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Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.
Behav Brain Res. 2013 Mar 01; 240:91-4.BB

Abstract

Cannabinoid type 1 receptors (CB1r) are an important modulatory site for emotional behavior. However, little is known on the effects of CB1r ligands on emotionality aspects of primates, even with their highly similar behavioral response and receptor density/distribution as humans. Thus, we analyzed the effects of the CB1r agonist WIN 55,212-2 (WIN; 1mg/kg) and the antagonist AM 251 (AM; 2mg/kg), systemically administered prior to a single brief (15 min) exposure to a novel open-field (OF) environment, on the behavior of individually tested adult black tufted-ear marmosets. Both WIN- and AM-treated subjects, compared to vehicle controls, had significantly lower rates of long (contact) calls and exploration, while higher levels of vigilance-related behaviors (scan/glance); these are indicators of anxiolysis in this setup. Changes in locomotion were not detected. However, in the vehicle and AM-groups, sojourn in the peripheral zone of the OF was significantly higher than in its central region. WIN-treated marmosets spent an equivalent amount of time in both zones. Therefore, activation or blockade CB1r function prior to a short and individual exposure to an unfamiliar environment exerted a significant and complex influence on different behavioral indicators of anxiety in these monkeys (i.e., a partially overlapping anxiolytic-like profile). AM 251, however, has no anxiolytic effect when the time spent in the center of the OF is considered. This is a major difference when compared to the WIN-treated group. Data were compared to the response profile reported in other pre-clinical (rodent) and clinical studies.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, 70910-900 Brasilia, DF, Brazil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23183218

Citation

Cagni, Priscila, and Marilia Barros. "Cannabinoid Type 1 Receptor Ligands WIN 55,212-2 and AM 251 Alter Anxiety-like Behaviors of Marmoset Monkeys in an Open-field Test." Behavioural Brain Research, vol. 240, 2013, pp. 91-4.
Cagni P, Barros M. Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test. Behav Brain Res. 2013;240:91-4.
Cagni, P., & Barros, M. (2013). Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test. Behavioural Brain Research, 240, 91-4. https://doi.org/10.1016/j.bbr.2012.11.018
Cagni P, Barros M. Cannabinoid Type 1 Receptor Ligands WIN 55,212-2 and AM 251 Alter Anxiety-like Behaviors of Marmoset Monkeys in an Open-field Test. Behav Brain Res. 2013 Mar 1;240:91-4. PubMed PMID: 23183218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test. AU - Cagni,Priscila, AU - Barros,Marilia, Y1 - 2012/11/23/ PY - 2012/09/10/received PY - 2012/11/08/revised PY - 2012/11/12/accepted PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2013/6/19/medline SP - 91 EP - 4 JF - Behavioural brain research JO - Behav Brain Res VL - 240 N2 - Cannabinoid type 1 receptors (CB1r) are an important modulatory site for emotional behavior. However, little is known on the effects of CB1r ligands on emotionality aspects of primates, even with their highly similar behavioral response and receptor density/distribution as humans. Thus, we analyzed the effects of the CB1r agonist WIN 55,212-2 (WIN; 1mg/kg) and the antagonist AM 251 (AM; 2mg/kg), systemically administered prior to a single brief (15 min) exposure to a novel open-field (OF) environment, on the behavior of individually tested adult black tufted-ear marmosets. Both WIN- and AM-treated subjects, compared to vehicle controls, had significantly lower rates of long (contact) calls and exploration, while higher levels of vigilance-related behaviors (scan/glance); these are indicators of anxiolysis in this setup. Changes in locomotion were not detected. However, in the vehicle and AM-groups, sojourn in the peripheral zone of the OF was significantly higher than in its central region. WIN-treated marmosets spent an equivalent amount of time in both zones. Therefore, activation or blockade CB1r function prior to a short and individual exposure to an unfamiliar environment exerted a significant and complex influence on different behavioral indicators of anxiety in these monkeys (i.e., a partially overlapping anxiolytic-like profile). AM 251, however, has no anxiolytic effect when the time spent in the center of the OF is considered. This is a major difference when compared to the WIN-treated group. Data were compared to the response profile reported in other pre-clinical (rodent) and clinical studies. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/23183218/Cannabinoid_type_1_receptor_ligands_WIN_55212_2_and_AM_251_alter_anxiety_like_behaviors_of_marmoset_monkeys_in_an_open_field_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00740-1 DB - PRIME DP - Unbound Medicine ER -