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[Vitamin D deficiency in a Spanish cohort of patients with chronic kidney disease].
Med Clin (Barc). 2013 Oct 19; 141(8):338-42.MC

Abstract

BACKGROUND AND OBJECTIVE

Vitamin D (25-OH-D3) deficiency is an emerging global health problem. Chronic kidney disease (CKD) patients have a higher risk of this deficiency. We aimed to determine the prevalence of 25-OH-D3 deficiency in a cohort of CKD patients in an urban area of Spain and its relationship with cardiovascular disease (CVD).

PATIENTS AND METHODS

We evaluated the prevalence of 25-OH-D3 deficiency in 751 incident patients referred to our outpatient clinic (male gender 59.3%, mean age 67.2 [± 15] years, mean GFR (MDRD-4) 47.9 ± 25.5 ml/min/1.73 m(2)) with different stages of CKD. We excluded end stage renal disease patients and with kidney transplant. Clinical data and biochemical parameters related to bone and mineral metabolism were recorded. Levels of 25-OH-D3< 15 ng/ml were considered to be deficient.

RESULTS

The mean 25-OH-D3 levels were 17.06 [± 12.93] ng/ml. Only 10% of our patients had adequate 25-OH-D3 levels (>30 ng/ml) and 51% showed deficient levels. 25-OH-D3 deficiency worsened with the progression of CKD (P<.05). Elderly people (P=.001), female gender (P=.02), and diabetes (P=.03) were closely associated with 25-OH-D3 deficiency. 25-OH-D3 deficiency was inversely associated with serum PTH (P=.02), and directly associated with serum calcium (P<.004). Patients with a history of CVD had lower 25-OH-D3 levels (P=.038).

CONCLUSIONS

25-OH-D3 deficiency has a high prevalence in CKD patients, and the severity increases with the progression of kidney disease. Elderly, women and diabetic patients have a higher risk of 25-OH-D3 deficiency. 25-OH-D3 deficiency was related to higher levels of PTH and lower serum calcium.

Authors+Show Affiliations

Servicio de Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: claudiayustelozano@yahoo.es.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

spa

PubMed ID

23182534

Citation

Yuste, Claudia, et al. "[Vitamin D Deficiency in a Spanish Cohort of Patients With Chronic Kidney Disease]." Medicina Clinica, vol. 141, no. 8, 2013, pp. 338-42.
Yuste C, García De Vinuesa S, Goicoechea M, et al. [Vitamin D deficiency in a Spanish cohort of patients with chronic kidney disease]. Med Clin (Barc). 2013;141(8):338-42.
Yuste, C., García De Vinuesa, S., Goicoechea, M., Barraca, D., Panizo, N., Quiroga, B., & Luño, J. (2013). [Vitamin D deficiency in a Spanish cohort of patients with chronic kidney disease]. Medicina Clinica, 141(8), 338-42. https://doi.org/10.1016/j.medcli.2012.07.026
Yuste C, et al. [Vitamin D Deficiency in a Spanish Cohort of Patients With Chronic Kidney Disease]. Med Clin (Barc). 2013 Oct 19;141(8):338-42. PubMed PMID: 23182534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vitamin D deficiency in a Spanish cohort of patients with chronic kidney disease]. AU - Yuste,Claudia, AU - García De Vinuesa,Soledad, AU - Goicoechea,Marian, AU - Barraca,Daniel, AU - Panizo,Nayara, AU - Quiroga,Borja, AU - Luño,Jose, Y1 - 2012/11/23/ PY - 2012/03/24/received PY - 2012/07/12/revised PY - 2012/07/19/accepted PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2014/6/7/medline KW - 25-hidroxivitamina D KW - 25-hydroxyvitamin D KW - Cardiovascular disease KW - Chronic kidney disease KW - Deficiencia de vitamina D KW - Enfermedad cardiovascular KW - Enfermedad renal crónica KW - Vitamin D deficiency SP - 338 EP - 42 JF - Medicina clinica JO - Med Clin (Barc) VL - 141 IS - 8 N2 - BACKGROUND AND OBJECTIVE: Vitamin D (25-OH-D3) deficiency is an emerging global health problem. Chronic kidney disease (CKD) patients have a higher risk of this deficiency. We aimed to determine the prevalence of 25-OH-D3 deficiency in a cohort of CKD patients in an urban area of Spain and its relationship with cardiovascular disease (CVD). PATIENTS AND METHODS: We evaluated the prevalence of 25-OH-D3 deficiency in 751 incident patients referred to our outpatient clinic (male gender 59.3%, mean age 67.2 [± 15] years, mean GFR (MDRD-4) 47.9 ± 25.5 ml/min/1.73 m(2)) with different stages of CKD. We excluded end stage renal disease patients and with kidney transplant. Clinical data and biochemical parameters related to bone and mineral metabolism were recorded. Levels of 25-OH-D3< 15 ng/ml were considered to be deficient. RESULTS: The mean 25-OH-D3 levels were 17.06 [± 12.93] ng/ml. Only 10% of our patients had adequate 25-OH-D3 levels (>30 ng/ml) and 51% showed deficient levels. 25-OH-D3 deficiency worsened with the progression of CKD (P<.05). Elderly people (P=.001), female gender (P=.02), and diabetes (P=.03) were closely associated with 25-OH-D3 deficiency. 25-OH-D3 deficiency was inversely associated with serum PTH (P=.02), and directly associated with serum calcium (P<.004). Patients with a history of CVD had lower 25-OH-D3 levels (P=.038). CONCLUSIONS: 25-OH-D3 deficiency has a high prevalence in CKD patients, and the severity increases with the progression of kidney disease. Elderly, women and diabetic patients have a higher risk of 25-OH-D3 deficiency. 25-OH-D3 deficiency was related to higher levels of PTH and lower serum calcium. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/23182534/[Vitamin_D_deficiency_in_a_Spanish_cohort_of_patients_with_chronic_kidney_disease]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(12)00806-8 DB - PRIME DP - Unbound Medicine ER -