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Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia.
J Clin Virol. 2013 Feb; 56(2):141-5.JC

Abstract

BACKGROUND

Chikungunya virus (CHIKV) and dengue virus (DENV) co-circulate in areas endemic with the Aedes mosquito vectors. Both viruses cause similar illnesses which may be difficult to distinguish clinically. CHIKV is also associated with persistent arthralgia.

OBJECTIVES

To compare and describe factors which differentiate between DENV and CHIKV infections on presentation; and to describe predictors of persistent arthralgia in CHIKV patients.

STUDY DESIGN

Patients aged >14 years diagnosed with acute CHIKV and DENV infections in Kuala Lumpur, Malaysia were retrospectively identified. Clinical and laboratory data were obtained from medical records, and compared. CHIKV patients were telephoned 15-24 months later and interviewed about persistent symptoms. Logistic regression analysis was performed.

RESULTS

A total of 53 CHIKV and 113 DENV patients were included. CHIKV patients were older and more likely to be female. CHIKV was independently associated with arthralgia and rash, while DENV was associated with myalgia, raised aspartate transaminase, and leucopaenia. Forty CHIKV patients were followed up, with a median duration of self-reported arthralgia of 3 months (range, 0-24 months). Eighteen (45%) had persistent arthralgia beyond 4 months, for which age >40 years was an independent predictor. At 1 year, 9 (22.5%) patients had arthralgia.

CONCLUSION

In Kuala Lumpur, selected clinical and laboratory predictors help to distinguish between DENV and CHIKV infections. Persistent arthralgia was a frequent sequel of CHIKV infection in this cohort.

Authors+Show Affiliations

Department of Medicine, Universiti Teknologi MARA, Shah Alam, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23201456

Citation

Mohd Zim, M A., et al. "Chikungunya Infection in Malaysia: Comparison With Dengue Infection in Adults and Predictors of Persistent Arthralgia." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 56, no. 2, 2013, pp. 141-5.
Mohd Zim MA, Sam IC, Omar SF, et al. Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia. J Clin Virol. 2013;56(2):141-5.
Mohd Zim, M. A., Sam, I. C., Omar, S. F., Chan, Y. F., AbuBakar, S., & Kamarulzaman, A. (2013). Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 56(2), 141-5. https://doi.org/10.1016/j.jcv.2012.10.019
Mohd Zim MA, et al. Chikungunya Infection in Malaysia: Comparison With Dengue Infection in Adults and Predictors of Persistent Arthralgia. J Clin Virol. 2013;56(2):141-5. PubMed PMID: 23201456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia. AU - Mohd Zim,M A, AU - Sam,I-C, AU - Omar,S F Syed, AU - Chan,Y F, AU - AbuBakar,S, AU - Kamarulzaman,A, Y1 - 2012/11/30/ PY - 2012/04/10/received PY - 2012/10/02/revised PY - 2012/10/30/accepted PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/6/20/medline SP - 141 EP - 5 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 56 IS - 2 N2 - BACKGROUND: Chikungunya virus (CHIKV) and dengue virus (DENV) co-circulate in areas endemic with the Aedes mosquito vectors. Both viruses cause similar illnesses which may be difficult to distinguish clinically. CHIKV is also associated with persistent arthralgia. OBJECTIVES: To compare and describe factors which differentiate between DENV and CHIKV infections on presentation; and to describe predictors of persistent arthralgia in CHIKV patients. STUDY DESIGN: Patients aged >14 years diagnosed with acute CHIKV and DENV infections in Kuala Lumpur, Malaysia were retrospectively identified. Clinical and laboratory data were obtained from medical records, and compared. CHIKV patients were telephoned 15-24 months later and interviewed about persistent symptoms. Logistic regression analysis was performed. RESULTS: A total of 53 CHIKV and 113 DENV patients were included. CHIKV patients were older and more likely to be female. CHIKV was independently associated with arthralgia and rash, while DENV was associated with myalgia, raised aspartate transaminase, and leucopaenia. Forty CHIKV patients were followed up, with a median duration of self-reported arthralgia of 3 months (range, 0-24 months). Eighteen (45%) had persistent arthralgia beyond 4 months, for which age >40 years was an independent predictor. At 1 year, 9 (22.5%) patients had arthralgia. CONCLUSION: In Kuala Lumpur, selected clinical and laboratory predictors help to distinguish between DENV and CHIKV infections. Persistent arthralgia was a frequent sequel of CHIKV infection in this cohort. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/23201456/Chikungunya_infection_in_Malaysia:_comparison_with_dengue_infection_in_adults_and_predictors_of_persistent_arthralgia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(12)00407-6 DB - PRIME DP - Unbound Medicine ER -