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Effect of soy protein and isoflavones on blood pressure and endothelial cytokines: a 6-month randomized controlled trial among postmenopausal women.
J Hypertens. 2013 Feb; 31(2):384-92.JH

Abstract

BACKGROUND

Despite data from animal models and observational studies that are generally supportive for the soy/isoflavones lowering blood pressure (BP) and improving vascular function, the current findings from clinical trials are still inconclusive.

OBJECTIVES

To examine whether soy protein with isoflavones or isoflavones alone reduce BP and endothelial cytokines, and whether the effects differed by baseline BP level.

METHODS

A double-blind randomized, placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. Participants were randomly assigned to one of the three arms to receive either 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months.

RESULTS

No significant difference was observed in the change and %change of BP and endothelial cytokine levels among the three study groups. However, a subgroup analysis among 130 pre and hypertensive women suggested that soy protein and isoflavones significantly reduced SBP [-4.25%, 95% confidence interval (CI) -7.9 to -0.6%, P = 0.02] and the level of soluble intercellular adhesion molecule (sICAM)-1 (-22.6%, 95% CI -42.8 to -2.3%, P = 0.02) relative to milk protein after 6-month intervention.

CONCLUSIONS

: Our 6-month randomized controlled trial in prediabetic postmenopausal women indicated that soy protein and isoflavones had no significant effect on BP and endothelial molecules; however, a favorable reduction on SBP, sICAM-1 and E-selectin was observed among women with initial elevated BP.

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Authors+Show Affiliations

Liu ZM
Department of Medicine &Therapeutics, The Jackey Club of School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong.
Ho SC
No affiliation info available
Chen YM
No affiliation info available
Woo J
No affiliation info available

MeSH

BiomarkersBlood PressureCytokinesDietDouble-Blind MethodExerciseFemaleHumansIsoflavonesMiddle AgedPatient CompliancePlacebosPostmenopauseSoybean Proteins

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23203140

Citation

Liu, Zhao-Min, et al. "Effect of Soy Protein and Isoflavones On Blood Pressure and Endothelial Cytokines: a 6-month Randomized Controlled Trial Among Postmenopausal Women." Journal of Hypertension, vol. 31, no. 2, 2013, pp. 384-92.
Liu ZM, Ho SC, Chen YM, et al. Effect of soy protein and isoflavones on blood pressure and endothelial cytokines: a 6-month randomized controlled trial among postmenopausal women. J Hypertens. 2013;31(2):384-92.
Liu, Z. M., Ho, S. C., Chen, Y. M., & Woo, J. (2013). Effect of soy protein and isoflavones on blood pressure and endothelial cytokines: a 6-month randomized controlled trial among postmenopausal women. Journal of Hypertension, 31(2), 384-92. https://doi.org/10.1097/HJH.0b013e32835c0905
Liu ZM, et al. Effect of Soy Protein and Isoflavones On Blood Pressure and Endothelial Cytokines: a 6-month Randomized Controlled Trial Among Postmenopausal Women. J Hypertens. 2013;31(2):384-92. PubMed PMID: 23203140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of soy protein and isoflavones on blood pressure and endothelial cytokines: a 6-month randomized controlled trial among postmenopausal women. AU - Liu,Zhao-Min, AU - Ho,Suzanne C, AU - Chen,Yu-Ming, AU - Woo,Jean, PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/7/3/medline SP - 384 EP - 92 JF - Journal of hypertension JO - J Hypertens VL - 31 IS - 2 N2 - BACKGROUND: Despite data from animal models and observational studies that are generally supportive for the soy/isoflavones lowering blood pressure (BP) and improving vascular function, the current findings from clinical trials are still inconclusive. OBJECTIVES: To examine whether soy protein with isoflavones or isoflavones alone reduce BP and endothelial cytokines, and whether the effects differed by baseline BP level. METHODS: A double-blind randomized, placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. Participants were randomly assigned to one of the three arms to receive either 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months. RESULTS: No significant difference was observed in the change and %change of BP and endothelial cytokine levels among the three study groups. However, a subgroup analysis among 130 pre and hypertensive women suggested that soy protein and isoflavones significantly reduced SBP [-4.25%, 95% confidence interval (CI) -7.9 to -0.6%, P = 0.02] and the level of soluble intercellular adhesion molecule (sICAM)-1 (-22.6%, 95% CI -42.8 to -2.3%, P = 0.02) relative to milk protein after 6-month intervention. CONCLUSIONS: : Our 6-month randomized controlled trial in prediabetic postmenopausal women indicated that soy protein and isoflavones had no significant effect on BP and endothelial molecules; however, a favorable reduction on SBP, sICAM-1 and E-selectin was observed among women with initial elevated BP. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/23203140/Effect_of_soy_protein_and_isoflavones_on_blood_pressure_and_endothelial_cytokines:_a_6_month_randomized_controlled_trial_among_postmenopausal_women_ L2 - https://doi.org/10.1097/HJH.0b013e32835c0905 DB - PRIME DP - Unbound Medicine ER -