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Comparison of erythrocyte membrane fatty acid contents in renal transplant recipients and dialysis patients.
Transplant Proc. 2012 Dec; 44(10):2932-5.TP

Abstract

BACKGROUND

Alterations of erythrocyte membrane fatty acid (FA) composition play important roles in cellular function because they change the membrane microenvironment, including transmembrane receptors. The erythrocyte membrane oleic acid content is higher among patients with acute coronary syndrome and also in dialysis patients. However, available data are limited concerning erythrocyte membrane FA content in kidney transplant recipients (KTP). We sought to test the hypothesis that erythrocyte membrane FA content among KTP were different from those in dialysis patients.

METHODS

In this cross-sectional study, we recruited 35 hemodialysis, 33 peritoneal dialysis 49 KTP, and 33 normal control subjects (CTL). Their erythrocyte membrane FA content were measured by gas chromatography.

RESULTS

The mean ages of the enrolled dialysis patients, KTP, and CTL were 56.4 ± 10.1, 48.9 ± 10.4, and 49.5 ± 8.3 years, respectively. Mean kidney transplant duration was 89.8 ± 64.8 months and mean dialysis duration, 49.0 ± 32.6 months. The intakes of vegetable lipid and vegetable protein including total calories were significantly increased among KTP versus dialysis patients. Total cholesterol (P < .001) and high density lipoprotein cholesterol (HDL; P < .001) levels were significantly higher and C-reactive protein was significantly lower among KTP compared with dialysis patients. The erythrocyte membrane content of palmitoleic acid (P < .001) was significantly higher but oleic acid (P < .001) significantly lower in KTP compared with dialysis patients. The erythrocyte membrane contents of arachidonic acid and docosahexaenoic acid were significantly higher, and linoleic acid and the omega-6 FA to omega-3 FA ratio (P < .001) significantly lower in KTP compared with dialysis patients. The erythrocyte membrane content of oleic acid was independently associated with monounsaturated fatty acid (beta = 0.771, P < .001), eicosapentaeonic acid (beta = -0.244, P = .010), and HDL (beta = -0.139, P = .049) in KTP.

CONCLUSIONS

FA contents of erythrocyte membranes were significantly different in KTP compared with dialysis patients. These differences may have been associated with improved dietary intake and immunosuppression after kidney transplantation.

Authors+Show Affiliations

Department of Internal Medicine, Bong-Seng Hospital, Busan, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23195000

Citation

Oh, J S., et al. "Comparison of Erythrocyte Membrane Fatty Acid Contents in Renal Transplant Recipients and Dialysis Patients." Transplantation Proceedings, vol. 44, no. 10, 2012, pp. 2932-5.
Oh JS, Kim SM, Sin YH, et al. Comparison of erythrocyte membrane fatty acid contents in renal transplant recipients and dialysis patients. Transplant Proc. 2012;44(10):2932-5.
Oh, J. S., Kim, S. M., Sin, Y. H., Kim, J. K., Park, Y., Bae, H. R., Son, Y. K., Nam, H. K., Kang, H. J., & An, W. S. (2012). Comparison of erythrocyte membrane fatty acid contents in renal transplant recipients and dialysis patients. Transplantation Proceedings, 44(10), 2932-5. https://doi.org/10.1016/j.transproceed.2012.04.041
Oh JS, et al. Comparison of Erythrocyte Membrane Fatty Acid Contents in Renal Transplant Recipients and Dialysis Patients. Transplant Proc. 2012;44(10):2932-5. PubMed PMID: 23195000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of erythrocyte membrane fatty acid contents in renal transplant recipients and dialysis patients. AU - Oh,J S, AU - Kim,S M, AU - Sin,Y H, AU - Kim,J K, AU - Park,Y, AU - Bae,H R, AU - Son,Y K, AU - Nam,H K, AU - Kang,H J, AU - An,W S, Y1 - 2012/11/06/ PY - 2012/01/29/received PY - 2012/04/17/accepted PY - 2012/12/1/entrez PY - 2012/12/1/pubmed PY - 2013/5/15/medline SP - 2932 EP - 5 JF - Transplantation proceedings JO - Transplant Proc VL - 44 IS - 10 N2 - BACKGROUND: Alterations of erythrocyte membrane fatty acid (FA) composition play important roles in cellular function because they change the membrane microenvironment, including transmembrane receptors. The erythrocyte membrane oleic acid content is higher among patients with acute coronary syndrome and also in dialysis patients. However, available data are limited concerning erythrocyte membrane FA content in kidney transplant recipients (KTP). We sought to test the hypothesis that erythrocyte membrane FA content among KTP were different from those in dialysis patients. METHODS: In this cross-sectional study, we recruited 35 hemodialysis, 33 peritoneal dialysis 49 KTP, and 33 normal control subjects (CTL). Their erythrocyte membrane FA content were measured by gas chromatography. RESULTS: The mean ages of the enrolled dialysis patients, KTP, and CTL were 56.4 ± 10.1, 48.9 ± 10.4, and 49.5 ± 8.3 years, respectively. Mean kidney transplant duration was 89.8 ± 64.8 months and mean dialysis duration, 49.0 ± 32.6 months. The intakes of vegetable lipid and vegetable protein including total calories were significantly increased among KTP versus dialysis patients. Total cholesterol (P < .001) and high density lipoprotein cholesterol (HDL; P < .001) levels were significantly higher and C-reactive protein was significantly lower among KTP compared with dialysis patients. The erythrocyte membrane content of palmitoleic acid (P < .001) was significantly higher but oleic acid (P < .001) significantly lower in KTP compared with dialysis patients. The erythrocyte membrane contents of arachidonic acid and docosahexaenoic acid were significantly higher, and linoleic acid and the omega-6 FA to omega-3 FA ratio (P < .001) significantly lower in KTP compared with dialysis patients. The erythrocyte membrane content of oleic acid was independently associated with monounsaturated fatty acid (beta = 0.771, P < .001), eicosapentaeonic acid (beta = -0.244, P = .010), and HDL (beta = -0.139, P = .049) in KTP. CONCLUSIONS: FA contents of erythrocyte membranes were significantly different in KTP compared with dialysis patients. These differences may have been associated with improved dietary intake and immunosuppression after kidney transplantation. SN - 1873-2623 UR - https://www.unboundmedicine.com/medline/citation/23195000/Comparison_of_erythrocyte_membrane_fatty_acid_contents_in_renal_transplant_recipients_and_dialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(12)00972-4 DB - PRIME DP - Unbound Medicine ER -