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Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.
Colloids Surf B Biointerfaces. 2013 Mar 01; 103:189-99.CS

Abstract

Piroxicam is a non-steroidal anti-inflammatory drug that is characterised by low solubility and high permeability. In order to improve the drug dissolution rate, the co-grinding method was used as an approach to prepare piroxicam co-ground in the carriers such as glucosamine hydrochloride. As, this amino sugar (glucosamine HCl) has been shown to decrease pain and improve mobility in osteoarthritis in joints, therefore, the incorporation of glucosamine in piroxicam formulations would be expected to offer additional benefits to patients. The effect of the order of grinding on the dissolution of piroxicam was also investigated. Co-ground drug and glucosamine were prepared in different ratios using a ball mill. The samples were then subjected to different grinding times. In order to investigate the effect of the grinding process on the dissolution behaviour of piroxicam, the drug was ground separately in the absence of glucosamine. Mixtures of ground piroxicam and unground D-glucosamine HCl were prepared. Physical mixtures of piroxicam and glucosamine were also prepared for comparison. The properties of prepared co-ground systems and physical mixtures were studied using a dissolution tester, FTIR, SEM, XRPD and DSC. These results showed that the presence of glucosamine HCl can increase dissolution rate of piroxicam compared to pure piroxicam. Generally, all dissolution profiles showed the fastest dissolution rate when ground piroxicam was mixed with unground glucosamine. This was closely followed by the co-grinding of piroxicam with glucosamine where lower grinding times showed the fastest dissolution. The solid state studies showed that the grinding of piroxicam for longer times had no effect on polymorphic form of piroxicam, whereas mixtures of piroxicam-glucosamine ground for longer times (60 min) converted piroxicam polymorph II to polymorph I.

Authors+Show Affiliations

Medway School of Pharmacy, Universities of Kent, Central Avenue, Kent ME4 4TB, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23201737

Citation

Al-Hamidi, Hiba, et al. "Effect of Glucosamine HCl On Dissolution and Solid State Behaviours of Piroxicam Upon Milling." Colloids and Surfaces. B, Biointerfaces, vol. 103, 2013, pp. 189-99.
Al-Hamidi H, Edwards AA, Douroumis D, et al. Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling. Colloids Surf B Biointerfaces. 2013;103:189-99.
Al-Hamidi, H., Edwards, A. A., Douroumis, D., Asare-Addo, K., Nayebi, A. M., Reyhani-Rad, S., Mahmoudi, J., & Nokhodchi, A. (2013). Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling. Colloids and Surfaces. B, Biointerfaces, 103, 189-99. https://doi.org/10.1016/j.colsurfb.2012.10.023
Al-Hamidi H, et al. Effect of Glucosamine HCl On Dissolution and Solid State Behaviours of Piroxicam Upon Milling. Colloids Surf B Biointerfaces. 2013 Mar 1;103:189-99. PubMed PMID: 23201737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling. AU - Al-Hamidi,Hiba, AU - Edwards,Alison A, AU - Douroumis,Dionysis, AU - Asare-Addo,Kofi, AU - Nayebi,Alireza Mohajjel, AU - Reyhani-Rad,Siamak, AU - Mahmoudi,Javad, AU - Nokhodchi,Ali, Y1 - 2012/11/05/ PY - 2012/07/26/received PY - 2012/09/14/revised PY - 2012/10/10/accepted PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/8/2/medline SP - 189 EP - 99 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 103 N2 - Piroxicam is a non-steroidal anti-inflammatory drug that is characterised by low solubility and high permeability. In order to improve the drug dissolution rate, the co-grinding method was used as an approach to prepare piroxicam co-ground in the carriers such as glucosamine hydrochloride. As, this amino sugar (glucosamine HCl) has been shown to decrease pain and improve mobility in osteoarthritis in joints, therefore, the incorporation of glucosamine in piroxicam formulations would be expected to offer additional benefits to patients. The effect of the order of grinding on the dissolution of piroxicam was also investigated. Co-ground drug and glucosamine were prepared in different ratios using a ball mill. The samples were then subjected to different grinding times. In order to investigate the effect of the grinding process on the dissolution behaviour of piroxicam, the drug was ground separately in the absence of glucosamine. Mixtures of ground piroxicam and unground D-glucosamine HCl were prepared. Physical mixtures of piroxicam and glucosamine were also prepared for comparison. The properties of prepared co-ground systems and physical mixtures were studied using a dissolution tester, FTIR, SEM, XRPD and DSC. These results showed that the presence of glucosamine HCl can increase dissolution rate of piroxicam compared to pure piroxicam. Generally, all dissolution profiles showed the fastest dissolution rate when ground piroxicam was mixed with unground glucosamine. This was closely followed by the co-grinding of piroxicam with glucosamine where lower grinding times showed the fastest dissolution. The solid state studies showed that the grinding of piroxicam for longer times had no effect on polymorphic form of piroxicam, whereas mixtures of piroxicam-glucosamine ground for longer times (60 min) converted piroxicam polymorph II to polymorph I. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/23201737/Effect_of_glucosamine_HCl_on_dissolution_and_solid_state_behaviours_of_piroxicam_upon_milling_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(12)00580-2 DB - PRIME DP - Unbound Medicine ER -