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Parental occupational exposure to engine exhausts and childhood brain tumors.
Int J Cancer. 2013 Jun 15; 132(12):2975-9.IJ

Abstract

Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. Since most CBTs are diagnosed before five years of age, prenatal exposure and early postnatal factors may be involved in their etiology. We investigated the association between CBT and parental occupational exposure to engine exhausts in an Australian population-based case-control study. Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for both maternal and paternal exposure in key time periods. Increased risks were observed for maternal exposure to diesel exhaust any time before the child's birth (OR 2.03, 95% CI 1.09-3.81) and paternal exposure around the time of the child's conception (OR 1.62, 95% CI 1.12-2.34). No clear associations with other engine exhausts were found. Our results suggest that parental occupational exposure to diesel exhaust may increase the risk of CBT.

Authors+Show Affiliations

Western Australian Institute for Medical Research, University of Western Australia, Perth, WA, Australia. susan.peters@uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23184618

Citation

Peters, Susan, et al. "Parental Occupational Exposure to Engine Exhausts and Childhood Brain Tumors." International Journal of Cancer, vol. 132, no. 12, 2013, pp. 2975-9.
Peters S, Glass DC, Reid A, et al. Parental occupational exposure to engine exhausts and childhood brain tumors. Int J Cancer. 2013;132(12):2975-9.
Peters, S., Glass, D. C., Reid, A., de Klerk, N., Armstrong, B. K., Kellie, S., Ashton, L. J., Milne, E., & Fritschi, L. (2013). Parental occupational exposure to engine exhausts and childhood brain tumors. International Journal of Cancer, 132(12), 2975-9. https://doi.org/10.1002/ijc.27972
Peters S, et al. Parental Occupational Exposure to Engine Exhausts and Childhood Brain Tumors. Int J Cancer. 2013 Jun 15;132(12):2975-9. PubMed PMID: 23184618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental occupational exposure to engine exhausts and childhood brain tumors. AU - Peters,Susan, AU - Glass,Deborah C, AU - Reid,Alison, AU - de Klerk,Nicholas, AU - Armstrong,Bruce K, AU - Kellie,Stewart, AU - Ashton,Lesley J, AU - Milne,Elizabeth, AU - Fritschi,Lin, Y1 - 2012/12/19/ PY - 2012/08/30/received PY - 2012/10/29/accepted PY - 2012/11/28/entrez PY - 2012/11/28/pubmed PY - 2013/6/13/medline SP - 2975 EP - 9 JF - International journal of cancer JO - Int J Cancer VL - 132 IS - 12 N2 - Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. Since most CBTs are diagnosed before five years of age, prenatal exposure and early postnatal factors may be involved in their etiology. We investigated the association between CBT and parental occupational exposure to engine exhausts in an Australian population-based case-control study. Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for both maternal and paternal exposure in key time periods. Increased risks were observed for maternal exposure to diesel exhaust any time before the child's birth (OR 2.03, 95% CI 1.09-3.81) and paternal exposure around the time of the child's conception (OR 1.62, 95% CI 1.12-2.34). No clear associations with other engine exhausts were found. Our results suggest that parental occupational exposure to diesel exhaust may increase the risk of CBT. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23184618/Parental_occupational_exposure_to_engine_exhausts_and_childhood_brain_tumors_ L2 - https://doi.org/10.1002/ijc.27972 DB - PRIME DP - Unbound Medicine ER -