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Association between inflammatory biomarker serum procalcitonin and obesity in women with polycystic ovary syndrome.
J Reprod Immunol. 2013 Apr; 97(2):232-9.JR

Abstract

Procalcitonin (PCT) is a potential biomarker of obesity-related, low-grade inflammation in polycystic ovary syndrome (PCOS). We aimed to investigate whether serum procalcitonin, high-sensitivity C-reactive protein (hs-CRP), white blood cell (WBC) and neutrophil counts are associated with polycystic ovary syndrome and with obesity. A case-control study included 107 women with PCOS and 93 healthy controls, they were then stratified according to their body mass index (BMI) into three subgroups; lean, overweight and obese. Serum PCT levels were measured using enzyme linked immunosorbent assay. PCOS patients had significantly higher levels of serum PCT, hs-CRP, WBC, and neutrophil counts than healthy women. In control and PCOS groups, serum PCT, hs-CRP levels, WBC, and neutrophil counts were significantly increased in overweight and obese women compared with lean subjects. Serum PCT levels were positively correlated with BMI, waist/hip ratio, total cholesterol, serum triglycerides, LH/FSH, hs-CRP values, WBC and neutrophil counts in PCOS women. We also observed that the increasing obesity was accompanied by a significant increase in the mean values of serum PCT and neutrophil counts in PCOS patients. We conclude that serum PCT is a novel biomarker for low-grade chronic inflammation in PCOS patients, especially in obese women. Thus, PCT is a promising useful marker for accurate diagnosis of the inflammatory activity of body fat and of PCOS.

Authors+Show Affiliations

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23218400

Citation

Rashad, Nearmeen M., et al. "Association Between Inflammatory Biomarker Serum Procalcitonin and Obesity in Women With Polycystic Ovary Syndrome." Journal of Reproductive Immunology, vol. 97, no. 2, 2013, pp. 232-9.
Rashad NM, El-Shal AS, Abdelaziz AM. Association between inflammatory biomarker serum procalcitonin and obesity in women with polycystic ovary syndrome. J Reprod Immunol. 2013;97(2):232-9.
Rashad, N. M., El-Shal, A. S., & Abdelaziz, A. M. (2013). Association between inflammatory biomarker serum procalcitonin and obesity in women with polycystic ovary syndrome. Journal of Reproductive Immunology, 97(2), 232-9. https://doi.org/10.1016/j.jri.2012.10.007
Rashad NM, El-Shal AS, Abdelaziz AM. Association Between Inflammatory Biomarker Serum Procalcitonin and Obesity in Women With Polycystic Ovary Syndrome. J Reprod Immunol. 2013;97(2):232-9. PubMed PMID: 23218400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between inflammatory biomarker serum procalcitonin and obesity in women with polycystic ovary syndrome. AU - Rashad,Nearmeen M, AU - El-Shal,Amal S, AU - Abdelaziz,Ahmed M, Y1 - 2012/12/04/ PY - 2012/09/15/received PY - 2012/10/07/revised PY - 2012/10/15/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/9/21/medline SP - 232 EP - 9 JF - Journal of reproductive immunology JO - J Reprod Immunol VL - 97 IS - 2 N2 - Procalcitonin (PCT) is a potential biomarker of obesity-related, low-grade inflammation in polycystic ovary syndrome (PCOS). We aimed to investigate whether serum procalcitonin, high-sensitivity C-reactive protein (hs-CRP), white blood cell (WBC) and neutrophil counts are associated with polycystic ovary syndrome and with obesity. A case-control study included 107 women with PCOS and 93 healthy controls, they were then stratified according to their body mass index (BMI) into three subgroups; lean, overweight and obese. Serum PCT levels were measured using enzyme linked immunosorbent assay. PCOS patients had significantly higher levels of serum PCT, hs-CRP, WBC, and neutrophil counts than healthy women. In control and PCOS groups, serum PCT, hs-CRP levels, WBC, and neutrophil counts were significantly increased in overweight and obese women compared with lean subjects. Serum PCT levels were positively correlated with BMI, waist/hip ratio, total cholesterol, serum triglycerides, LH/FSH, hs-CRP values, WBC and neutrophil counts in PCOS women. We also observed that the increasing obesity was accompanied by a significant increase in the mean values of serum PCT and neutrophil counts in PCOS patients. We conclude that serum PCT is a novel biomarker for low-grade chronic inflammation in PCOS patients, especially in obese women. Thus, PCT is a promising useful marker for accurate diagnosis of the inflammatory activity of body fat and of PCOS. SN - 1872-7603 UR - https://www.unboundmedicine.com/medline/citation/23218400/Association_between_inflammatory_biomarker_serum_procalcitonin_and_obesity_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0378(12)00628-6 DB - PRIME DP - Unbound Medicine ER -