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Nodal status is not a prognostic factor in patients with HPV-positive oral/oropharyngeal tumors.
J Surg Oncol. 2013 May; 107(6):625-33.JS

Abstract

OBJECTIVES

The primary aim is to compare the prognostic parameters in patients with HPV-positive and HPV-negative tumors. The secondary aim is to compare the patterns of treatment failure between these groups.

METHODS

Analysis of prognostic factors in a group of 170 patients.

RESULTS

High-risk HPV DNA was detected in 98 cases, 72 tumors were HPV negative. Both the overall and disease-specific survival rates were better in HPV-positive patients. In patients with HPV-negative tumors, the prognostic factors in univariate analysis were pT and pN classification, tumor stage, number of positive nodes, and extracapsular spread. Stage, pT, higher pN, and number of nodes maintained statistical significance after adjustment. None of the studied prognostic factors was significant in the group of patients with HPV-positive tumors. There was a significant difference in the local--regional recurrence rates--37% in HPV-negative cases and 18% in HPV-positive cases.

CONCLUSION

The characteristics of the extent of the disease in general and of regional lymph node metastasis in particular are probably much less important in the prediction of the outcome of HPV-positive than of HPV-negative tumors. Improved survival of patients with HPV-positive tumors is due mostly to the difference in the local-regional failure rates.

Authors+Show Affiliations

First Faculty of Medicine, Department of Otolaryngology, Head and Neck Surgery, Charles University in Prague, Prague, Czech Republic. jan.klozar@lfmotol.cuni.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23192334

Citation

Klozar, Jan, et al. "Nodal Status Is Not a Prognostic Factor in Patients With HPV-positive Oral/oropharyngeal Tumors." Journal of Surgical Oncology, vol. 107, no. 6, 2013, pp. 625-33.
Klozar J, Koslabova E, Kratochvil V, et al. Nodal status is not a prognostic factor in patients with HPV-positive oral/oropharyngeal tumors. J Surg Oncol. 2013;107(6):625-33.
Klozar, J., Koslabova, E., Kratochvil, V., Salakova, M., & Tachezy, R. (2013). Nodal status is not a prognostic factor in patients with HPV-positive oral/oropharyngeal tumors. Journal of Surgical Oncology, 107(6), 625-33. https://doi.org/10.1002/jso.23292
Klozar J, et al. Nodal Status Is Not a Prognostic Factor in Patients With HPV-positive Oral/oropharyngeal Tumors. J Surg Oncol. 2013;107(6):625-33. PubMed PMID: 23192334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nodal status is not a prognostic factor in patients with HPV-positive oral/oropharyngeal tumors. AU - Klozar,Jan, AU - Koslabova,Eva, AU - Kratochvil,Vit, AU - Salakova,Martina, AU - Tachezy,Ruth, Y1 - 2012/11/28/ PY - 2012/06/06/received PY - 2012/10/22/accepted PY - 2012/11/30/entrez PY - 2012/11/30/pubmed PY - 2013/6/12/medline SP - 625 EP - 33 JF - Journal of surgical oncology JO - J Surg Oncol VL - 107 IS - 6 N2 - OBJECTIVES: The primary aim is to compare the prognostic parameters in patients with HPV-positive and HPV-negative tumors. The secondary aim is to compare the patterns of treatment failure between these groups. METHODS: Analysis of prognostic factors in a group of 170 patients. RESULTS: High-risk HPV DNA was detected in 98 cases, 72 tumors were HPV negative. Both the overall and disease-specific survival rates were better in HPV-positive patients. In patients with HPV-negative tumors, the prognostic factors in univariate analysis were pT and pN classification, tumor stage, number of positive nodes, and extracapsular spread. Stage, pT, higher pN, and number of nodes maintained statistical significance after adjustment. None of the studied prognostic factors was significant in the group of patients with HPV-positive tumors. There was a significant difference in the local--regional recurrence rates--37% in HPV-negative cases and 18% in HPV-positive cases. CONCLUSION: The characteristics of the extent of the disease in general and of regional lymph node metastasis in particular are probably much less important in the prediction of the outcome of HPV-positive than of HPV-negative tumors. Improved survival of patients with HPV-positive tumors is due mostly to the difference in the local-regional failure rates. SN - 1096-9098 UR - https://www.unboundmedicine.com/medline/citation/23192334/Nodal_status_is_not_a_prognostic_factor_in_patients_with_HPV_positive_oral/oropharyngeal_tumors_ L2 - https://doi.org/10.1002/jso.23292 DB - PRIME DP - Unbound Medicine ER -