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Acute and sub-chronic (28days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals.
Food Chem Toxicol. 2013 Feb; 52:176-9.FC

Abstract

The present investigation was carried out to evaluate the safety of hydro-ethanol extract of Bridelia ferruginea Benth (Euphorbiaceae) root bark. For acute toxicity study, a single dose of 2000 and 5000 mg/kg of the B. ferruginea root bark extract was given orally to healthy male Wistar rats and Balb/c mice. The animals were observed for mortality and clinical signs for 3 h and then daily for 14 days. In the sub-chronic toxicity study, the extract was administered orally at doses of 250, 500 and 1000 mg/kg/day for 28 days to male Wistar rats. Animals were sacrificed to examine their organs, and urine and blood serum were analyzed. In the acute toxicity study, B. ferruginea root bark extract caused neither significant visible signs of toxicity, nor mortality in Wistar rats and Balb/c mice. In sub-chronic toxicity study, administration of the B. ferruginea root bark extract at 250, 500, and 1000 mg/kg for 28 consecutive days to Wistar rats did not produce mortality. No significant differences were found in relative organ weights, biochemical studied parameters in treated groups compared to control group. No obvious histological changes were observed in organs of B. ferruginea extract treated animals compared to controls.

Authors+Show Affiliations

Department of Animal Physiology, Faculty of Sciences, University of Lome, Lome, Togo. bbakoma@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23201452

Citation

Bakoma, Batomayena, et al. "Acute and Sub-chronic (28days) Oral Toxicity Evaluation of Hydroethanolic Extract of Bridelia Ferruginea Benth Root Bark in Male Rodent Animals." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 52, 2013, pp. 176-9.
Bakoma B, Berké B, Eklu-Gadegbeku K, et al. Acute and sub-chronic (28days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals. Food Chem Toxicol. 2013;52:176-9.
Bakoma, B., Berké, B., Eklu-Gadegbeku, K., Agbonon, A., Aklikokou, K., Gbeassor, M., Creppy, E. E., & Moore, N. (2013). Acute and sub-chronic (28days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 52, 176-9. https://doi.org/10.1016/j.fct.2012.11.021
Bakoma B, et al. Acute and Sub-chronic (28days) Oral Toxicity Evaluation of Hydroethanolic Extract of Bridelia Ferruginea Benth Root Bark in Male Rodent Animals. Food Chem Toxicol. 2013;52:176-9. PubMed PMID: 23201452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute and sub-chronic (28days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals. AU - Bakoma,Batomayena, AU - Berké,Bénédicte, AU - Eklu-Gadegbeku,Kwashie, AU - Agbonon,Amegnona, AU - Aklikokou,Kodjo, AU - Gbeassor,Messanvi, AU - Creppy,Edmond E, AU - Moore,Nicholas, Y1 - 2012/11/28/ PY - 2012/01/12/received PY - 2012/11/14/revised PY - 2012/11/16/accepted PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/9/7/medline SP - 176 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 52 N2 - The present investigation was carried out to evaluate the safety of hydro-ethanol extract of Bridelia ferruginea Benth (Euphorbiaceae) root bark. For acute toxicity study, a single dose of 2000 and 5000 mg/kg of the B. ferruginea root bark extract was given orally to healthy male Wistar rats and Balb/c mice. The animals were observed for mortality and clinical signs for 3 h and then daily for 14 days. In the sub-chronic toxicity study, the extract was administered orally at doses of 250, 500 and 1000 mg/kg/day for 28 days to male Wistar rats. Animals were sacrificed to examine their organs, and urine and blood serum were analyzed. In the acute toxicity study, B. ferruginea root bark extract caused neither significant visible signs of toxicity, nor mortality in Wistar rats and Balb/c mice. In sub-chronic toxicity study, administration of the B. ferruginea root bark extract at 250, 500, and 1000 mg/kg for 28 consecutive days to Wistar rats did not produce mortality. No significant differences were found in relative organ weights, biochemical studied parameters in treated groups compared to control group. No obvious histological changes were observed in organs of B. ferruginea extract treated animals compared to controls. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23201452/Acute_and_sub_chronic__28days__oral_toxicity_evaluation_of_hydroethanolic_extract_of_Bridelia_ferruginea_Benth_root_bark_in_male_rodent_animals_ DB - PRIME DP - Unbound Medicine ER -