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Role of vitamin D in the onset, progression, and severity of multiple sclerosis.
Endocr Pract 2013 Jan-Feb; 19(1):129-36EP

Abstract

OBJECTIVE

To review and assess the role of vitamin D in the onset, progression, and relapse of multiple sclerosis (MS), based on evidence acquired from the analysis of preclinical, observational, and interventional studies.

METHODS

All English language literature in MEDLINE (January 1969 through April 2012) was searched for observational and interventional studies on the dosage effect of vitamin D on the onset, progression, and relapse rate of MS. The medical subject heading (MeSH) terms used in the search included Vitamin D and Multiple Sclerosis. Additional publications and abstracts were identified from review articles and from the references cited in the previously found articles. In addition to the experimental studies, only those human studies that specified the population size, doses of vitamin D used, and the resulting effect on MS were considered.

RESULTS

Vitamin D deficiency is very common among MS patients. Multiple preclinical studies have shown that vitamin D is a potent regulator of inflammation in MS. Most observational studies support an association between high vitamin D levels and a reduced risk of developing MS. However, conflicting results have been reported by observational studies on the correlation between vitamin D and MS severity and by interventional studies using vitamin D as a therapeutic agent for MS.

CONCLUSION

Vitamin D deficiency in MS patients should be avoided. In addition, the risk of developing MS might be reduced by maintaining optimal vitamin D levels in the healthy population. Larger randomized interventional trials are needed to clarify the therapeutic effect of vitamin D in MS.

Authors+Show Affiliations

Division of Endocrinology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL 32209, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23186958

Citation

Mesliniene, Sandra, et al. "Role of Vitamin D in the Onset, Progression, and Severity of Multiple Sclerosis." Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 19, no. 1, 2013, pp. 129-36.
Mesliniene S, Ramrattan L, Giddings S, et al. Role of vitamin D in the onset, progression, and severity of multiple sclerosis. Endocr Pract. 2013;19(1):129-36.
Mesliniene, S., Ramrattan, L., Giddings, S., & Sheikh-Ali, M. (2013). Role of vitamin D in the onset, progression, and severity of multiple sclerosis. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 19(1), pp. 129-36. doi:10.4158/EP12152.RA.
Mesliniene S, et al. Role of Vitamin D in the Onset, Progression, and Severity of Multiple Sclerosis. Endocr Pract. 2013;19(1):129-36. PubMed PMID: 23186958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of vitamin D in the onset, progression, and severity of multiple sclerosis. AU - Mesliniene,Sandra, AU - Ramrattan,Laurie, AU - Giddings,Stanley, AU - Sheikh-Ali,Mae, PY - 2012/11/29/entrez PY - 2012/11/29/pubmed PY - 2013/8/16/medline SP - 129 EP - 36 JF - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JO - Endocr Pract VL - 19 IS - 1 N2 - OBJECTIVE: To review and assess the role of vitamin D in the onset, progression, and relapse of multiple sclerosis (MS), based on evidence acquired from the analysis of preclinical, observational, and interventional studies. METHODS: All English language literature in MEDLINE (January 1969 through April 2012) was searched for observational and interventional studies on the dosage effect of vitamin D on the onset, progression, and relapse rate of MS. The medical subject heading (MeSH) terms used in the search included Vitamin D and Multiple Sclerosis. Additional publications and abstracts were identified from review articles and from the references cited in the previously found articles. In addition to the experimental studies, only those human studies that specified the population size, doses of vitamin D used, and the resulting effect on MS were considered. RESULTS: Vitamin D deficiency is very common among MS patients. Multiple preclinical studies have shown that vitamin D is a potent regulator of inflammation in MS. Most observational studies support an association between high vitamin D levels and a reduced risk of developing MS. However, conflicting results have been reported by observational studies on the correlation between vitamin D and MS severity and by interventional studies using vitamin D as a therapeutic agent for MS. CONCLUSION: Vitamin D deficiency in MS patients should be avoided. In addition, the risk of developing MS might be reduced by maintaining optimal vitamin D levels in the healthy population. Larger randomized interventional trials are needed to clarify the therapeutic effect of vitamin D in MS. SN - 1934-2403 UR - https://www.unboundmedicine.com/medline/citation/23186958/Role_of_vitamin_D_in_the_onset_progression_and_severity_of_multiple_sclerosis_ L2 - http://journals.aace.com/doi/10.4158/EP12152.RA?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -