Tags

Type your tag names separated by a space and hit enter

Dietary glycemic index, glycemic load, and digestible carbohydrate intake are not associated with risk of type 2 diabetes in eight European countries.
J Nutr 2013; 143(1):93-9JN

Abstract

The association of glycemic index (GI) and glycemic load (GL) with the risk of type 2 diabetes remains unclear. We investigated associations of dietary GI, GL, and digestible carbohydrate with incident type 2 diabetes. We performed a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition Study, including a random subcohort (n = 16,835) and incident type 2 diabetes cases (n = 12,403). The median follow-up time was 12 y. Baseline dietary intakes were assessed using country-specific dietary questionnaires. Country-specific HR were calculated and pooled using random effects meta-analysis. Dietary GI, GL, and digestible carbohydrate in the subcohort were (mean ± SD) 56 ± 4, 127 ± 23, and 226 ± 36 g/d, respectively. After adjustment for confounders, GI and GL were not associated with incident diabetes [HR highest vs. lowest quartile (HR(Q4)) for GI: 1.05 (95% CI = 0.96, 1.16); HR(Q4) for GL: 1.07 (95% CI = 0.95, 1.20)]. Digestible carbohydrate intake was not associated with incident diabetes [HR(Q4): 0.98 (95% CI = 0.86, 1.10)]. In additional analyses, we found that discrepancies in the GI value assignment to foods possibly explain differences in GI associations with diabetes within the same study population. In conclusion, an expansion of the GI tables and systematic GI value assignment to foods may be needed to improve the validity of GI values derived in such studies, after which GI associations may need reevaluation. Our study shows that digestible carbohydrate intake is not associated with diabetes risk and suggests that diabetes risk with high-GI and -GL diets may be more modest than initial studies suggested.

Authors+Show Affiliations

University Medical Center, Utrecht, The Netherlands. i.sluijs-2@umcutrecht.nl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23190759

Citation

Sluijs, Ivonne, et al. "Dietary Glycemic Index, Glycemic Load, and Digestible Carbohydrate Intake Are Not Associated With Risk of Type 2 Diabetes in Eight European Countries." The Journal of Nutrition, vol. 143, no. 1, 2013, pp. 93-9.
Sluijs I, Beulens JW, van der Schouw YT, et al. Dietary glycemic index, glycemic load, and digestible carbohydrate intake are not associated with risk of type 2 diabetes in eight European countries. J Nutr. 2013;143(1):93-9.
Sluijs, I., Beulens, J. W., van der Schouw, Y. T., van der A, D. L., Buckland, G., Kuijsten, A., ... Wareham, N. J. (2013). Dietary glycemic index, glycemic load, and digestible carbohydrate intake are not associated with risk of type 2 diabetes in eight European countries. The Journal of Nutrition, 143(1), pp. 93-9. doi:10.3945/jn.112.165605.
Sluijs I, et al. Dietary Glycemic Index, Glycemic Load, and Digestible Carbohydrate Intake Are Not Associated With Risk of Type 2 Diabetes in Eight European Countries. J Nutr. 2013;143(1):93-9. PubMed PMID: 23190759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary glycemic index, glycemic load, and digestible carbohydrate intake are not associated with risk of type 2 diabetes in eight European countries. AU - Sluijs,Ivonne, AU - Beulens,Joline W J, AU - van der Schouw,Yvonne T, AU - van der A,Daphne L, AU - Buckland,Genevieve, AU - Kuijsten,Anneleen, AU - Schulze,Matthias B, AU - Amiano,Pilar, AU - Ardanaz,Eva, AU - Balkau,Beverley, AU - Boeing,Heiner, AU - Gavrila,Diana, AU - Grote,Verena A, AU - Key,Timothy J, AU - Li,Kuanrong, AU - Nilsson,Peter, AU - Overvad,Kim, AU - Palli,Domenico, AU - Panico,Salvatore, AU - Quirós,J R, AU - Rolandsson,Olov, AU - Roswall,Nina, AU - Sacerdote,Carlotta, AU - Sánchez,María-José, AU - Sieri,Sabina, AU - Slimani,Nadia, AU - Spijkerman,Annemieke M W, AU - Tjønneland,Anne, AU - Tumino,Rosario, AU - Sharp,Stephen J, AU - Langenberg,Claudia, AU - Feskens,Edith J M, AU - Forouhi,Nita G, AU - Riboli,Elio, AU - Wareham,Nicholas J, AU - ,, Y1 - 2012/11/28/ PY - 2012/11/30/entrez PY - 2012/11/30/pubmed PY - 2013/2/26/medline SP - 93 EP - 9 JF - The Journal of nutrition JO - J. Nutr. VL - 143 IS - 1 N2 - The association of glycemic index (GI) and glycemic load (GL) with the risk of type 2 diabetes remains unclear. We investigated associations of dietary GI, GL, and digestible carbohydrate with incident type 2 diabetes. We performed a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition Study, including a random subcohort (n = 16,835) and incident type 2 diabetes cases (n = 12,403). The median follow-up time was 12 y. Baseline dietary intakes were assessed using country-specific dietary questionnaires. Country-specific HR were calculated and pooled using random effects meta-analysis. Dietary GI, GL, and digestible carbohydrate in the subcohort were (mean ± SD) 56 ± 4, 127 ± 23, and 226 ± 36 g/d, respectively. After adjustment for confounders, GI and GL were not associated with incident diabetes [HR highest vs. lowest quartile (HR(Q4)) for GI: 1.05 (95% CI = 0.96, 1.16); HR(Q4) for GL: 1.07 (95% CI = 0.95, 1.20)]. Digestible carbohydrate intake was not associated with incident diabetes [HR(Q4): 0.98 (95% CI = 0.86, 1.10)]. In additional analyses, we found that discrepancies in the GI value assignment to foods possibly explain differences in GI associations with diabetes within the same study population. In conclusion, an expansion of the GI tables and systematic GI value assignment to foods may be needed to improve the validity of GI values derived in such studies, after which GI associations may need reevaluation. Our study shows that digestible carbohydrate intake is not associated with diabetes risk and suggests that diabetes risk with high-GI and -GL diets may be more modest than initial studies suggested. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23190759/Dietary_glycemic_index_glycemic_load_and_digestible_carbohydrate_intake_are_not_associated_with_risk_of_type_2_diabetes_in_eight_European_countries_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.165605 DB - PRIME DP - Unbound Medicine ER -