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Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes.
Nutrients. 2012 Nov 14; 4(11):1747-58.N

Abstract

Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes.

Authors+Show Affiliations

School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia. christina.west@pediatri.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23201845

Citation

West, Christina E., et al. "Associations Between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes." Nutrients, vol. 4, no. 11, 2012, pp. 1747-58.
West CE, Dunstan J, McCarthy S, et al. Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. Nutrients. 2012;4(11):1747-58.
West, C. E., Dunstan, J., McCarthy, S., Metcalfe, J., D'Vaz, N., Meldrum, S., Oddy, W. H., Tulic, M. K., & Prescott, S. L. (2012). Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. Nutrients, 4(11), 1747-58. https://doi.org/10.3390/nu4111747
West CE, et al. Associations Between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes. Nutrients. 2012 Nov 14;4(11):1747-58. PubMed PMID: 23201845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. AU - West,Christina E, AU - Dunstan,Janet, AU - McCarthy,Suzi, AU - Metcalfe,Jessica, AU - D'Vaz,Nina, AU - Meldrum,Suzanne, AU - Oddy,Wendy H, AU - Tulic,Meri K, AU - Prescott,Susan L, Y1 - 2012/11/14/ PY - 2012/09/17/received PY - 2012/11/07/revised PY - 2012/11/08/accepted PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/5/7/medline SP - 1747 EP - 58 JF - Nutrients JO - Nutrients VL - 4 IS - 11 N2 - Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/23201845/Associations_between_maternal_antioxidant_intakes_in_pregnancy_and_infant_allergic_outcomes_ L2 - https://www.mdpi.com/resolver?pii=nu4111747 DB - PRIME DP - Unbound Medicine ER -