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Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer.
World J Surg Oncol. 2012 Dec 08; 10:262.WJ

Abstract

BACKGROUND

Breast ductal cancer in situ (DCIS) can recur or progress to invasive ductal cancer (IDC), and the interim stage include DCIS with microinvasion (DCIS-Mi). In this article, we attempt to study the study the differences of clinicopathological features, imaging data, and immunohistochemical-based subtypes among DCIS, DCIS-Mi, and IDC.

METHODS

In this retrospective study, we attempt to compare the clinicopathological features, immunohistochemical results and imaging data of 866 patients (included 73 DCIS, 72 DCIS-Mi, and 721 IDC).

RESULTS

Patients with DCIS and DCIS-Mi were younger than those with IDC (P = 0.007). DCIS and DCIS-Mi often happened in premenopausal women while IDC was opposite (P <0.001). The incidence of IDC with node-positive was significantly higher than it in DCIS and DCIS-Mi (P <0.001). We also observed that the Her2-positive was more often found in patients with pure DCIS compared to those with DCIS-Mi and DCIS-I (P <0.001). There was a significant difference between the four subgroups (Luminal-A, Luminal-B, ERBB2+, Basal-like) from DCIS, DCIS-Mi, and IDC (P <0.001). Basal-like patients were fewer than other subgroups in DCIS, DCIS-Mi, and IDC. The incidence of the first performance of ultrasound (catheter winded and nodular mass) and mammography (nodular mass) had significantly difference among patients with DCIS, DCIS-Mi, and IDC (P <0.001).

CONCLUSIONS

Different clinicopathological, immunohistochemical, and imaging features among DCIS, DCIS-Mi, and IDC indicate that they are distinct entities. A larger sample size is needed for further study.

Authors+Show Affiliations

Department of Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23216911

Citation

Zhang, Wei, et al. "Different Distribution of Breast Ductal Carcinoma in Situ, Ductal Carcinoma in Situ With Microinvasion, and Invasion Breast Cancer." World Journal of Surgical Oncology, vol. 10, 2012, p. 262.
Zhang W, Gao EL, Zhou YL, et al. Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer. World J Surg Oncol. 2012;10:262.
Zhang, W., Gao, E. L., Zhou, Y. L., Zhai, Q., Zou, Z. Y., Guo, G. L., Chen, G. R., Zheng, H. M., Huang, G. L., & Zhang, X. H. (2012). Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer. World Journal of Surgical Oncology, 10, 262. https://doi.org/10.1186/1477-7819-10-262
Zhang W, et al. Different Distribution of Breast Ductal Carcinoma in Situ, Ductal Carcinoma in Situ With Microinvasion, and Invasion Breast Cancer. World J Surg Oncol. 2012 Dec 8;10:262. PubMed PMID: 23216911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer. AU - Zhang,Wei, AU - Gao,Er-li, AU - Zhou,Yi-li, AU - Zhai,Qi, AU - Zou,Zhang-yong, AU - Guo,Gui-long, AU - Chen,Guo-rong, AU - Zheng,Hua-min, AU - Huang,Guan-li, AU - Zhang,Xiao-hua, Y1 - 2012/12/08/ PY - 2012/09/08/received PY - 2012/11/24/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/6/19/medline SP - 262 EP - 262 JF - World journal of surgical oncology JO - World J Surg Oncol VL - 10 N2 - BACKGROUND: Breast ductal cancer in situ (DCIS) can recur or progress to invasive ductal cancer (IDC), and the interim stage include DCIS with microinvasion (DCIS-Mi). In this article, we attempt to study the study the differences of clinicopathological features, imaging data, and immunohistochemical-based subtypes among DCIS, DCIS-Mi, and IDC. METHODS: In this retrospective study, we attempt to compare the clinicopathological features, immunohistochemical results and imaging data of 866 patients (included 73 DCIS, 72 DCIS-Mi, and 721 IDC). RESULTS: Patients with DCIS and DCIS-Mi were younger than those with IDC (P = 0.007). DCIS and DCIS-Mi often happened in premenopausal women while IDC was opposite (P <0.001). The incidence of IDC with node-positive was significantly higher than it in DCIS and DCIS-Mi (P <0.001). We also observed that the Her2-positive was more often found in patients with pure DCIS compared to those with DCIS-Mi and DCIS-I (P <0.001). There was a significant difference between the four subgroups (Luminal-A, Luminal-B, ERBB2+, Basal-like) from DCIS, DCIS-Mi, and IDC (P <0.001). Basal-like patients were fewer than other subgroups in DCIS, DCIS-Mi, and IDC. The incidence of the first performance of ultrasound (catheter winded and nodular mass) and mammography (nodular mass) had significantly difference among patients with DCIS, DCIS-Mi, and IDC (P <0.001). CONCLUSIONS: Different clinicopathological, immunohistochemical, and imaging features among DCIS, DCIS-Mi, and IDC indicate that they are distinct entities. A larger sample size is needed for further study. SN - 1477-7819 UR - https://www.unboundmedicine.com/medline/citation/23216911/Different_distribution_of_breast_ductal_carcinoma_in_situ_ductal_carcinoma_in_situ_with_microinvasion_and_invasion_breast_cancer_ L2 - https://wjso.biomedcentral.com/articles/10.1186/1477-7819-10-262 DB - PRIME DP - Unbound Medicine ER -