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Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women.
Gynecol Endocrinol. 2013 Mar; 29(3):209-12.GE

Abstract

OBJECTIVE

To assess the safety of a nutraceutical compound containing soy isoflavones and Lactobacillus sporogenes on endometrium, breast and liver function.

SETTING

Outpatient Menopausal Clinic.

STUDY DESIGN

130 healthy postmenopausal women suffering from menopausal symptoms were randomized to receive soy isoflavones 60 mg and Lactobacillus sporogenes 1 billion spores (group E: 65 women) or calcium and vitamin D₃ (group C: 65 women). Safety of the treatment was assessed at baseline and after 1 year taking into account endometrial thickness, mammographic density, serum levels of transaminases, γ-GT and bilirubin. Efficacy of the treatment was evaluated rating the score of menopausal symptoms at baseline and every 3 months. The statistical analysis was carried out with χ², Fisher exact's test and ANOVA.

RESULTS

After 12 months of treatment mammographic density, endometrial thickness and hepatic function did not show significant differences between groups, while menopausal symptoms were progressively and significantly reduced in severity and frequency during treatment with soy isoflavones plus Lactobacillus sporogenes versus calcium plus vitamin D₃.

CONCLUSION

A 12 months treatment with a nutraceutical compound based on isoflavones and Lactobacillus sporogenes at the recommended doses is safe for endometrium, mammary glands and liver function in postmenopausal women.

Authors+Show Affiliations

Department of Obstetrics, Gynaecology and Reproductive Sciences - Second University of Naples - Largo Madonna delle Grazie 1, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23194023

Citation

Colacurci, Nicola, et al. "Endometrial, Breast and Liver Safety of Soy Isoflavones Plus Lactobacillus Sporogenes in Post-menopausal Women." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 29, no. 3, 2013, pp. 209-12.
Colacurci N, De Franciscis P, Atlante M, et al. Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women. Gynecol Endocrinol. 2013;29(3):209-12.
Colacurci, N., De Franciscis, P., Atlante, M., Mancino, P., Monti, M., Volpini, G., & Benvenuti, C. (2013). Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 29(3), 209-12. https://doi.org/10.3109/09513590.2012.738724
Colacurci N, et al. Endometrial, Breast and Liver Safety of Soy Isoflavones Plus Lactobacillus Sporogenes in Post-menopausal Women. Gynecol Endocrinol. 2013;29(3):209-12. PubMed PMID: 23194023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women. AU - Colacurci,Nicola, AU - De Franciscis,Pasquale, AU - Atlante,Marco, AU - Mancino,Pasquale, AU - Monti,Marco, AU - Volpini,Giuseppe, AU - Benvenuti,Claudio, Y1 - 2012/11/30/ PY - 2012/12/1/entrez PY - 2012/12/1/pubmed PY - 2013/8/21/medline SP - 209 EP - 12 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 29 IS - 3 N2 - OBJECTIVE: To assess the safety of a nutraceutical compound containing soy isoflavones and Lactobacillus sporogenes on endometrium, breast and liver function. SETTING: Outpatient Menopausal Clinic. STUDY DESIGN: 130 healthy postmenopausal women suffering from menopausal symptoms were randomized to receive soy isoflavones 60 mg and Lactobacillus sporogenes 1 billion spores (group E: 65 women) or calcium and vitamin D₃ (group C: 65 women). Safety of the treatment was assessed at baseline and after 1 year taking into account endometrial thickness, mammographic density, serum levels of transaminases, γ-GT and bilirubin. Efficacy of the treatment was evaluated rating the score of menopausal symptoms at baseline and every 3 months. The statistical analysis was carried out with χ², Fisher exact's test and ANOVA. RESULTS: After 12 months of treatment mammographic density, endometrial thickness and hepatic function did not show significant differences between groups, while menopausal symptoms were progressively and significantly reduced in severity and frequency during treatment with soy isoflavones plus Lactobacillus sporogenes versus calcium plus vitamin D₃. CONCLUSION: A 12 months treatment with a nutraceutical compound based on isoflavones and Lactobacillus sporogenes at the recommended doses is safe for endometrium, mammary glands and liver function in postmenopausal women. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/23194023/Endometrial_breast_and_liver_safety_of_soy_isoflavones_plus_Lactobacillus_sporogenes_in_post_menopausal_women_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2012.738724 DB - PRIME DP - Unbound Medicine ER -