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Comparison of the effectiveness of trivalent inactivated influenza vaccine and live, attenuated influenza vaccine in preventing influenza-like illness among US military service members, 2006-2009.
Clin Infect Dis 2013; 56(1):11-9CI

Abstract

BACKGROUND

Influenza is a significant cause of morbidity, and vaccination is the preferred preventive strategy. Data regarding the preferred influenza vaccine type among adults are limited.

METHODS

The effectiveness of 2 currently available influenza vaccines LAIV and TIV in preventing influenza-like illness (ILI) was compared among US military members (aged 18-49 years) during 3 consecutive influenza seasons (2006-2009). ILI, influenza, and pneumonia events post-vaccination were compared between vaccine types using Cox proportional hazard models adjusted for sociodemographic factors, occupation, and geographic area.

RESULTS

A total of 41 670 vaccination events were evaluated, including 28 929 during 2 "well-matched" seasons (2006-2007 and 2008-2009: LAIV n = 22 734, TIV n = 6195) and 12 741 during a suboptimally matched season due to mild antigenic drift (2007-2008: LAIV n = 9447, TIV n = 3294). ILI crude incidence rates for LAIV and TIV were 139 and 127 cases per 1000 person-seasons for the well-matched seasons, respectively, and 150 and 165 cases per 1000 person-seasons for the suboptimally matched season, respectively. In the multivariable models, there were no differences in ILI events by vaccine type (well-matched seasons: hazard ratio [HR], 0.97; 95% confidence interval [CI], .90-1.06; suboptimally matched season: HR, 1.00; 95% CI, .90-1.11). There were also no differences in influenza and/or pneumonia events by vaccine group.

CONCLUSIONS

Between 2006 and 2009, TIV and LAIV had similar effectiveness in preventing ILI and influenza/pneumonia events among healthy adults.

Authors+Show Affiliations

Department of Deployment Health Research, Naval Health Research Center, San Diego, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23183869

Citation

Phillips, Christopher J., et al. "Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-like Illness Among US Military Service Members, 2006-2009." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 56, no. 1, 2013, pp. 11-9.
Phillips CJ, Woolpert T, Sevick C, et al. Comparison of the effectiveness of trivalent inactivated influenza vaccine and live, attenuated influenza vaccine in preventing influenza-like illness among US military service members, 2006-2009. Clin Infect Dis. 2013;56(1):11-9.
Phillips, C. J., Woolpert, T., Sevick, C., Faix, D., Blair, P. J., & Crum-Cianflone, N. F. (2013). Comparison of the effectiveness of trivalent inactivated influenza vaccine and live, attenuated influenza vaccine in preventing influenza-like illness among US military service members, 2006-2009. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 56(1), pp. 11-9. doi:10.1093/cid/cis860.
Phillips CJ, et al. Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-like Illness Among US Military Service Members, 2006-2009. Clin Infect Dis. 2013;56(1):11-9. PubMed PMID: 23183869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effectiveness of trivalent inactivated influenza vaccine and live, attenuated influenza vaccine in preventing influenza-like illness among US military service members, 2006-2009. AU - Phillips,Christopher J, AU - Woolpert,Tabitha, AU - Sevick,Carter, AU - Faix,Dennis, AU - Blair,Patrick J, AU - Crum-Cianflone,Nancy F, Y1 - 2012/11/26/ PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2013/6/20/medline SP - 11 EP - 9 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 56 IS - 1 N2 - BACKGROUND: Influenza is a significant cause of morbidity, and vaccination is the preferred preventive strategy. Data regarding the preferred influenza vaccine type among adults are limited. METHODS: The effectiveness of 2 currently available influenza vaccines LAIV and TIV in preventing influenza-like illness (ILI) was compared among US military members (aged 18-49 years) during 3 consecutive influenza seasons (2006-2009). ILI, influenza, and pneumonia events post-vaccination were compared between vaccine types using Cox proportional hazard models adjusted for sociodemographic factors, occupation, and geographic area. RESULTS: A total of 41 670 vaccination events were evaluated, including 28 929 during 2 "well-matched" seasons (2006-2007 and 2008-2009: LAIV n = 22 734, TIV n = 6195) and 12 741 during a suboptimally matched season due to mild antigenic drift (2007-2008: LAIV n = 9447, TIV n = 3294). ILI crude incidence rates for LAIV and TIV were 139 and 127 cases per 1000 person-seasons for the well-matched seasons, respectively, and 150 and 165 cases per 1000 person-seasons for the suboptimally matched season, respectively. In the multivariable models, there were no differences in ILI events by vaccine type (well-matched seasons: hazard ratio [HR], 0.97; 95% confidence interval [CI], .90-1.06; suboptimally matched season: HR, 1.00; 95% CI, .90-1.11). There were also no differences in influenza and/or pneumonia events by vaccine group. CONCLUSIONS: Between 2006 and 2009, TIV and LAIV had similar effectiveness in preventing ILI and influenza/pneumonia events among healthy adults. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/23183869/Comparison_of_the_effectiveness_of_trivalent_inactivated_influenza_vaccine_and_live_attenuated_influenza_vaccine_in_preventing_influenza_like_illness_among_US_military_service_members_2006_2009_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cis860 DB - PRIME DP - Unbound Medicine ER -