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[Subclinical thyroid disease].
Nihon Rinsho. 2012 Nov; 70(11):1865-71.NR

Abstract

Subclinical thyroid disease is defined as a disorder involving an abnormal serum thyroid-stimulating hormone level (TSH), but free thyroxine (FT4) and triiodothyronine (FT3) levels within the reference range. The prevalence of subclinical hypothyroidism is about 4 to 8.5 percent of the population, and may rise to about 20 percent in women older than 60 years. The clinical significance of subclinical thyroid disease remains controversial. Several studies have reported that subclinical hypothyroidism may be a risk factor for atherosclerosis and cardiovascular disorders, and subclinical hyperthyroidism for atrial fibrillation and reduced bone mineral density. However, there is a little evidence showing the significance of early treatment for both disorders. In this review, we discuss the prevalence, diagnosis, natural history, and potential pathophysiological consequences of subclinical hypo- and hyperthyroidism.

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Authors+Show Affiliations

Nakajima Y
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine.
Yamada M
No affiliation info available

MeSH

Cardiovascular DiseasesHumansHyperthyroidismHypothyroidismPrevalenceRisk FactorsThyroxine

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

23214054

Citation

Nakajima, Yasuyo, and Masanobu Yamada. "[Subclinical Thyroid Disease]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 70, no. 11, 2012, pp. 1865-71.
Nakajima Y, Yamada M. [Subclinical thyroid disease]. Nihon Rinsho. 2012;70(11):1865-71.
Nakajima, Y., & Yamada, M. (2012). [Subclinical thyroid disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 70(11), 1865-71.
Nakajima Y, Yamada M. [Subclinical Thyroid Disease]. Nihon Rinsho. 2012;70(11):1865-71. PubMed PMID: 23214054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Subclinical thyroid disease]. AU - Nakajima,Yasuyo, AU - Yamada,Masanobu, PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/4/5/medline SP - 1865 EP - 71 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nihon Rinsho VL - 70 IS - 11 N2 - Subclinical thyroid disease is defined as a disorder involving an abnormal serum thyroid-stimulating hormone level (TSH), but free thyroxine (FT4) and triiodothyronine (FT3) levels within the reference range. The prevalence of subclinical hypothyroidism is about 4 to 8.5 percent of the population, and may rise to about 20 percent in women older than 60 years. The clinical significance of subclinical thyroid disease remains controversial. Several studies have reported that subclinical hypothyroidism may be a risk factor for atherosclerosis and cardiovascular disorders, and subclinical hyperthyroidism for atrial fibrillation and reduced bone mineral density. However, there is a little evidence showing the significance of early treatment for both disorders. In this review, we discuss the prevalence, diagnosis, natural history, and potential pathophysiological consequences of subclinical hypo- and hyperthyroidism. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/23214054/[Subclinical_thyroid_disease]_ L2 - https://www.medicalonline.jp/meteo_linkout.php?issn=0047-1852&volume=70&issue=11&spage=1865 DB - PRIME DP - Unbound Medicine ER -