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Treatment of postoperative nausea and vomiting after spinal anesthesia for cesarean delivery: A randomized, double-blinded comparison of midazolam, ondansetron, and a combination.
Adv Biomed Res. 2012; 1:2.AB

Abstract

BACKGROUND

The antiemetic efficacy of midazolam and ondansetron was shown before. The aim of the present study was to compare efficacy of using intravenous midazoalm, ondansetron, and midazolam in combination with ondansetron for treatment of nausea and vomiting after cesarean delivery in parturient underwent spinal anesthesia.

MATERIALS AND METHODS

ONE HUNDRED THIRTY TWO PARTURIENTS WERE RANDOMLY ALLOCATED TO ONE OF THREE GROUPS: group M (n = 44) that received intravenous midazoalm 30 μg/kg; group O (n = 44) that received intravenous ondansetron 8 mg; group MO (n = 44) that received intravenous midazoalm 30 μg/kg combined with intravenous ondansetron 8 mg if patients had vomiting or VAS of nausea ≥ 3 during surgery (after umbilical cord clamping) and 24 hours after that. The incidence and severity of vomiting episodes and nausea with visual analog scale (VAS) > 3 were evaluated at 2 hours, 6 hours, and 24 hours after injection of study drugs.

RESULTS

The incidence of nausea was significantly less in group MO compared with group M and group O at 6 hours postoperatively (P = 0.01). This variable was not significantly different in three groups at 2 hours and 24 hours after operation. The severity of nausea and vomiting was significantly different in three groups at 6 hours after operation (P < 0.05).

CONCLUSION

Our study showed that using intravenous midazolam 30 μg/kg in combination with intravenous ondansetron 8 mg was superior to administering single drug in treatment of emetic symptoms after cesarean delivery under spinal anesthesia.

Authors+Show Affiliations

Departments of Anesthesia, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23210061

Citation

Jabalameli, Mitra, et al. "Treatment of Postoperative Nausea and Vomiting After Spinal Anesthesia for Cesarean Delivery: a Randomized, Double-blinded Comparison of Midazolam, Ondansetron, and a Combination." Advanced Biomedical Research, vol. 1, 2012, p. 2.
Jabalameli M, Honarmand A, Safavi M, et al. Treatment of postoperative nausea and vomiting after spinal anesthesia for cesarean delivery: A randomized, double-blinded comparison of midazolam, ondansetron, and a combination. Advanced biomedical research. 2012;1:2.
Jabalameli, M., Honarmand, A., Safavi, M., & Chitsaz, M. (2012). Treatment of postoperative nausea and vomiting after spinal anesthesia for cesarean delivery: A randomized, double-blinded comparison of midazolam, ondansetron, and a combination. Advanced Biomedical Research, 1, 2. https://doi.org/10.4103/2277-9175.94424
Jabalameli M, et al. Treatment of Postoperative Nausea and Vomiting After Spinal Anesthesia for Cesarean Delivery: a Randomized, Double-blinded Comparison of Midazolam, Ondansetron, and a Combination. Advanced biomedical research. 2012;1:2. PubMed PMID: 23210061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of postoperative nausea and vomiting after spinal anesthesia for cesarean delivery: A randomized, double-blinded comparison of midazolam, ondansetron, and a combination. AU - Jabalameli,Mitra, AU - Honarmand,Azim, AU - Safavi,Mohammadreza, AU - Chitsaz,Mohsen, Y1 - 2012/03/28/ PY - 2011/12/09/received PY - 2012/01/01/accepted PY - 2012/12/5/entrez PY - 2012/12/5/pubmed PY - 2012/12/5/medline KW - Anesthesia KW - cesarean section KW - midazoalm KW - ondansetron KW - postoperative nausea and vomiting KW - spinal SP - 2 EP - 2 JF - Advanced biomedical research VL - 1 N2 - BACKGROUND: The antiemetic efficacy of midazolam and ondansetron was shown before. The aim of the present study was to compare efficacy of using intravenous midazoalm, ondansetron, and midazolam in combination with ondansetron for treatment of nausea and vomiting after cesarean delivery in parturient underwent spinal anesthesia. MATERIALS AND METHODS: ONE HUNDRED THIRTY TWO PARTURIENTS WERE RANDOMLY ALLOCATED TO ONE OF THREE GROUPS: group M (n = 44) that received intravenous midazoalm 30 μg/kg; group O (n = 44) that received intravenous ondansetron 8 mg; group MO (n = 44) that received intravenous midazoalm 30 μg/kg combined with intravenous ondansetron 8 mg if patients had vomiting or VAS of nausea ≥ 3 during surgery (after umbilical cord clamping) and 24 hours after that. The incidence and severity of vomiting episodes and nausea with visual analog scale (VAS) > 3 were evaluated at 2 hours, 6 hours, and 24 hours after injection of study drugs. RESULTS: The incidence of nausea was significantly less in group MO compared with group M and group O at 6 hours postoperatively (P = 0.01). This variable was not significantly different in three groups at 2 hours and 24 hours after operation. The severity of nausea and vomiting was significantly different in three groups at 6 hours after operation (P < 0.05). CONCLUSION: Our study showed that using intravenous midazolam 30 μg/kg in combination with intravenous ondansetron 8 mg was superior to administering single drug in treatment of emetic symptoms after cesarean delivery under spinal anesthesia. SN - 2277-9175 UR - https://www.unboundmedicine.com/medline/citation/23210061/Treatment_of_postoperative_nausea_and_vomiting_after_spinal_anesthesia_for_cesarean_delivery:_A_randomized_double_blinded_comparison_of_midazolam_ondansetron_and_a_combination_ L2 - http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=2;epage=2;aulast=Jabalameli DB - PRIME DP - Unbound Medicine ER -
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