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The impact of influenza vaccinations on the adverse effects and hospitalization rate in the elderly: a national based study in an Asian country.

Abstract

OBJECTIVES

To examine the risk of adverse effects of special interest in persons vaccinated against seasonal influenza compared with unvaccinated persons aged 65 and above.

METHODS

We retrospectively observed 41,986 vaccinated elderly persons and 50,973 unvaccinated elderly persons in Taiwan from October 1, 2008, through September 30, 2009, using the National Health Insurance database. Neurological and autoimmune disorders and one-year hospitalization rates and in-hospital mortality rates were analyzed according to the vaccination status. Propensity score analysis was used to assess the relationship between adverse outcomes, hospitalization rates, and vaccination status.

RESULTS

45% of the elderly received influenza vaccination. Multiple logistic regression showed that the probability of being vaccinated was related to more patients visiting for URI symptoms (odds ratio (OR), 1.03; 95% CI, 1.02-1.03), men (OR, 1.15; 95% CI, 1.12-1.17), increased age (OR, 1.02; 95% CI, 1.02-1.03), and more comorbidities (OR, 1.2; 95% CI, 1.17-1.23). There were no statistical differences in neurological and autoimmune diseases between the vaccinated and unvaccinated individuals using propensity score analysis, but vaccinated persons had a reduced hospitalization rate of 19% (odds ratio [OR], 0.81; 95% CI, 0.77-0.84) for the first six-months and 13% for one-year of follow-up (OR, 0.87; 95% CI, 0.85-0.9).

CONCLUSIONS

Based on data from the one-year follow-ups among 93,049 elderly persons in Taiwan, reassuring results for selected neurological and autoimmune diseases were found among the vaccinated individuals after adjusting other factors. Influenza vaccination decreased the risk for hospitalization. Public health strategies must continue to improve the influenza vaccination rate among the elderly with information based upon tangible evidence.

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  • Authors+Show Affiliations

    ,

    Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.

    , , , , , , , , , ,

    Source

    PloS one 7:11 2012 pg e50337

    MeSH

    Aged
    Aged, 80 and over
    Autoimmune Diseases
    Communicable Disease Control
    Female
    Geriatrics
    Hospitalization
    Humans
    Infectious Disease Medicine
    Influenza Vaccines
    Influenza, Human
    Logistic Models
    Male
    Models, Statistical
    Nervous System Diseases
    Odds Ratio
    Retrospective Studies
    Risk
    Taiwan

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23209714

    Citation

    Ho, Tsung-Yu, et al. "The Impact of Influenza Vaccinations On the Adverse Effects and Hospitalization Rate in the Elderly: a National Based Study in an Asian Country." PloS One, vol. 7, no. 11, 2012, pp. e50337.
    Ho TY, Huang KY, Huang TT, et al. The impact of influenza vaccinations on the adverse effects and hospitalization rate in the elderly: a national based study in an Asian country. PLoS ONE. 2012;7(11):e50337.
    Ho, T. Y., Huang, K. Y., Huang, T. T., Huang, Y. S., Ho, H. C., Chou, P., ... Lee, C. C. (2012). The impact of influenza vaccinations on the adverse effects and hospitalization rate in the elderly: a national based study in an Asian country. PloS One, 7(11), pp. e50337. doi:10.1371/journal.pone.0050337.
    Ho TY, et al. The Impact of Influenza Vaccinations On the Adverse Effects and Hospitalization Rate in the Elderly: a National Based Study in an Asian Country. PLoS ONE. 2012;7(11):e50337. PubMed PMID: 23209714.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The impact of influenza vaccinations on the adverse effects and hospitalization rate in the elderly: a national based study in an Asian country. AU - Ho,Tsung-Yu, AU - Huang,Kuang-Yung, AU - Huang,Tza-Ta, AU - Huang,Yung-Sung, AU - Ho,Hsu-Chueh, AU - Chou,Pesus, AU - Lin,Chun-Hung, AU - Wei,Chang-Kao, AU - Lian,Wei-Chang, AU - Chen,Ting-Chang, AU - Huang,Hsien-Bin, AU - Lee,Ching-Chih, Y1 - 2012/11/28/ PY - 2012/06/24/received PY - 2012/10/18/accepted PY - 2012/12/5/entrez PY - 2012/12/5/pubmed PY - 2013/6/26/medline SP - e50337 EP - e50337 JF - PloS one JO - PLoS ONE VL - 7 IS - 11 N2 - OBJECTIVES: To examine the risk of adverse effects of special interest in persons vaccinated against seasonal influenza compared with unvaccinated persons aged 65 and above. METHODS: We retrospectively observed 41,986 vaccinated elderly persons and 50,973 unvaccinated elderly persons in Taiwan from October 1, 2008, through September 30, 2009, using the National Health Insurance database. Neurological and autoimmune disorders and one-year hospitalization rates and in-hospital mortality rates were analyzed according to the vaccination status. Propensity score analysis was used to assess the relationship between adverse outcomes, hospitalization rates, and vaccination status. RESULTS: 45% of the elderly received influenza vaccination. Multiple logistic regression showed that the probability of being vaccinated was related to more patients visiting for URI symptoms (odds ratio (OR), 1.03; 95% CI, 1.02-1.03), men (OR, 1.15; 95% CI, 1.12-1.17), increased age (OR, 1.02; 95% CI, 1.02-1.03), and more comorbidities (OR, 1.2; 95% CI, 1.17-1.23). There were no statistical differences in neurological and autoimmune diseases between the vaccinated and unvaccinated individuals using propensity score analysis, but vaccinated persons had a reduced hospitalization rate of 19% (odds ratio [OR], 0.81; 95% CI, 0.77-0.84) for the first six-months and 13% for one-year of follow-up (OR, 0.87; 95% CI, 0.85-0.9). CONCLUSIONS: Based on data from the one-year follow-ups among 93,049 elderly persons in Taiwan, reassuring results for selected neurological and autoimmune diseases were found among the vaccinated individuals after adjusting other factors. Influenza vaccination decreased the risk for hospitalization. Public health strategies must continue to improve the influenza vaccination rate among the elderly with information based upon tangible evidence. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23209714/The_impact_of_influenza_vaccinations_on_the_adverse_effects_and_hospitalization_rate_in_the_elderly:_a_national_based_study_in_an_Asian_country_ L2 - http://dx.plos.org/10.1371/journal.pone.0050337 DB - PRIME DP - Unbound Medicine ER -