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[Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results].
Rev Med Suisse. 2012 Oct 31; 8(360):2052-4, 2056-8.RM

Abstract

Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results When vitamin B12 deficiency is expressed clinically, the diagnostic performance of total cobalamin is identical to that of holotranscobalamin II. In subclinical B12 deficiency, the two aforementioned markers perform less well. Additional analysis of a second, functional marker (methylmalonate or homocysteine) is recommended. Different analytical approaches for 25-hydroxyvitamin D quantification, the marker of vitamin D deficiency, are not yet standardized. Measurement biases of up to +/- 20% compared with the original method used to establish threshold values are still observed.

Authors+Show Affiliations

Boulat O
Service de biomédecine, Laboratoire de chimie clinique, CHUV, 1011 Lausanne. olivier.boulat@chuv.ch
Rey F
No affiliation info available
Mooser V
No affiliation info available

MeSH

BiomarkersHomocysteineHumansMethylmalonic AcidTranscobalaminsVitamin B 12Vitamin B 12 DeficiencyVitamin DVitamin D Deficiency

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

23185926

Citation

Boulat, O, et al. "[Biological Markers for the Status of Vitamins B12 and D: the Importance of some Analytical Aspects in Relation to Clinical Interpretation of Results]." Revue Medicale Suisse, vol. 8, no. 360, 2012, pp. 2052-4, 2056-8.
Boulat O, Rey F, Mooser V. [Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results]. Rev Med Suisse. 2012;8(360):2052-4, 2056-8.
Boulat, O., Rey, F., & Mooser, V. (2012). [Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results]. Revue Medicale Suisse, 8(360), 2052-4, 2056-8.
Boulat O, Rey F, Mooser V. [Biological Markers for the Status of Vitamins B12 and D: the Importance of some Analytical Aspects in Relation to Clinical Interpretation of Results]. Rev Med Suisse. 2012 Oct 31;8(360):2052-4, 2056-8. PubMed PMID: 23185926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results]. AU - Boulat,O, AU - Rey,F, AU - Mooser,V, PY - 2012/11/29/entrez PY - 2012/11/29/pubmed PY - 2013/1/10/medline SP - 2052-4, 2056-8 JF - Revue medicale suisse JO - Rev Med Suisse VL - 8 IS - 360 N2 - Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results When vitamin B12 deficiency is expressed clinically, the diagnostic performance of total cobalamin is identical to that of holotranscobalamin II. In subclinical B12 deficiency, the two aforementioned markers perform less well. Additional analysis of a second, functional marker (methylmalonate or homocysteine) is recommended. Different analytical approaches for 25-hydroxyvitamin D quantification, the marker of vitamin D deficiency, are not yet standardized. Measurement biases of up to +/- 20% compared with the original method used to establish threshold values are still observed. SN - 1660-9379 UR - https://www.unboundmedicine.com/medline/citation/23185926/[Biological_markers_for_the_status_of_vitamins_B12_and_D:_the_importance_of_some_analytical_aspects_in_relation_to_clinical_interpretation_of_results]_ L2 - https://medlineplus.gov/vitamind.html DB - PRIME DP - Unbound Medicine ER -