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100 years of Lewy pathology.
Nat Rev Neurol. 2013 01; 9(1):13-24.NR

Abstract

In 1817, James Parkinson described the symptoms of the shaking palsy, a disease that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin Charcot. Parkinson expected that the publication of his monograph would lead to a rapid elucidation of the anatomical substrate of the shaking palsy; in the event, this process took almost a century. In 1912, Fritz Heinrich Lewy identified the protein aggregates that define Parkinson disease (PD) in some brain regions outside the substantia nigra. In 1919, Konstantin Nikolaevich Tretiakoff found similar aggregates in the substantia nigra and named them after Lewy. In the 1990s, α-synuclein was identified as the main constituent of the Lewy pathology, and its aggregation was shown to be central to PD, dementia with Lewy bodies, and multiple system atrophy. In 2003, a staging scheme for idiopathic PD was introduced, according to which α-synuclein pathology originates in the dorsal motor nucleus of the vagal nerve and progresses from there to other brain regions, including the substantia nigra. In this article, we review the relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders.

Authors+Show Affiliations

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. mg@mrc-lmb.cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article
Portrait
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23183883

Citation

Goedert, Michel, et al. "100 Years of Lewy Pathology." Nature Reviews. Neurology, vol. 9, no. 1, 2013, pp. 13-24.
Goedert M, Spillantini MG, Del Tredici K, et al. 100 years of Lewy pathology. Nat Rev Neurol. 2013;9(1):13-24.
Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013). 100 years of Lewy pathology. Nature Reviews. Neurology, 9(1), 13-24. https://doi.org/10.1038/nrneurol.2012.242
Goedert M, et al. 100 Years of Lewy Pathology. Nat Rev Neurol. 2013;9(1):13-24. PubMed PMID: 23183883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 100 years of Lewy pathology. AU - Goedert,Michel, AU - Spillantini,Maria Grazia, AU - Del Tredici,Kelly, AU - Braak,Heiko, Y1 - 2012/11/27/ PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2013/6/25/medline SP - 13 EP - 24 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 9 IS - 1 N2 - In 1817, James Parkinson described the symptoms of the shaking palsy, a disease that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin Charcot. Parkinson expected that the publication of his monograph would lead to a rapid elucidation of the anatomical substrate of the shaking palsy; in the event, this process took almost a century. In 1912, Fritz Heinrich Lewy identified the protein aggregates that define Parkinson disease (PD) in some brain regions outside the substantia nigra. In 1919, Konstantin Nikolaevich Tretiakoff found similar aggregates in the substantia nigra and named them after Lewy. In the 1990s, α-synuclein was identified as the main constituent of the Lewy pathology, and its aggregation was shown to be central to PD, dementia with Lewy bodies, and multiple system atrophy. In 2003, a staging scheme for idiopathic PD was introduced, according to which α-synuclein pathology originates in the dorsal motor nucleus of the vagal nerve and progresses from there to other brain regions, including the substantia nigra. In this article, we review the relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/23183883/100_years_of_Lewy_pathology_ L2 - https://doi.org/10.1038/nrneurol.2012.242 DB - PRIME DP - Unbound Medicine ER -