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CoQ10 and L-carnitine for statin myalgia?
Expert Rev Cardiovasc Ther. 2012 Oct; 10(10):1329-33.ER

Abstract

Statins are a standard of care in many clinical settings such as acute myocardial infarction and for patients having or at risk of cardiovascular (CV) disease. This is based on a plethora of data showing reductions in CV events and mortality. The CV benefit of statins can be partly explained by their ability to inhibit of HMG-CoA reductase, which subsequently lowers cholesterol and decreases the formation of mevalonate. However, the inhibition of the mevalonate pathway decreases the formation of coenzyme Q10 (CoQ10) within the body. It has been a long-standing theory that statin-associated muscle pain (myalgia) is caused, or at least partly contributed by, a reduction in CoQ10 levels in muscle mitochondria. One of the main side effects of statins is myalgia, which causes the patient to either stop their statin or significantly reduce the dose of their statin. The question of whether CoQ10 can help treat statin myopathy is a common one encountered by clinicians in current day practice.

Authors+Show Affiliations

Wegmans Pharmacy, 500 South Meadow Street Ithaca, Ithaca, NY 14850, USA. jjdinicol@gmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23190071

Citation

DiNicolantonio, James J.. "CoQ10 and L-carnitine for Statin Myalgia?" Expert Review of Cardiovascular Therapy, vol. 10, no. 10, 2012, pp. 1329-33.
DiNicolantonio JJ. CoQ10 and L-carnitine for statin myalgia? Expert Rev Cardiovasc Ther. 2012;10(10):1329-33.
DiNicolantonio, J. J. (2012). CoQ10 and L-carnitine for statin myalgia? Expert Review of Cardiovascular Therapy, 10(10), 1329-33. https://doi.org/10.1586/erc.12.92
DiNicolantonio JJ. CoQ10 and L-carnitine for Statin Myalgia. Expert Rev Cardiovasc Ther. 2012;10(10):1329-33. PubMed PMID: 23190071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CoQ10 and L-carnitine for statin myalgia? A1 - DiNicolantonio,James J, PY - 2012/11/30/entrez PY - 2012/11/30/pubmed PY - 2013/5/4/medline SP - 1329 EP - 33 JF - Expert review of cardiovascular therapy JO - Expert Rev Cardiovasc Ther VL - 10 IS - 10 N2 - Statins are a standard of care in many clinical settings such as acute myocardial infarction and for patients having or at risk of cardiovascular (CV) disease. This is based on a plethora of data showing reductions in CV events and mortality. The CV benefit of statins can be partly explained by their ability to inhibit of HMG-CoA reductase, which subsequently lowers cholesterol and decreases the formation of mevalonate. However, the inhibition of the mevalonate pathway decreases the formation of coenzyme Q10 (CoQ10) within the body. It has been a long-standing theory that statin-associated muscle pain (myalgia) is caused, or at least partly contributed by, a reduction in CoQ10 levels in muscle mitochondria. One of the main side effects of statins is myalgia, which causes the patient to either stop their statin or significantly reduce the dose of their statin. The question of whether CoQ10 can help treat statin myopathy is a common one encountered by clinicians in current day practice. SN - 1744-8344 UR - https://www.unboundmedicine.com/medline/citation/23190071/CoQ10_and_L_carnitine_for_statin_myalgia L2 - http://www.tandfonline.com/doi/full/10.1586/erc.12.92 DB - PRIME DP - Unbound Medicine ER -