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Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.

Abstract

A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer's disease. This study investigated the frequency and severity of atherosclerotic plaques in the circle of Willis in Alzheimer's disease and multiple other neurodegenerative diseases. Semi-quantitative data from gross and microscopic neuropathological examinations in 1000 cases were analysed, including 410 with a primary diagnosis of Alzheimer's disease, 230 with synucleinopathies, 157 with TDP-43 proteinopathies, 144 with tauopathies and 59 with normal ageing. More than 77% of subjects with Alzheimer's disease had grossly apparent circle of Willis atherosclerosis, a percentage that was significantly higher than normal (47%), or other neurodegenerative diseases (43-67%). Age- and sex-adjusted atherosclerosis ratings were highly correlated with neuritic plaque, paired helical filaments tau neurofibrillary tangle and cerebral amyloid angiopathy ratings in the whole sample and within individual groups. We found no associations between atherosclerosis ratings and α-synuclein or TDP-43 lesion ratings. The association between age-adjusted circle of Willis atherosclerosis and Alzheimer's disease-type pathology was more robust for female subjects than male subjects. These results provide further confirmation and specificity that vascular disease and Alzheimer's disease are interrelated and suggest that common aetiologic or reciprocally synergistic pathophysiological mechanisms promote both vascular pathology and plaque and tangle pathology.

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    3615 Chestnut Street, Philadelphia, PA 19104, USA.

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    Source

    Brain : a journal of neurology 135:Pt 12 2012 Dec pg 3749-56

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Analysis of Variance
    Cerebral Amyloid Angiopathy
    Chi-Square Distribution
    Circle of Willis
    DNA-Binding Proteins
    Dementia
    Female
    Humans
    Intracranial Arteriosclerosis
    Male
    Middle Aged
    Neurodegenerative Diseases
    Neurofibrillary Tangles
    Retrospective Studies
    Risk Factors
    alpha-Synuclein

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23204143

    Citation

    Yarchoan, Mark, et al. "Cerebrovascular Atherosclerosis Correlates With Alzheimer Pathology in Neurodegenerative Dementias." Brain : a Journal of Neurology, vol. 135, no. Pt 12, 2012, pp. 3749-56.
    Yarchoan M, Xie SX, Kling MA, et al. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain. 2012;135(Pt 12):3749-56.
    Yarchoan, M., Xie, S. X., Kling, M. A., Toledo, J. B., Wolk, D. A., Lee, E. B., ... Arnold, S. E. (2012). Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain : a Journal of Neurology, 135(Pt 12), pp. 3749-56. doi:10.1093/brain/aws271.
    Yarchoan M, et al. Cerebrovascular Atherosclerosis Correlates With Alzheimer Pathology in Neurodegenerative Dementias. Brain. 2012;135(Pt 12):3749-56. PubMed PMID: 23204143.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. AU - Yarchoan,Mark, AU - Xie,Sharon X, AU - Kling,Mitchel A, AU - Toledo,Jon B, AU - Wolk,David A, AU - Lee,Edward B, AU - Van Deerlin,Vivianna, AU - Lee,Virginia M-Y, AU - Trojanowski,John Q, AU - Arnold,Steven E, Y1 - 2012/11/30/ PY - 2012/12/4/entrez PY - 2012/12/4/pubmed PY - 2013/2/16/medline SP - 3749 EP - 56 JF - Brain : a journal of neurology JO - Brain VL - 135 IS - Pt 12 N2 - A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer's disease. This study investigated the frequency and severity of atherosclerotic plaques in the circle of Willis in Alzheimer's disease and multiple other neurodegenerative diseases. Semi-quantitative data from gross and microscopic neuropathological examinations in 1000 cases were analysed, including 410 with a primary diagnosis of Alzheimer's disease, 230 with synucleinopathies, 157 with TDP-43 proteinopathies, 144 with tauopathies and 59 with normal ageing. More than 77% of subjects with Alzheimer's disease had grossly apparent circle of Willis atherosclerosis, a percentage that was significantly higher than normal (47%), or other neurodegenerative diseases (43-67%). Age- and sex-adjusted atherosclerosis ratings were highly correlated with neuritic plaque, paired helical filaments tau neurofibrillary tangle and cerebral amyloid angiopathy ratings in the whole sample and within individual groups. We found no associations between atherosclerosis ratings and α-synuclein or TDP-43 lesion ratings. The association between age-adjusted circle of Willis atherosclerosis and Alzheimer's disease-type pathology was more robust for female subjects than male subjects. These results provide further confirmation and specificity that vascular disease and Alzheimer's disease are interrelated and suggest that common aetiologic or reciprocally synergistic pathophysiological mechanisms promote both vascular pathology and plaque and tangle pathology. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/23204143/Cerebrovascular_atherosclerosis_correlates_with_Alzheimer_pathology_in_neurodegenerative_dementias_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/aws271 DB - PRIME DP - Unbound Medicine ER -