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Sesquiterpenoid derivatives from Ferula ferulaeoides (Steud.) Korov.
Phytochemistry. 2013 Feb; 86:151-8.P

Abstract

Eight sesquiterpenoids, named Ferulaeone A-H (1-8), and seven known sesquiterpenoid derivatives were isolated from the roots of Ferula ferulaeoides (Steud.) Korov. Their structures were established by comprehensive spectroscopic analysis, and biosynthetic pathways leading to these compounds were proposed. The cytotoxicity of all these isolates against HepG2, MCF-7, and C6 cancer cell lines was evaluated and compounds 6-11, 13 exihibited various degrees of cytotoxic effect. Among them, compounds 9-11 displayed the highest potency against C6 with IC(50) values 34, 36, and 31 μM, respectively.

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Authors+Show Affiliations

Meng H
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Li G
No affiliation info available
Huang J
No affiliation info available
Zhang K
No affiliation info available
Wei X
No affiliation info available
Ma Y
No affiliation info available
Zhang C
No affiliation info available
Wang J
No affiliation info available

MeSH

ApiaceaeCell LineCell SurvivalFerulaHep G2 CellsHumansMagnetic Resonance SpectroscopyMolecular StructureSesquiterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23218017

Citation

Meng, He, et al. "Sesquiterpenoid Derivatives From Ferula Ferulaeoides (Steud.) Korov." Phytochemistry, vol. 86, 2013, pp. 151-8.
Meng H, Li G, Huang J, et al. Sesquiterpenoid derivatives from Ferula ferulaeoides (Steud.) Korov. Phytochemistry. 2013;86:151-8.
Meng, H., Li, G., Huang, J., Zhang, K., Wei, X., Ma, Y., Zhang, C., & Wang, J. (2013). Sesquiterpenoid derivatives from Ferula ferulaeoides (Steud.) Korov. Phytochemistry, 86, 151-8. https://doi.org/10.1016/j.phytochem.2012.10.013
Meng H, et al. Sesquiterpenoid Derivatives From Ferula Ferulaeoides (Steud.) Korov. Phytochemistry. 2013;86:151-8. PubMed PMID: 23218017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpenoid derivatives from Ferula ferulaeoides (Steud.) Korov. AU - Meng,He, AU - Li,Guoyu, AU - Huang,Jian, AU - Zhang,Ke, AU - Wei,Xiuyan, AU - Ma,Yueping, AU - Zhang,Cui, AU - Wang,Jinhui, Y1 - 2012/12/03/ PY - 2012/01/18/received PY - 2012/07/20/revised PY - 2012/10/16/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/6/1/medline SP - 151 EP - 8 JF - Phytochemistry JO - Phytochemistry VL - 86 N2 - Eight sesquiterpenoids, named Ferulaeone A-H (1-8), and seven known sesquiterpenoid derivatives were isolated from the roots of Ferula ferulaeoides (Steud.) Korov. Their structures were established by comprehensive spectroscopic analysis, and biosynthetic pathways leading to these compounds were proposed. The cytotoxicity of all these isolates against HepG2, MCF-7, and C6 cancer cell lines was evaluated and compounds 6-11, 13 exihibited various degrees of cytotoxic effect. Among them, compounds 9-11 displayed the highest potency against C6 with IC(50) values 34, 36, and 31 μM, respectively. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/23218017/Sesquiterpenoid_derivatives_from_Ferula_ferulaeoides__Steud___Korov_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(12)00469-4 DB - PRIME DP - Unbound Medicine ER -