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Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature.
Exp Hematol Oncol. 2012 Aug 13; 1(1):19.EH

Abstract

Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of bullous skin lesions is rare. Little is known about the mechanism of blister formation. These blisters are often hemorrhagic and typically occur in the oral mucosa. Only a few case reports have described skin involvement in systemic amyloidosis. The manifestation of bullous lesions on the breast in association with primary amyloidosis has not been previously reported. Therefore, we report a case of cutaneous hemorrhagic bullous of the breast secondary to primary systemic amyloidosis, which may be important for medical oncologists to be aware of this uncommon presentation of plasma cell dysrasias. Furthermore, this case only partially responded to the commonly used multiple myeloma-type regimen, the skin lesions responded completely to a five-drug combination chemotherapy regimen, utilizing immunomodulators, liposomal doxorubicin, cyclophosphamide, bortezomib, and dexamethasone, suggesting that a more aggressive modality of chemotherapy may be necessary to treat such cases.

Authors+Show Affiliations

Division of Hematology/Oncology, Brookdale University Hospital & Medical Center, Brooklyn, NY, 11212, USA. jcwang5@aol.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports

Language

eng

PubMed ID

23210921

Citation

Agheli, Aref, et al. "Response of Hemorrhagic Bullous Skin Lesions of the Breast Secondary to Primary Systemic Amyloidosis to a Five-drug Combination Chemotherapy: a Case Report and Review of the Literature." Experimental Hematology & Oncology, vol. 1, no. 1, 2012, p. 19.
Agheli A, Becker M, Becker G, et al. Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature. Exp Hematol Oncol. 2012;1(1):19.
Agheli, A., Becker, M., Becker, G., Chaudhry, M. R., & Wang, J. C. (2012). Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature. Experimental Hematology & Oncology, 1(1), 19. https://doi.org/10.1186/2162-3619-1-19
Agheli A, et al. Response of Hemorrhagic Bullous Skin Lesions of the Breast Secondary to Primary Systemic Amyloidosis to a Five-drug Combination Chemotherapy: a Case Report and Review of the Literature. Exp Hematol Oncol. 2012 Aug 13;1(1):19. PubMed PMID: 23210921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature. AU - Agheli,Aref, AU - Becker,Marvin, AU - Becker,Gary, AU - Chaudhry,M Rashid, AU - Wang,Jen C, Y1 - 2012/08/13/ PY - 2012/05/04/received PY - 2012/05/30/accepted PY - 2012/12/6/entrez PY - 2012/12/6/pubmed PY - 2012/12/6/medline SP - 19 EP - 19 JF - Experimental hematology & oncology JO - Exp Hematol Oncol VL - 1 IS - 1 N2 - Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of bullous skin lesions is rare. Little is known about the mechanism of blister formation. These blisters are often hemorrhagic and typically occur in the oral mucosa. Only a few case reports have described skin involvement in systemic amyloidosis. The manifestation of bullous lesions on the breast in association with primary amyloidosis has not been previously reported. Therefore, we report a case of cutaneous hemorrhagic bullous of the breast secondary to primary systemic amyloidosis, which may be important for medical oncologists to be aware of this uncommon presentation of plasma cell dysrasias. Furthermore, this case only partially responded to the commonly used multiple myeloma-type regimen, the skin lesions responded completely to a five-drug combination chemotherapy regimen, utilizing immunomodulators, liposomal doxorubicin, cyclophosphamide, bortezomib, and dexamethasone, suggesting that a more aggressive modality of chemotherapy may be necessary to treat such cases. SN - 2162-3619 UR - https://www.unboundmedicine.com/medline/citation/23210921/Response_of_hemorrhagic_bullous_skin_lesions_of_the_breast_secondary_to_primary_systemic_amyloidosis_to_a_five_drug_combination_chemotherapy:_a_case_report_and_review_of_the_literature_ L2 - https://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-1-19 DB - PRIME DP - Unbound Medicine ER -
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