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Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden.
Cancer Epidemiol Biomarkers Prev. 2013 Feb; 22(2):308-12.CE

Abstract

High intake of phytoestrogen lignans has been found to be associated with decreased risk of esophageal adenocarcinoma in our previous population-based case-control study in Sweden. To further evaluate this possible association, we tested the hypothesis of an inverse association between dietary lignan intake and risk of esophageal and gastric adenocarcinoma using a prospective design. In a population-based cohort study in Sweden, 81,670 participants who were cancer-free at baseline were followed up during 1998 to 2009. All participants completed a 96-item food frequency questionnaire (FFQ), which was used to assess dietary exposure to lignans (secoisolariciresinol, matairesinol, lariciresinol, pinoresinol, medioresinol, and syringaresinol). All cases of esophageal, gastroesophageal junctional, and gastric adenocarcinoma were identified through linkage to the Swedish Cancer Register. Cox proportional hazard models were used to estimate HRs and 95% confidence intervals (CI), with adjustment for potential confounding factors. During an average follow-up of 9.9 years, a total of 211 cases were identified, including 83 cases of esophageal or junctional adenocarcinoma, and 128 cases of gastric adenocarcinoma. There was no statistically significant association between dietary intake of lignans and any of the studied adenocarcinomas. Compared with participants in the lowest quartile of lignan intake, the adjusted HR of the highest quartile was 0.96 (95% CI, 0.46-2.00; P(trend) = 0.70) for adenocarcinoma of the esophagus or gastroesophageal junction, and 0.89 (95% CI, 0.52-1.55: P(trend) = 0.78) for gastric adenocarcinoma. No clear support for a protective role of dietary intake of lignans in the development of esophageal or gastric adenocarcinoma was found.

Authors+Show Affiliations

Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. yulan.lin@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23195991

Citation

Lin, Yulan, et al. "Dietary Intake of Lignans and Risk of Esophageal and Gastric Adenocarcinoma: a Cohort Study in Sweden." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 22, no. 2, 2013, pp. 308-12.
Lin Y, Wolk A, Håkansson N, et al. Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden. Cancer Epidemiol Biomarkers Prev. 2013;22(2):308-12.
Lin, Y., Wolk, A., Håkansson, N., Lagergren, J., & Lu, Y. (2013). Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 22(2), 308-12. https://doi.org/10.1158/1055-9965.EPI-12-1138
Lin Y, et al. Dietary Intake of Lignans and Risk of Esophageal and Gastric Adenocarcinoma: a Cohort Study in Sweden. Cancer Epidemiol Biomarkers Prev. 2013;22(2):308-12. PubMed PMID: 23195991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden. AU - Lin,Yulan, AU - Wolk,Alicja, AU - Håkansson,Niclas, AU - Lagergren,Jesper, AU - Lu,Yunxia, Y1 - 2012/11/28/ PY - 2012/12/1/entrez PY - 2012/12/1/pubmed PY - 2013/7/24/medline SP - 308 EP - 12 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 22 IS - 2 N2 - High intake of phytoestrogen lignans has been found to be associated with decreased risk of esophageal adenocarcinoma in our previous population-based case-control study in Sweden. To further evaluate this possible association, we tested the hypothesis of an inverse association between dietary lignan intake and risk of esophageal and gastric adenocarcinoma using a prospective design. In a population-based cohort study in Sweden, 81,670 participants who were cancer-free at baseline were followed up during 1998 to 2009. All participants completed a 96-item food frequency questionnaire (FFQ), which was used to assess dietary exposure to lignans (secoisolariciresinol, matairesinol, lariciresinol, pinoresinol, medioresinol, and syringaresinol). All cases of esophageal, gastroesophageal junctional, and gastric adenocarcinoma were identified through linkage to the Swedish Cancer Register. Cox proportional hazard models were used to estimate HRs and 95% confidence intervals (CI), with adjustment for potential confounding factors. During an average follow-up of 9.9 years, a total of 211 cases were identified, including 83 cases of esophageal or junctional adenocarcinoma, and 128 cases of gastric adenocarcinoma. There was no statistically significant association between dietary intake of lignans and any of the studied adenocarcinomas. Compared with participants in the lowest quartile of lignan intake, the adjusted HR of the highest quartile was 0.96 (95% CI, 0.46-2.00; P(trend) = 0.70) for adenocarcinoma of the esophagus or gastroesophageal junction, and 0.89 (95% CI, 0.52-1.55: P(trend) = 0.78) for gastric adenocarcinoma. No clear support for a protective role of dietary intake of lignans in the development of esophageal or gastric adenocarcinoma was found. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/23195991/Dietary_intake_of_lignans_and_risk_of_esophageal_and_gastric_adenocarcinoma:_a_cohort_study_in_Sweden_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=23195991 DB - PRIME DP - Unbound Medicine ER -