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Percutaneous collagen induction: an effective and safe treatment for post-acne scarring in different skin phototypes.
J Dermatolog Treat. 2014 Apr; 25(2):147-52.JD

Abstract

BACKGROUND

Atrophic scars can complicate moderate and severe acne. There are, at present, several modalities of treatment with different results. Percutaneous collagen induction (PCI) has recently been proposed as a simple and effective therapeutic option for the management of atrophic scars.

OBJECTIVE

The aim of our study was to analyze the efficacy and safety of percutaneous collagen induction for the treatment of acne scarring in different skin phototypes.

METHODS & MATERIALS

A total of 60 patients of skin types phototype I to VI were included in the study. They were divided into three groups before beginning treatment: Group A (phototypes I to II), Group B (phototypes III to V), and Group C (phototypes VI). Each patient had three treatments at monthly intervals. The aesthetic improvement was evaluated by using a Global Aesthetic Improvement Scale (GAIS), and analyzed statistically by computerized image analysis of the patients' photographs. The differences in the GAIS scores in the different time-points of each group were found using the Wilcoxon's test for nonparametric-dependent continuous variables. Computerized image analysis of silicone replicas was used to quantify the irregularity of the surface micro-relief with Fast Fourier Transformation (FFT); average values of gray were obtained along the x- and y-axes. The calculated indexes were the integrals of areas arising from the distribution of pixels along the axes.

RESULTS

All patients completed the study. The Wilcoxon's test for nonparametric-dependent continuous variables showed a statistically significant (p < 0.05) reduction in severity grade of acne scars at T5 compared to baseline (T1). The analysis of the surface micro-relief performed on skin replicas showed a decrease in the degree of irregularity of skin texture in all three groups of patients, with an average reduction of 31% in both axes after three sessions. No short- or long-term dyschromia was observed.

CONCLUSION

PCI offers a simple and safe modality to improve the appearance of acne scars without risk of dyspigmentation in patient of all skin types.

Authors+Show Affiliations

Department of Systematic Pathology, Division of Dermatology, University of Naples Federico II , Naples , Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23216209

Citation

Fabbrocini, Gabriella, et al. "Percutaneous Collagen Induction: an Effective and Safe Treatment for Post-acne Scarring in Different Skin Phototypes." The Journal of Dermatological Treatment, vol. 25, no. 2, 2014, pp. 147-52.
Fabbrocini G, De Vita V, Monfrecola A, et al. Percutaneous collagen induction: an effective and safe treatment for post-acne scarring in different skin phototypes. J Dermatolog Treat. 2014;25(2):147-52.
Fabbrocini, G., De Vita, V., Monfrecola, A., De Padova, M. P., Brazzini, B., Teixeira, F., & Chu, A. (2014). Percutaneous collagen induction: an effective and safe treatment for post-acne scarring in different skin phototypes. The Journal of Dermatological Treatment, 25(2), 147-52. https://doi.org/10.3109/09546634.2012.742949
Fabbrocini G, et al. Percutaneous Collagen Induction: an Effective and Safe Treatment for Post-acne Scarring in Different Skin Phototypes. J Dermatolog Treat. 2014;25(2):147-52. PubMed PMID: 23216209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Percutaneous collagen induction: an effective and safe treatment for post-acne scarring in different skin phototypes. AU - Fabbrocini,Gabriella, AU - De Vita,Valerio, AU - Monfrecola,Ambra, AU - De Padova,Maria Pia, AU - Brazzini,Benedetta, AU - Teixeira,Fernanda, AU - Chu,Anthony, Y1 - 2012/12/08/ PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2014/4/9/medline SP - 147 EP - 52 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 25 IS - 2 N2 - BACKGROUND: Atrophic scars can complicate moderate and severe acne. There are, at present, several modalities of treatment with different results. Percutaneous collagen induction (PCI) has recently been proposed as a simple and effective therapeutic option for the management of atrophic scars. OBJECTIVE: The aim of our study was to analyze the efficacy and safety of percutaneous collagen induction for the treatment of acne scarring in different skin phototypes. METHODS & MATERIALS: A total of 60 patients of skin types phototype I to VI were included in the study. They were divided into three groups before beginning treatment: Group A (phototypes I to II), Group B (phototypes III to V), and Group C (phototypes VI). Each patient had three treatments at monthly intervals. The aesthetic improvement was evaluated by using a Global Aesthetic Improvement Scale (GAIS), and analyzed statistically by computerized image analysis of the patients' photographs. The differences in the GAIS scores in the different time-points of each group were found using the Wilcoxon's test for nonparametric-dependent continuous variables. Computerized image analysis of silicone replicas was used to quantify the irregularity of the surface micro-relief with Fast Fourier Transformation (FFT); average values of gray were obtained along the x- and y-axes. The calculated indexes were the integrals of areas arising from the distribution of pixels along the axes. RESULTS: All patients completed the study. The Wilcoxon's test for nonparametric-dependent continuous variables showed a statistically significant (p < 0.05) reduction in severity grade of acne scars at T5 compared to baseline (T1). The analysis of the surface micro-relief performed on skin replicas showed a decrease in the degree of irregularity of skin texture in all three groups of patients, with an average reduction of 31% in both axes after three sessions. No short- or long-term dyschromia was observed. CONCLUSION: PCI offers a simple and safe modality to improve the appearance of acne scars without risk of dyspigmentation in patient of all skin types. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/23216209/Percutaneous_collagen_induction:_an_effective_and_safe_treatment_for_post-acne_scarring_in_different_skin_phototypes. DB - PRIME DP - Unbound Medicine ER -