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The influence of cognitive reserve on cognition in Parkinson's disease.
J Neural Transm (Vienna) 2013; 120(4):593-6JN

Abstract

There are considerable differences in cognition between individuals with Parkinson's Disease (PD) which might be explained by the theory of cognitive reserve. This theory states that premorbid factors, such as high intellectual capacities, provide a buffer against cognitive impairments. This study determines whether cognitive reserve influences cognition in PD. Forty-eight PD patients were included. All were assessed with two proxies of cognitive reserve, tests of cognition and both measures of disease characteristic and symptoms of depression. After accounting for age, gender, disease characteristics and depression, cognitive reserve was an independent predictor of cognitive performance. In conclusion, cognitive reserve influences cognition in PD, i.e. PD patients with a high premorbid intellectual ability show fewer cognitive impairments than patients with a low premorbid ability. This indicates that cognitive reserve needs to be taken into account when monitoring the evolution of cognition in PD, however, verification of results on a larger patient sample would be desirable.

Authors+Show Affiliations

Department of Clinical and Developmental Neuropsychology, Faculty of Behavioral and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, 9712 TS, Groningen, The Netherlands. janneke.koerts@rug.nl

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23212723

Citation

Koerts, Janneke, et al. "The Influence of Cognitive Reserve On Cognition in Parkinson's Disease." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 120, no. 4, 2013, pp. 593-6.
Koerts J, Tucha L, Lange KW, et al. The influence of cognitive reserve on cognition in Parkinson's disease. J Neural Transm (Vienna). 2013;120(4):593-6.
Koerts, J., Tucha, L., Lange, K. W., & Tucha, O. (2013). The influence of cognitive reserve on cognition in Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996), 120(4), pp. 593-6. doi:10.1007/s00702-012-0916-6.
Koerts J, et al. The Influence of Cognitive Reserve On Cognition in Parkinson's Disease. J Neural Transm (Vienna). 2013;120(4):593-6. PubMed PMID: 23212723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of cognitive reserve on cognition in Parkinson's disease. AU - Koerts,Janneke, AU - Tucha,Lara, AU - Lange,Klaus W, AU - Tucha,Oliver, Y1 - 2012/12/02/ PY - 2012/09/29/received PY - 2012/11/07/accepted PY - 2012/12/6/entrez PY - 2012/12/6/pubmed PY - 2013/10/26/medline SP - 593 EP - 6 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 120 IS - 4 N2 - There are considerable differences in cognition between individuals with Parkinson's Disease (PD) which might be explained by the theory of cognitive reserve. This theory states that premorbid factors, such as high intellectual capacities, provide a buffer against cognitive impairments. This study determines whether cognitive reserve influences cognition in PD. Forty-eight PD patients were included. All were assessed with two proxies of cognitive reserve, tests of cognition and both measures of disease characteristic and symptoms of depression. After accounting for age, gender, disease characteristics and depression, cognitive reserve was an independent predictor of cognitive performance. In conclusion, cognitive reserve influences cognition in PD, i.e. PD patients with a high premorbid intellectual ability show fewer cognitive impairments than patients with a low premorbid ability. This indicates that cognitive reserve needs to be taken into account when monitoring the evolution of cognition in PD, however, verification of results on a larger patient sample would be desirable. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/23212723/The_influence_of_cognitive_reserve_on_cognition_in_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s00702-012-0916-6 DB - PRIME DP - Unbound Medicine ER -