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Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population.
Nephrol Dial Transplant. 2013 Mar; 28(3):641-51.ND

Abstract

BACKGROUND

Previous studies have indicated that the performance of glomerular filtration rate (GFR) estimation equations vary according to the races of the target population. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has not been validated in the Chinese population including patients with chronic kidney disease (CKD) and healthy controls.

METHODS

A total of 977 adult persons (682 patients with CKD and 295 healthy volunteers) from nine renal institutes of university hospitals located in nine geographic regions of China were enrolled in the study. A diagnostic test study comparing the CKD-EPI two-level and four-level race equation, the Modification of Diet in Renal Disease (MDRD) Study equation and the modified MDRD equation for Chinese (the Chinese equation). The (99m)Tc- diethylenetriamine pentaacetic acid dual plasma clearance was used as a reference method for measuring GFR.

RESULTS

The mean age of participants was 48.3 ± 16.0 years and 479 (49.0%) were male. The CKD-EPI two-level race equation and the Chinese equation performed better than the MDRD Study equation and CKD-EPI four-level race equation, with less bias (median difference between estimated GFR and reference GFR, 0.2 and 0.3 versus -2.4 and 3.0 mL/min/1.73 m(2)), improved precision (interquartile range of the difference, 20.5 and 20.8 versus 23.4 and 20.5 mL/min/1.73 m(2)) and greater accuracy (percentage of estimated GFR within 30% of reference GFR, 73.4 and 73.0% versus 69.8 and 70.1%).

CONCLUSIONS

The CKD-EPI two-level race equation and the Chinese equation performed similarly in the Chinese population, and both performed better than the MDRD Study equation and the CKD-EPI four-level race equation.

Authors+Show Affiliations

Department of Medicine, Peking University First Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23197682

Citation

Kong, Xianglei, et al. "Evaluation of the Chronic Kidney Disease Epidemiology Collaboration Equation for Estimating Glomerular Filtration Rate in the Chinese Population." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 28, no. 3, 2013, pp. 641-51.
Kong X, Ma Y, Chen J, et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population. Nephrol Dial Transplant. 2013;28(3):641-51.
Kong, X., Ma, Y., Chen, J., Luo, Q., Yu, X., Li, Y., Xu, J., Huang, S., Wang, L., Huang, W., Wang, M., Xu, G., Zhang, L., Zuo, L., & Wang, H. (2013). Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 28(3), 641-51. https://doi.org/10.1093/ndt/gfs491
Kong X, et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration Equation for Estimating Glomerular Filtration Rate in the Chinese Population. Nephrol Dial Transplant. 2013;28(3):641-51. PubMed PMID: 23197682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population. AU - Kong,Xianglei, AU - Ma,Yingchun, AU - Chen,Jianghua, AU - Luo,Qiong, AU - Yu,Xueqing, AU - Li,Ying, AU - Xu,Jinsheng, AU - Huang,Songmin, AU - Wang,Lining, AU - Huang,Wen, AU - Wang,Mei, AU - Xu,Guobin, AU - Zhang,Luxia, AU - Zuo,Li, AU - Wang,Haiyan, AU - ,, Y1 - 2012/11/29/ PY - 2012/12/1/entrez PY - 2012/12/1/pubmed PY - 2013/9/27/medline SP - 641 EP - 51 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 28 IS - 3 N2 - BACKGROUND: Previous studies have indicated that the performance of glomerular filtration rate (GFR) estimation equations vary according to the races of the target population. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has not been validated in the Chinese population including patients with chronic kidney disease (CKD) and healthy controls. METHODS: A total of 977 adult persons (682 patients with CKD and 295 healthy volunteers) from nine renal institutes of university hospitals located in nine geographic regions of China were enrolled in the study. A diagnostic test study comparing the CKD-EPI two-level and four-level race equation, the Modification of Diet in Renal Disease (MDRD) Study equation and the modified MDRD equation for Chinese (the Chinese equation). The (99m)Tc- diethylenetriamine pentaacetic acid dual plasma clearance was used as a reference method for measuring GFR. RESULTS: The mean age of participants was 48.3 ± 16.0 years and 479 (49.0%) were male. The CKD-EPI two-level race equation and the Chinese equation performed better than the MDRD Study equation and CKD-EPI four-level race equation, with less bias (median difference between estimated GFR and reference GFR, 0.2 and 0.3 versus -2.4 and 3.0 mL/min/1.73 m(2)), improved precision (interquartile range of the difference, 20.5 and 20.8 versus 23.4 and 20.5 mL/min/1.73 m(2)) and greater accuracy (percentage of estimated GFR within 30% of reference GFR, 73.4 and 73.0% versus 69.8 and 70.1%). CONCLUSIONS: The CKD-EPI two-level race equation and the Chinese equation performed similarly in the Chinese population, and both performed better than the MDRD Study equation and the CKD-EPI four-level race equation. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/23197682/Evaluation_of_the_Chronic_Kidney_Disease_Epidemiology_Collaboration_equation_for_estimating_glomerular_filtration_rate_in_the_Chinese_population_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfs491 DB - PRIME DP - Unbound Medicine ER -