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[Modification of degenerative and regenerative processes in peripheral nerves by treatment with B vitamins].
Klin Wochenschr. 1990 Jan 19; 68(2):146-8.KW

Abstract

Degenerative and regenerative changes in the saphenous nerve of the rabbit following systemic treatment with either a combination of the vitamins B1, B6 and B12 or physiological saline solution were investigated. Cold lesion of the nerve (-196 degrees C), which led to an optimal axonotmesis, was used to cause a secondary degeneration. The nerves were removed and investigated by light and electron microscopy after 4, 10 and 21 days. Morphological results show that the number of regenerating axons is higher and that of degenerating axons lower in the group treated with the given doses of vitamins than in the comparable control group. An explanation of the underlying metabolic processes is as yet not possible. Further investigations considering the contribution of the individual vitamins to the enhancement of degenerative and regenerative processes are necessary. Clinical indications of neurotoxicity due to the dose levels used here were not observed.

Authors+Show Affiliations

Kienecker EW
Fachrichtung 3.1-Anatomie, Universität des Saarlandes, Homburg/Saar.
Becker KW
No affiliation info available
Dick P
No affiliation info available

MeSH

AnimalsAxonsHindlimbMicroscopy, ElectronNerve DegenerationNerve RegenerationPeripheral NervesRabbitsVitamin B Complex

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

2319732

Citation

Kienecker, E W., et al. "[Modification of Degenerative and Regenerative Processes in Peripheral Nerves By Treatment With B Vitamins]." Klinische Wochenschrift, vol. 68, no. 2, 1990, pp. 146-8.
Kienecker EW, Becker KW, Dick P. [Modification of degenerative and regenerative processes in peripheral nerves by treatment with B vitamins]. Klin Wochenschr. 1990;68(2):146-8.
Kienecker, E. W., Becker, K. W., & Dick, P. (1990). [Modification of degenerative and regenerative processes in peripheral nerves by treatment with B vitamins]. Klinische Wochenschrift, 68(2), 146-8.
Kienecker EW, Becker KW, Dick P. [Modification of Degenerative and Regenerative Processes in Peripheral Nerves By Treatment With B Vitamins]. Klin Wochenschr. 1990 Jan 19;68(2):146-8. PubMed PMID: 2319732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Modification of degenerative and regenerative processes in peripheral nerves by treatment with B vitamins]. AU - Kienecker,E W, AU - Becker,K W, AU - Dick,P, PY - 1990/1/19/pubmed PY - 1990/1/19/medline PY - 1990/1/19/entrez SP - 146 EP - 8 JF - Klinische Wochenschrift JO - Klin Wochenschr VL - 68 IS - 2 N2 - Degenerative and regenerative changes in the saphenous nerve of the rabbit following systemic treatment with either a combination of the vitamins B1, B6 and B12 or physiological saline solution were investigated. Cold lesion of the nerve (-196 degrees C), which led to an optimal axonotmesis, was used to cause a secondary degeneration. The nerves were removed and investigated by light and electron microscopy after 4, 10 and 21 days. Morphological results show that the number of regenerating axons is higher and that of degenerating axons lower in the group treated with the given doses of vitamins than in the comparable control group. An explanation of the underlying metabolic processes is as yet not possible. Further investigations considering the contribution of the individual vitamins to the enhancement of degenerative and regenerative processes are necessary. Clinical indications of neurotoxicity due to the dose levels used here were not observed. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2319732/[Modification_of_degenerative_and_regenerative_processes_in_peripheral_nerves_by_treatment_with_B_vitamins]_ L2 - https://medlineplus.gov/bvitamins.html DB - PRIME DP - Unbound Medicine ER -