Tags

Type your tag names separated by a space and hit enter

Improved clinical status, quality of life, and walking capacity in Parkinson's disease after body weight-supported high-intensity locomotor training.
Arch Phys Med Rehabil. 2013 Apr; 94(4):687-92.AP

Abstract

OBJECTIVE

To evaluate the effect of body weight-supported progressive high-intensity locomotor training in Parkinson's disease (PD) on (1) clinical status; (2) quality of life; and (3) gait capacity.

DESIGN

Open-label, fixed sequence crossover study.

SETTING

University motor control laboratory.

PARTICIPANTS

Patients (N=13) with idiopathic PD (Hoehn and Yahr stage 2 or 3) and stable medication use.

INTERVENTIONS

Patients completed an 8-week (3 × 1h/wk) training program on a lower-body positive-pressure treadmill. Body weight support was used to facilitate increased intensity and motor challenges during treadmill training. The training program contained combinations of (1) running and walking intervals, (2) the use of sudden changes (eg, in body weight support and speed), (3) different types of locomotion (eg, chassé, skipping, and jumps), and (4) sprints at 50 percent body weight.

MAIN OUTCOME MEASURES

The Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and the six-minute walk test were conducted 8 weeks before and pre- and posttraining.

RESULTS

At the end of training, statistically significant improvements were found in all outcome measures compared with the control period. Total MDS-UPDRS score changed from (mean ± 1SD) 58±18 to 47±18, MDS-UPDRS motor part score changed from 35±10 to 29±12, PDQ-39 summary index score changed from 22±13 to 13±12, and the six-minute walking distance changed from 576±93 to 637±90m.

CONCLUSIONS

Body weight-supported progressive high-intensity locomotor training is feasible and well tolerated by patients with PD. The training improved clinical status, quality of life, and gait capacity significantly.

Authors+Show Affiliations

Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark. mrose@ifi.ku.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

23187043

Citation

Rose, Martin H., et al. "Improved Clinical Status, Quality of Life, and Walking Capacity in Parkinson's Disease After Body Weight-supported High-intensity Locomotor Training." Archives of Physical Medicine and Rehabilitation, vol. 94, no. 4, 2013, pp. 687-92.
Rose MH, Løkkegaard A, Sonne-Holm S, et al. Improved clinical status, quality of life, and walking capacity in Parkinson's disease after body weight-supported high-intensity locomotor training. Arch Phys Med Rehabil. 2013;94(4):687-92.
Rose, M. H., Løkkegaard, A., Sonne-Holm, S., & Jensen, B. R. (2013). Improved clinical status, quality of life, and walking capacity in Parkinson's disease after body weight-supported high-intensity locomotor training. Archives of Physical Medicine and Rehabilitation, 94(4), 687-92. https://doi.org/10.1016/j.apmr.2012.11.025
Rose MH, et al. Improved Clinical Status, Quality of Life, and Walking Capacity in Parkinson's Disease After Body Weight-supported High-intensity Locomotor Training. Arch Phys Med Rehabil. 2013;94(4):687-92. PubMed PMID: 23187043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved clinical status, quality of life, and walking capacity in Parkinson's disease after body weight-supported high-intensity locomotor training. AU - Rose,Martin H, AU - Løkkegaard,Annemette, AU - Sonne-Holm,Stig, AU - Jensen,Bente R, Y1 - 2012/11/24/ PY - 2012/07/03/received PY - 2012/11/04/revised PY - 2012/11/15/accepted PY - 2012/11/29/entrez PY - 2012/11/29/pubmed PY - 2013/5/17/medline SP - 687 EP - 92 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 94 IS - 4 N2 - OBJECTIVE: To evaluate the effect of body weight-supported progressive high-intensity locomotor training in Parkinson's disease (PD) on (1) clinical status; (2) quality of life; and (3) gait capacity. DESIGN: Open-label, fixed sequence crossover study. SETTING: University motor control laboratory. PARTICIPANTS: Patients (N=13) with idiopathic PD (Hoehn and Yahr stage 2 or 3) and stable medication use. INTERVENTIONS: Patients completed an 8-week (3 × 1h/wk) training program on a lower-body positive-pressure treadmill. Body weight support was used to facilitate increased intensity and motor challenges during treadmill training. The training program contained combinations of (1) running and walking intervals, (2) the use of sudden changes (eg, in body weight support and speed), (3) different types of locomotion (eg, chassé, skipping, and jumps), and (4) sprints at 50 percent body weight. MAIN OUTCOME MEASURES: The Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Parkinson's Disease Questionnaire-39 items (PDQ-39), and the six-minute walk test were conducted 8 weeks before and pre- and posttraining. RESULTS: At the end of training, statistically significant improvements were found in all outcome measures compared with the control period. Total MDS-UPDRS score changed from (mean ± 1SD) 58±18 to 47±18, MDS-UPDRS motor part score changed from 35±10 to 29±12, PDQ-39 summary index score changed from 22±13 to 13±12, and the six-minute walking distance changed from 576±93 to 637±90m. CONCLUSIONS: Body weight-supported progressive high-intensity locomotor training is feasible and well tolerated by patients with PD. The training improved clinical status, quality of life, and gait capacity significantly. SN - 1532-821X UR - https://www.unboundmedicine.com/medline/citation/23187043/Improved_clinical_status_quality_of_life_and_walking_capacity_in_Parkinson's_disease_after_body_weight_supported_high_intensity_locomotor_training_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(12)01186-0 DB - PRIME DP - Unbound Medicine ER -