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Cognitive reserve as a predictor of two year neuropsychological performance in early onset first-episode schizophrenia.



The concept of cognitive reserve (CR) has been defined as individual differences in the efficient utilization of brain networks which allow some people to cope better than others with brain pathology. CR has been developed mainly in the field of aging and dementia after it was observed that there appears to be no direct relationship between the degree of brain pathology and the severity of clinical manifestations of this damage. The present study applies the concept of CR to a sample of children and adolescents with a first episode of schizophrenia, aiming to assess the possible influence of CR on neuropsychological performance after two year follow-up, controlling for the influence of clinical psychopathology.


35 patients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder (SSD) and 98 healthy controls (HC) matched for age and gender were included. CR was assessed at baseline, taking into account premorbid IQ, educational-occupational level and leisure activities. Clinical and neuropsychological assessments were completed by all patients at two year follow-up.


The CR proxy was able to predict working memory and attention at two year follow-up. Verbal memory and cognitive flexibility were not predicted by any of the variables included in the regression model. The SSD group obtained lower scores than HC on CR. CR measures correctly classified 79.8% of the sample as being SSD or HC.


Lower scores on CR were observed in SSD than in HC and the CR measure correctly classified a high percentage of the sample into the two groups. CR may predict SSD performance on working memory and attention tasks.


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  • Authors+Show Affiliations


    Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.

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    Schizophrenia research 143:1 2013 Jan pg 125-31


    Case-Control Studies
    Cognition Disorders
    Cognitive Reserve
    Factor Analysis, Statistical
    Linear Models
    Longitudinal Studies
    Memory, Short-Term
    Neuropsychological Tests
    Predictive Value of Tests
    Psychiatric Status Rating Scales
    Psychotic Disorders
    Schizophrenic Psychology

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't



    PubMed ID