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Body size and risk of Hodgkin's lymphoma by age and gender: a population-based case-control study in Connecticut and Massachusetts.

Abstract

PURPOSE

Descriptive studies have indicated a rising trend in Hodgkin's lymphoma (HL) incidence in young adults, especially females. Increasing evidence has suggested that some risk factors associated with HL may vary by age or gender. Recent studies have reported an increased risk of HL associated with increasing body mass index (BMI), but the results have been inconsistent. The objectives of this study were to examine whether the associations between measures of body size (height, weight, and BMI) and HL risk vary by age and/or gender.

METHODS

A population-based case-control study was conducted in Connecticut and Massachusetts. A total of 567 HL cases and 679 controls were recruited in 1997-2000. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs).

RESULTS

Among younger women <35 years old, being overweight (25-29.9 kg/m(2)) versus normal weight (18.5-24.9 kg/m(2)) was significantly associated with an increased risk of HL (OR = 2.1, 95 % CI = 1.1-4.0). The risk increased with increasing weight and BMI (p trends <0.01). Among women ≥35 years old, by contrast, higher weight and BMI were associated with a reduced risk of HL (p trends <0.01). Conversely, there was no significant association between BMI and risk of HL in younger or older males.

CONCLUSIONS

These findings show that the associations between body size and risk of HL vary by gender and age, and require confirmation in other populations.

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  • Authors+Show Affiliations

    ,

    National Office of Cancer Prevention and Control, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China.

    , , , , , ,

    Source

    Cancer causes & control : CCC 24:2 2013 Feb pg 287-95

    MeSH

    Adolescent
    Adult
    Age Factors
    Aged
    Body Mass Index
    Case-Control Studies
    Connecticut
    Female
    Hodgkin Disease
    Humans
    Incidence
    Male
    Massachusetts
    Middle Aged
    Obesity
    Risk Factors
    Sex Factors
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    23208661

    Citation

    Li, Qian, et al. "Body Size and Risk of Hodgkin's Lymphoma By Age and Gender: a Population-based Case-control Study in Connecticut and Massachusetts." Cancer Causes & Control : CCC, vol. 24, no. 2, 2013, pp. 287-95.
    Li Q, Chang ET, Bassig BA, et al. Body size and risk of Hodgkin's lymphoma by age and gender: a population-based case-control study in Connecticut and Massachusetts. Cancer Causes Control. 2013;24(2):287-95.
    Li, Q., Chang, E. T., Bassig, B. A., Dai, M., Qin, Q., Gao, Y., ... Zheng, T. (2013). Body size and risk of Hodgkin's lymphoma by age and gender: a population-based case-control study in Connecticut and Massachusetts. Cancer Causes & Control : CCC, 24(2), pp. 287-95. doi:10.1007/s10552-012-0100-1.
    Li Q, et al. Body Size and Risk of Hodgkin's Lymphoma By Age and Gender: a Population-based Case-control Study in Connecticut and Massachusetts. Cancer Causes Control. 2013;24(2):287-95. PubMed PMID: 23208661.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body size and risk of Hodgkin's lymphoma by age and gender: a population-based case-control study in Connecticut and Massachusetts. AU - Li,Qian, AU - Chang,Ellen T, AU - Bassig,Bryan A, AU - Dai,Min, AU - Qin,Qin, AU - Gao,Yongshun, AU - Zhang,Yawei, AU - Zheng,Tongzhang, Y1 - 2012/12/04/ PY - 2012/07/25/received PY - 2012/11/07/accepted PY - 2012/12/5/entrez PY - 2012/12/5/pubmed PY - 2013/10/31/medline SP - 287 EP - 95 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 2 N2 - PURPOSE: Descriptive studies have indicated a rising trend in Hodgkin's lymphoma (HL) incidence in young adults, especially females. Increasing evidence has suggested that some risk factors associated with HL may vary by age or gender. Recent studies have reported an increased risk of HL associated with increasing body mass index (BMI), but the results have been inconsistent. The objectives of this study were to examine whether the associations between measures of body size (height, weight, and BMI) and HL risk vary by age and/or gender. METHODS: A population-based case-control study was conducted in Connecticut and Massachusetts. A total of 567 HL cases and 679 controls were recruited in 1997-2000. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs). RESULTS: Among younger women <35 years old, being overweight (25-29.9 kg/m(2)) versus normal weight (18.5-24.9 kg/m(2)) was significantly associated with an increased risk of HL (OR = 2.1, 95 % CI = 1.1-4.0). The risk increased with increasing weight and BMI (p trends <0.01). Among women ≥35 years old, by contrast, higher weight and BMI were associated with a reduced risk of HL (p trends <0.01). Conversely, there was no significant association between BMI and risk of HL in younger or older males. CONCLUSIONS: These findings show that the associations between body size and risk of HL vary by gender and age, and require confirmation in other populations. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23208661/Body_size_and_risk_of_Hodgkin's_lymphoma_by_age_and_gender:_a_population_based_case_control_study_in_Connecticut_and_Massachusetts_ L2 - https://doi.org/10.1007/s10552-012-0100-1 DB - PRIME DP - Unbound Medicine ER -