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Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women.
Am J Clin Nutr. 1990 Apr; 51(4):649-55.AJ

Abstract

The effect of ascorbic acid on iron retention from a diet with predicted low iron bioavailability (containing minimal meat and ascorbic acid) was investigated in iron-depleted premenopausal women. Eleven women were depleted of storage iron (indicated by serum ferritin) through a combination of diet (5.0 mg Fe/2000 kcal for 67-88 d) and phlebotomy. They then consumed a diet containing 13.7 mg Fe/2000 kcal, supplemented with placebo or ascorbic acid three times daily (1500 mg total) with meals for 5.5 wk. Ascorbic acid improved apparent iron absorption (balance method) [38 +/- 2% (means +/- SEM) vs 27 +/- 2%]. Ascorbic acid also improved hemoglobin, erythrocyte protoporphyrins, and serum iron but not hematocrit, serum ferritin, iron-binding capacity, or transferrin saturation. In iron-depleted women consuming a diet with predicted poor iron availability, ascorbic acid supplementation enhanced body iron retention for 5.5 wk.

Authors+Show Affiliations

US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, ND.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2321571

Citation

Hunt, J R., et al. "Ascorbic Acid: Effect On Ongoing Iron Absorption and Status in Iron-depleted Young Women." The American Journal of Clinical Nutrition, vol. 51, no. 4, 1990, pp. 649-55.
Hunt JR, Mullen LM, Lykken GI, et al. Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am J Clin Nutr. 1990;51(4):649-55.
Hunt, J. R., Mullen, L. M., Lykken, G. I., Gallagher, S. K., & Nielsen, F. H. (1990). Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. The American Journal of Clinical Nutrition, 51(4), 649-55.
Hunt JR, et al. Ascorbic Acid: Effect On Ongoing Iron Absorption and Status in Iron-depleted Young Women. Am J Clin Nutr. 1990;51(4):649-55. PubMed PMID: 2321571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. AU - Hunt,J R, AU - Mullen,L M, AU - Lykken,G I, AU - Gallagher,S K, AU - Nielsen,F H, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 649 EP - 55 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 51 IS - 4 N2 - The effect of ascorbic acid on iron retention from a diet with predicted low iron bioavailability (containing minimal meat and ascorbic acid) was investigated in iron-depleted premenopausal women. Eleven women were depleted of storage iron (indicated by serum ferritin) through a combination of diet (5.0 mg Fe/2000 kcal for 67-88 d) and phlebotomy. They then consumed a diet containing 13.7 mg Fe/2000 kcal, supplemented with placebo or ascorbic acid three times daily (1500 mg total) with meals for 5.5 wk. Ascorbic acid improved apparent iron absorption (balance method) [38 +/- 2% (means +/- SEM) vs 27 +/- 2%]. Ascorbic acid also improved hemoglobin, erythrocyte protoporphyrins, and serum iron but not hematocrit, serum ferritin, iron-binding capacity, or transferrin saturation. In iron-depleted women consuming a diet with predicted poor iron availability, ascorbic acid supplementation enhanced body iron retention for 5.5 wk. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/2321571/Ascorbic_acid:_effect_on_ongoing_iron_absorption_and_status_in_iron_depleted_young_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/51.4.649 DB - PRIME DP - Unbound Medicine ER -