whereas mixed probiotics treatment more effectively lowered serum total cholesterol and LDL-C than the phytosterol-containing treatment. The phytosterol-containing treatments induced the increased activity of thyroid glands, as evident by elevated levels of serum total thyroxine, total triiodothyronine, and free triiodothyronine. In conclusion, the lipid profile can effectively be reduced to lower the incidence of cardiovascular disease using combinations of Lactobacillus-based probiotics and phytosterols in functional foods. SN - 1525-3198 UR - https://www.unboundmedicine.com/medline/citation/23182355/Effect_of_supplementation_of_probiotics_and_phytosterols_alone_or_in_combination_on_serum_and_hepatic_lipid_profiles_and_thyroid_hormones_of_hypercholesterolemic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(12)00851-X DB - PRIME DP - Unbound Medicine ER -