[Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results].Rev Med Suisse. 2012 Oct 31; 8(360):2052-4, 2056-8.RM
Abstract
Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results When vitamin B12 deficiency is expressed clinically, the diagnostic performance of total cobalamin is identical to that of holotranscobalamin II. In subclinical B12 deficiency, the two aforementioned markers perform less well. Additional analysis of a second, functional marker (methylmalonate or homocysteine) is recommended. Different analytical approaches for 25-hydroxyvitamin D quantification, the marker of vitamin D deficiency, are not yet standardized. Measurement biases of up to +/- 20% compared with the original method used to establish threshold values are still observed.
MeSH
Pub Type(s)
English Abstract
Journal Article
Language
fre
PubMed ID
23185926
Citation
Boulat, O, et al. "[Biological Markers for the Status of Vitamins B12 and D: the Importance of some Analytical Aspects in Relation to Clinical Interpretation of Results]." Revue Medicale Suisse, vol. 8, no. 360, 2012, pp. 2052-4, 2056-8.
Boulat O, Rey F, Mooser V. [Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results]. Rev Med Suisse. 2012;8(360):2052-4, 2056-8.
Boulat, O., Rey, F., & Mooser, V. (2012). [Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results]. Revue Medicale Suisse, 8(360), 2052-4, 2056-8.
Boulat O, Rey F, Mooser V. [Biological Markers for the Status of Vitamins B12 and D: the Importance of some Analytical Aspects in Relation to Clinical Interpretation of Results]. Rev Med Suisse. 2012 Oct 31;8(360):2052-4, 2056-8. PubMed PMID: 23185926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - [Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results].
AU - Boulat,O,
AU - Rey,F,
AU - Mooser,V,
PY - 2012/11/29/entrez
PY - 2012/11/29/pubmed
PY - 2013/1/10/medline
SP - 2052-4, 2056-8
JF - Revue medicale suisse
JO - Rev Med Suisse
VL - 8
IS - 360
N2 - Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results When vitamin B12 deficiency is expressed clinically, the diagnostic performance of total cobalamin is identical to that of holotranscobalamin II. In subclinical B12 deficiency, the two aforementioned markers perform less well. Additional analysis of a second, functional marker (methylmalonate or homocysteine) is recommended. Different analytical approaches for 25-hydroxyvitamin D quantification, the marker of vitamin D deficiency, are not yet standardized. Measurement biases of up to +/- 20% compared with the original method used to establish threshold values are still observed.
SN - 1660-9379
UR - https://www.unboundmedicine.com/medline/citation/23185926/[Biological_markers_for_the_status_of_vitamins_B12_and_D:_the_importance_of_some_analytical_aspects_in_relation_to_clinical_interpretation_of_results]_
L2 - https://medlineplus.gov/vitamind.html
DB - PRIME
DP - Unbound Medicine
ER -