Tags

Type your tag names separated by a space and hit enter

Acute systemic and lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies.
Inhal Toxicol. 2012 Dec; 24(14):952-65.IT

Abstract

Inflammation is regarded as an important mechanism behind mortality and morbidity experienced by cardiorespiratory patients exposed to urban air particulate matter (PM). Small-scale biomass combustion is an important source of particulate air pollution. In this study, we investigated association between inflammatory responses and chemical composition of PM(1) emissions from seven different small-scale wood combustion appliances representing old and modern technologies. Healthy C57Bl/6J mice were exposed by intratracheal aspiration to single dose (10 mg/kg) of particulate samples. At 4 and 18 h after the exposure, bronchoalveolar lavage fluid (BALF) as well as serum was collected for subsequent analyses of inflammatory indicators (interleukin (IL)-6, IL-1β, IL-12, and IL-10; tumor necrosis factor-α (TNF-α); keratinocyte-derived chemoattractant (KC), and interferon-γ (IFN-γ)) in multiplexing assay. When the responses to the PM(1) samples were compared on an equal mass basis, the PM from modern technology appliances increased IL-6, KC, and IL-1β levels significantly in BALF at 4 and 18 h after the exposure. In contrast, these responses were seen only at 4 h time point in serum. Increased cytokine concentrations correlated with metal-rich ash related compounds which were more predominant in the modern technology furnaces emissions. These particles induced both local and systemic inflammation. Instead, polycyclic hydrocarbon (PAH) rich PM(1) samples from old technology (OT) evoked only minor inflammatory responses. In conclusion, the combustion technology largely affects the toxicological and chemical characteristics of the emissions. The large mass emissions of old combustion technology should be considered, when evaluating the overall harmfulness between the appliances. However, even the small emissions from modern technologies may pose significant toxic risks.

Authors+Show Affiliations

Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland. oskari.uski@uef.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23216156

Citation

Uski, Oskari J., et al. "Acute Systemic and Lung Inflammation in C57Bl/6J Mice After Intratracheal Aspiration of Particulate Matter From Small-scale Biomass Combustion Appliances Based On Old and Modern Technologies." Inhalation Toxicology, vol. 24, no. 14, 2012, pp. 952-65.
Uski OJ, Happo MS, Jalava PI, et al. Acute systemic and lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies. Inhal Toxicol. 2012;24(14):952-65.
Uski, O. J., Happo, M. S., Jalava, P. I., Brunner, T., Kelz, J., Obernberger, I., Jokiniemi, J., & Hirvonen, M. R. (2012). Acute systemic and lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies. Inhalation Toxicology, 24(14), 952-65. https://doi.org/10.3109/08958378.2012.742172
Uski OJ, et al. Acute Systemic and Lung Inflammation in C57Bl/6J Mice After Intratracheal Aspiration of Particulate Matter From Small-scale Biomass Combustion Appliances Based On Old and Modern Technologies. Inhal Toxicol. 2012;24(14):952-65. PubMed PMID: 23216156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute systemic and lung inflammation in C57Bl/6J mice after intratracheal aspiration of particulate matter from small-scale biomass combustion appliances based on old and modern technologies. AU - Uski,Oskari J, AU - Happo,Mikko S, AU - Jalava,Pasi I, AU - Brunner,Thomas, AU - Kelz,Joachim, AU - Obernberger,Ingwald, AU - Jokiniemi,Jorma, AU - Hirvonen,Maija-Riitta, PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/5/23/medline SP - 952 EP - 65 JF - Inhalation toxicology JO - Inhal Toxicol VL - 24 IS - 14 N2 - Inflammation is regarded as an important mechanism behind mortality and morbidity experienced by cardiorespiratory patients exposed to urban air particulate matter (PM). Small-scale biomass combustion is an important source of particulate air pollution. In this study, we investigated association between inflammatory responses and chemical composition of PM(1) emissions from seven different small-scale wood combustion appliances representing old and modern technologies. Healthy C57Bl/6J mice were exposed by intratracheal aspiration to single dose (10 mg/kg) of particulate samples. At 4 and 18 h after the exposure, bronchoalveolar lavage fluid (BALF) as well as serum was collected for subsequent analyses of inflammatory indicators (interleukin (IL)-6, IL-1β, IL-12, and IL-10; tumor necrosis factor-α (TNF-α); keratinocyte-derived chemoattractant (KC), and interferon-γ (IFN-γ)) in multiplexing assay. When the responses to the PM(1) samples were compared on an equal mass basis, the PM from modern technology appliances increased IL-6, KC, and IL-1β levels significantly in BALF at 4 and 18 h after the exposure. In contrast, these responses were seen only at 4 h time point in serum. Increased cytokine concentrations correlated with metal-rich ash related compounds which were more predominant in the modern technology furnaces emissions. These particles induced both local and systemic inflammation. Instead, polycyclic hydrocarbon (PAH) rich PM(1) samples from old technology (OT) evoked only minor inflammatory responses. In conclusion, the combustion technology largely affects the toxicological and chemical characteristics of the emissions. The large mass emissions of old combustion technology should be considered, when evaluating the overall harmfulness between the appliances. However, even the small emissions from modern technologies may pose significant toxic risks. SN - 1091-7691 UR - https://www.unboundmedicine.com/medline/citation/23216156/Acute_systemic_and_lung_inflammation_in_C57Bl/6J_mice_after_intratracheal_aspiration_of_particulate_matter_from_small_scale_biomass_combustion_appliances_based_on_old_and_modern_technologies_ L2 - https://www.tandfonline.com/doi/full/10.3109/08958378.2012.742172 DB - PRIME DP - Unbound Medicine ER -