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Levonorgestrel-releasing intrauterine device is an efficacious contraceptive for women with leiomyoma.
J Int Med Res. 2012; 40(5):1966-72.JI

Abstract

OBJECTIVE

To evaluate the efficacy of a levonorgestrel-releasing intrauterine device (LNG-IUD) as contraception for women with uterine leiomyoma.

METHODS

Thirty women with uterine leiomyoma requiring contraception were enrolled and had a LNG-IUD inserted. Menstrual blood volume (assessed by a pictorial blood loss assessment chart [PBAC]), haemoglobin concentration, volume of uterus and leiomyoma were determined before and after LNG-IUD insertion.

RESULTS

The median (range) PBAC score was 145.0 (60.0-232.0) before LNG-IUD insertion, which significantly decreased to 44.0 (0.0-99.0) and 36.0 (0.0-90.0) after 6 and 12 months of LNG-IUD use, respectively. Prior to LNG-IUD insertion, the median haemoglobin concentration in patients with anaemia was 100.0 (69.0-109.0) g/l and this increased significantly after 6 and 12 months of LNG-IUD use, to 117.5 (101.0-131.0) g/l and 119.5 (108.0-135.0) g/l, respectively. There were no significant changes in uterine or leiomyoma volumes. No patient became pregnant and there were no severe side-effects; one IUD was expulsed.

CONCLUSION

The LNG-IUD may be a safe and effective contraceptive for women of reproductive age with uterine leiomyoma.

Links

Publisher Full Text
journals.sagepub.com
journals.sagepub.com

Authors+Show Affiliations

Xie ZW
Women's Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China.
Zhang YN
No affiliation info available
Wan S
No affiliation info available
Xu WZ
No affiliation info available
Chen J
No affiliation info available

MeSH

AdultContraceptive Agents, FemaleFemaleHumansIntrauterine Devices, MedicatedLeiomyomaLevonorgestrelMenorrhagiaMenstruationMiddle AgedUterine Neoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23206480

Citation

Xie, Z-W, et al. "Levonorgestrel-releasing Intrauterine Device Is an Efficacious Contraceptive for Women With Leiomyoma." The Journal of International Medical Research, vol. 40, no. 5, 2012, pp. 1966-72.
Xie ZW, Zhang YN, Wan S, et al. Levonorgestrel-releasing intrauterine device is an efficacious contraceptive for women with leiomyoma. J Int Med Res. 2012;40(5):1966-72.
Xie, Z. W., Zhang, Y. N., Wan, S., Xu, W. Z., & Chen, J. (2012). Levonorgestrel-releasing intrauterine device is an efficacious contraceptive for women with leiomyoma. The Journal of International Medical Research, 40(5), 1966-72.
Xie ZW, et al. Levonorgestrel-releasing Intrauterine Device Is an Efficacious Contraceptive for Women With Leiomyoma. J Int Med Res. 2012;40(5):1966-72. PubMed PMID: 23206480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levonorgestrel-releasing intrauterine device is an efficacious contraceptive for women with leiomyoma. AU - Xie,Z-W, AU - Zhang,Y-N, AU - Wan,S, AU - Xu,W-Z, AU - Chen,J, PY - 2012/12/5/entrez PY - 2012/12/5/pubmed PY - 2013/7/26/medline SP - 1966 EP - 72 JF - The Journal of international medical research JO - J Int Med Res VL - 40 IS - 5 N2 - OBJECTIVE: To evaluate the efficacy of a levonorgestrel-releasing intrauterine device (LNG-IUD) as contraception for women with uterine leiomyoma. METHODS: Thirty women with uterine leiomyoma requiring contraception were enrolled and had a LNG-IUD inserted. Menstrual blood volume (assessed by a pictorial blood loss assessment chart [PBAC]), haemoglobin concentration, volume of uterus and leiomyoma were determined before and after LNG-IUD insertion. RESULTS: The median (range) PBAC score was 145.0 (60.0-232.0) before LNG-IUD insertion, which significantly decreased to 44.0 (0.0-99.0) and 36.0 (0.0-90.0) after 6 and 12 months of LNG-IUD use, respectively. Prior to LNG-IUD insertion, the median haemoglobin concentration in patients with anaemia was 100.0 (69.0-109.0) g/l and this increased significantly after 6 and 12 months of LNG-IUD use, to 117.5 (101.0-131.0) g/l and 119.5 (108.0-135.0) g/l, respectively. There were no significant changes in uterine or leiomyoma volumes. No patient became pregnant and there were no severe side-effects; one IUD was expulsed. CONCLUSION: The LNG-IUD may be a safe and effective contraceptive for women of reproductive age with uterine leiomyoma. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/23206480/Levonorgestrel_releasing_intrauterine_device_is_an_efficacious_contraceptive_for_women_with_leiomyoma_ L2 - https://journals.sagepub.com/doi/10.1177/030006051204000538?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -