Tags

Type your tag names separated by a space and hit enter

Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study.
Arthritis Rheum 2012; 64(12):3947-54AR

Abstract

OBJECTIVE

Sarcopenic obesity is a body composition category in which obesity is accompanied by low skeletal muscle mass, offsetting the increase in body weight caused by increased adipose tissue. The purpose of this study was to analyze the association between knee osteoarthritis (OA) and 4 different categories of body composition: normal, sarcopenic nonobesity, nonsarcopenic obesity, and sarcopenic obesity.

METHODS

This was a cross-sectional study using the data from 2,893 participants in the Fifth Korean National Health and Nutrition Examination Survey. Radiographic knee OA was defined as a Kellgren/Lawrence grade of ≥2. Appendicular skeletal muscle mass (ASM) and whole-body fat mass were measured using dual x-ray absorptiometry. Sarcopenia was defined as a skeletal muscle mass index (ASM/body weight [%]) below -2SD of the value in sex-matched young reference groups. Nonsarcopenic obesity was defined as a body mass index (BMI) ≥27.5 kg/m(2) .

RESULTS

The prevalence of each body composition category was as follows: 83.5% normal, 4.3% sarcopenic nonobesity, 9.2% nonsarcopenic obesity, and 3.0% sarcopenic obesity. Compared with nonsarcopenic obesity participants, participants with sarcopenic obesity were significantly older, had lower ASM, higher whole-body fat mass, and higher waist circumference. However, there was no significant difference in body weight or BMI. In multivariate analysis, sarcopenic obesity was more closely associated with radiographic knee OA (OR 3.51 [95% confidence interval (95% CI) 2.15-5.75]) than was nonsarcopenic obesity (OR 2.38 [95% CI 1.80-3.15]). Sarcopenic nonobesity showed no significant association with knee OA.

CONCLUSION

Sarcopenic obesity was more closely associated with knee OA than was nonsarcopenic obesity, although both groups had equivalent body weight. This finding supports the importance of the systemic metabolic effect of obesity in knee OA.

Authors+Show Affiliations

Haeundae Paik Hospital and Inje University College of Medicine, Busan, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23192792

Citation

Lee, Sunggun, et al. "Sarcopenic Obesity Is More Closely Associated With Knee Osteoarthritis Than Is Nonsarcopenic Obesity: a Cross-sectional Study." Arthritis and Rheumatism, vol. 64, no. 12, 2012, pp. 3947-54.
Lee S, Kim TN, Kim SH. Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study. Arthritis Rheum. 2012;64(12):3947-54.
Lee, S., Kim, T. N., & Kim, S. H. (2012). Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study. Arthritis and Rheumatism, 64(12), pp. 3947-54. doi:10.1002/art.37696.
Lee S, Kim TN, Kim SH. Sarcopenic Obesity Is More Closely Associated With Knee Osteoarthritis Than Is Nonsarcopenic Obesity: a Cross-sectional Study. Arthritis Rheum. 2012;64(12):3947-54. PubMed PMID: 23192792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study. AU - Lee,Sunggun, AU - Kim,Tae-Nyun, AU - Kim,Seong-Ho, PY - 2012/03/28/received PY - 2012/08/30/accepted PY - 2012/11/30/entrez PY - 2012/11/30/pubmed PY - 2013/4/3/medline SP - 3947 EP - 54 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 64 IS - 12 N2 - OBJECTIVE: Sarcopenic obesity is a body composition category in which obesity is accompanied by low skeletal muscle mass, offsetting the increase in body weight caused by increased adipose tissue. The purpose of this study was to analyze the association between knee osteoarthritis (OA) and 4 different categories of body composition: normal, sarcopenic nonobesity, nonsarcopenic obesity, and sarcopenic obesity. METHODS: This was a cross-sectional study using the data from 2,893 participants in the Fifth Korean National Health and Nutrition Examination Survey. Radiographic knee OA was defined as a Kellgren/Lawrence grade of ≥2. Appendicular skeletal muscle mass (ASM) and whole-body fat mass were measured using dual x-ray absorptiometry. Sarcopenia was defined as a skeletal muscle mass index (ASM/body weight [%]) below -2SD of the value in sex-matched young reference groups. Nonsarcopenic obesity was defined as a body mass index (BMI) ≥27.5 kg/m(2) . RESULTS: The prevalence of each body composition category was as follows: 83.5% normal, 4.3% sarcopenic nonobesity, 9.2% nonsarcopenic obesity, and 3.0% sarcopenic obesity. Compared with nonsarcopenic obesity participants, participants with sarcopenic obesity were significantly older, had lower ASM, higher whole-body fat mass, and higher waist circumference. However, there was no significant difference in body weight or BMI. In multivariate analysis, sarcopenic obesity was more closely associated with radiographic knee OA (OR 3.51 [95% confidence interval (95% CI) 2.15-5.75]) than was nonsarcopenic obesity (OR 2.38 [95% CI 1.80-3.15]). Sarcopenic nonobesity showed no significant association with knee OA. CONCLUSION: Sarcopenic obesity was more closely associated with knee OA than was nonsarcopenic obesity, although both groups had equivalent body weight. This finding supports the importance of the systemic metabolic effect of obesity in knee OA. SN - 1529-0131 UR - https://www.unboundmedicine.com/medline/citation/23192792/Sarcopenic_obesity_is_more_closely_associated_with_knee_osteoarthritis_than_is_nonsarcopenic_obesity:_a_cross_sectional_study_ L2 - https://doi.org/10.1002/art.37696 DB - PRIME DP - Unbound Medicine ER -