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Calcium, magnesium and potassium intake and mortality in women with heart failure: the Women's Health Initiative.
Br J Nutr. 2013 Jul 14; 110(1):179-85.BJ

Abstract

Although diet is thought to affect the natural history of heart failure (HF), nutrient intake in HF patients has not been well studied. Based on prior research linking high intake of Ca, Mg and K to improved cardiovascular health, we hypothesised that these nutrients would be inversely associated with mortality in people with HF. Of the 161 808 participants in the Women's Health Initiative (WHI), we studied 3340 who experienced a HF hospitalisation. These participants were followed for post-hospitalisation all-cause mortality. Intake was assessed using questionnaires on food and supplement intake. Hazard ratios (HR) and 95 % CI were calculated using Cox proportional hazards models adjusted for demographics, physical function, co-morbidities and dietary covariates. Over a median of 4·6 years of follow-up, 1433 (42·9 %) of the women died. HR across quartiles of dietary Ca intake were 1·00 (referent), 0·86 (95 % CI 0·73, 1·00), 0·88 (95 % CI 0·75, 1·04) and 0·92 (95 % CI 0·76, 1·11) (P for trend = 0·63). Corresponding HR were 1·00 (referent), 0·86 (95 % CI 0·71, 1·04), 0·88 (95 % CI 0·69, 1·11) and 0·84 (95 % CI 0·63, 1·12) (P for trend = 0·29), across quartiles of dietary Mg intake, and 1·00 (referent), 1·20 (95 % CI 1·01, 1·43), 1·06 (95 % CI 0·86, 1·32) and 1·16 (95 % CI 0·90, 1·51) (P for trend = 0·35), across quartiles of dietary K intake. Results were similar when total (dietary plus supplemental) nutrient intakes were examined. In summary, among WHI participants with incident HF hospitalisation, intakes of Ca, Mg and K were not significantly associated with subsequent mortality.

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Authors+Show Affiliations

Levitan EB
University of Alabama at Birmingham, Department of Epidemiology, 1530 3rd Avenue South, RPHB 230K, Birmingham, AL 35924-0022, USA. elevitan@uab.edu
Shikany JM
No affiliation info available
Ahmed A
No affiliation info available
Snetselaar LG
No affiliation info available
Martin LW
No affiliation info available
Curb JD
No affiliation info available
Lewis CE
No affiliation info available

MeSH

AgedCalciumCalcium, DietaryConfidence IntervalsDietDietary SupplementsEnergy IntakeFemaleHeart FailureHospitalizationHumansMagnesiumMiddle AgedPotassiumProportional Hazards ModelsRisk FactorsTrace Elements

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23199414

Citation

Levitan, Emily B., et al. "Calcium, Magnesium and Potassium Intake and Mortality in Women With Heart Failure: the Women's Health Initiative." The British Journal of Nutrition, vol. 110, no. 1, 2013, pp. 179-85.
Levitan EB, Shikany JM, Ahmed A, et al. Calcium, magnesium and potassium intake and mortality in women with heart failure: the Women's Health Initiative. Br J Nutr. 2013;110(1):179-85.
Levitan, E. B., Shikany, J. M., Ahmed, A., Snetselaar, L. G., Martin, L. W., Curb, J. D., & Lewis, C. E. (2013). Calcium, magnesium and potassium intake and mortality in women with heart failure: the Women's Health Initiative. The British Journal of Nutrition, 110(1), 179-85. https://doi.org/10.1017/S0007114512004667
Levitan EB, et al. Calcium, Magnesium and Potassium Intake and Mortality in Women With Heart Failure: the Women's Health Initiative. Br J Nutr. 2013 Jul 14;110(1):179-85. PubMed PMID: 23199414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium, magnesium and potassium intake and mortality in women with heart failure: the Women's Health Initiative. AU - Levitan,Emily B, AU - Shikany,James M, AU - Ahmed,Ali, AU - Snetselaar,Linda G, AU - Martin,Lisa W, AU - Curb,J David, AU - Lewis,Cora E, Y1 - 2012/11/19/ PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/8/6/medline SP - 179 EP - 85 JF - The British journal of nutrition JO - Br J Nutr VL - 110 IS - 1 N2 - Although diet is thought to affect the natural history of heart failure (HF), nutrient intake in HF patients has not been well studied. Based on prior research linking high intake of Ca, Mg and K to improved cardiovascular health, we hypothesised that these nutrients would be inversely associated with mortality in people with HF. Of the 161 808 participants in the Women's Health Initiative (WHI), we studied 3340 who experienced a HF hospitalisation. These participants were followed for post-hospitalisation all-cause mortality. Intake was assessed using questionnaires on food and supplement intake. Hazard ratios (HR) and 95 % CI were calculated using Cox proportional hazards models adjusted for demographics, physical function, co-morbidities and dietary covariates. Over a median of 4·6 years of follow-up, 1433 (42·9 %) of the women died. HR across quartiles of dietary Ca intake were 1·00 (referent), 0·86 (95 % CI 0·73, 1·00), 0·88 (95 % CI 0·75, 1·04) and 0·92 (95 % CI 0·76, 1·11) (P for trend = 0·63). Corresponding HR were 1·00 (referent), 0·86 (95 % CI 0·71, 1·04), 0·88 (95 % CI 0·69, 1·11) and 0·84 (95 % CI 0·63, 1·12) (P for trend = 0·29), across quartiles of dietary Mg intake, and 1·00 (referent), 1·20 (95 % CI 1·01, 1·43), 1·06 (95 % CI 0·86, 1·32) and 1·16 (95 % CI 0·90, 1·51) (P for trend = 0·35), across quartiles of dietary K intake. Results were similar when total (dietary plus supplemental) nutrient intakes were examined. In summary, among WHI participants with incident HF hospitalisation, intakes of Ca, Mg and K were not significantly associated with subsequent mortality. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/23199414/Calcium_magnesium_and_potassium_intake_and_mortality_in_women_with_heart_failure:_the_Women's_Health_Initiative_ L2 - https://www.cambridge.org/core/product/identifier/S0007114512004667/type/journal_article DB - PRIME DP - Unbound Medicine ER -