Tags

Type your tag names separated by a space and hit enter

[Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease].
Rev Neurol (Paris). 1990; 146(2):116-22.RN

Abstract

Apomorphine, a dopaminergic agonist was given over a period of 12 months to 14 parkinsonian patients suffering from severe L-dopa induced on-off effects. Nine patients (mean age: 52 years; mean age at onset of the disease: 37 years), were treated by continuous infusion with a portable minipump, and 5 others by multiple injections with a penject. The mean duration of daily off periods was reduced by two thirds in all patients. The motor fluctuation intensity was only diminished in the 9 patients treated by continuous infusion. These patients received a mean apomorphine daily dose of 93 mg and L-dopa dosage was reduced by 53 p. 100. Red fibrous subcutaneous nodules occurred at the injection sites in all patients treated by infusion. This study confirms the effectiveness of subcutaneous apomorphine administration in the treatment of severe motor fluctuations.

Authors+Show Affiliations

Département des Neurosciences Cliniques et Biologiques, Universitaire de Grenoble.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

2320817

Citation

Pollak, P, et al. "[Subcutaneous Administration of Apomorphine in Motor Fluctuations in Parkinson's Disease]." Revue Neurologique, vol. 146, no. 2, 1990, pp. 116-22.
Pollak P, Champay AS, Gaio JM, et al. [Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease]. Rev Neurol (Paris). 1990;146(2):116-22.
Pollak, P., Champay, A. S., Gaio, J. M., Hommel, M., Benabid, A. L., & Perret, J. (1990). [Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease]. Revue Neurologique, 146(2), 116-22.
Pollak P, et al. [Subcutaneous Administration of Apomorphine in Motor Fluctuations in Parkinson's Disease]. Rev Neurol (Paris). 1990;146(2):116-22. PubMed PMID: 2320817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease]. AU - Pollak,P, AU - Champay,A S, AU - Gaio,J M, AU - Hommel,M, AU - Benabid,A L, AU - Perret,J, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 116 EP - 22 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 146 IS - 2 N2 - Apomorphine, a dopaminergic agonist was given over a period of 12 months to 14 parkinsonian patients suffering from severe L-dopa induced on-off effects. Nine patients (mean age: 52 years; mean age at onset of the disease: 37 years), were treated by continuous infusion with a portable minipump, and 5 others by multiple injections with a penject. The mean duration of daily off periods was reduced by two thirds in all patients. The motor fluctuation intensity was only diminished in the 9 patients treated by continuous infusion. These patients received a mean apomorphine daily dose of 93 mg and L-dopa dosage was reduced by 53 p. 100. Red fibrous subcutaneous nodules occurred at the injection sites in all patients treated by infusion. This study confirms the effectiveness of subcutaneous apomorphine administration in the treatment of severe motor fluctuations. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/2320817/[Subcutaneous_administration_of_apomorphine_in_motor_fluctuations_in_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -