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Relapses in paucibacillary leprosy after MDT--a clinical study.
Int J Lepr Other Mycobact Dis. 1990 Mar; 58(1):19-24.IJ

Abstract

A study was undertaken in a field-based project to assess the incidence and clinical profile of relapses occurring in paucibacillary leprosy patients after adequate doses of multidrug therapy (MDT). Of the 1509 paucibacillary patients who had received not less than 6 doses of MDT (WHO regimen), 85 relapsed; a relapse rate of 5.63% (17.5/1000 person years at risk). These relapses included 12 cases with features of reversal reaction. Seventy-nine percent of the patients relapsed with skin lesions. The relapse rate was higher in borderline cases and in those with more lesions, and it was lower in those who had received dapsone for at least 6 months after cessation of MDT. Seventy-four percent of the relapses were detected between 7 and 24 months of follow up. We feel that uniform clinical criteria should be formulated for the diagnosis of relapse. Individualization of therapy, rather than adhering to a fixed duration of MDT, would be likely to achieve satisfactory cure rates and fewer relapses.

Authors+Show Affiliations

L.T.M.M. College, Bombay, Maharashtra, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2319185

Citation

Grugni, A, et al. "Relapses in Paucibacillary Leprosy After MDT--a Clinical Study." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 58, no. 1, 1990, pp. 19-24.
Grugni A, Nadkarni NJ, Kini MS, et al. Relapses in paucibacillary leprosy after MDT--a clinical study. Int J Lepr Other Mycobact Dis. 1990;58(1):19-24.
Grugni, A., Nadkarni, N. J., Kini, M. S., & Mehta, V. R. (1990). Relapses in paucibacillary leprosy after MDT--a clinical study. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 58(1), 19-24.
Grugni A, et al. Relapses in Paucibacillary Leprosy After MDT--a Clinical Study. Int J Lepr Other Mycobact Dis. 1990;58(1):19-24. PubMed PMID: 2319185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relapses in paucibacillary leprosy after MDT--a clinical study. AU - Grugni,A, AU - Nadkarni,N J, AU - Kini,M S, AU - Mehta,V R, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 19 EP - 24 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 58 IS - 1 N2 - A study was undertaken in a field-based project to assess the incidence and clinical profile of relapses occurring in paucibacillary leprosy patients after adequate doses of multidrug therapy (MDT). Of the 1509 paucibacillary patients who had received not less than 6 doses of MDT (WHO regimen), 85 relapsed; a relapse rate of 5.63% (17.5/1000 person years at risk). These relapses included 12 cases with features of reversal reaction. Seventy-nine percent of the patients relapsed with skin lesions. The relapse rate was higher in borderline cases and in those with more lesions, and it was lower in those who had received dapsone for at least 6 months after cessation of MDT. Seventy-four percent of the relapses were detected between 7 and 24 months of follow up. We feel that uniform clinical criteria should be formulated for the diagnosis of relapse. Individualization of therapy, rather than adhering to a fixed duration of MDT, would be likely to achieve satisfactory cure rates and fewer relapses. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2319185/Relapses_in_paucibacillary_leprosy_after_MDT__a_clinical_study_ DB - PRIME DP - Unbound Medicine ER -