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Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model.
Food Chem Toxicol 2013; 53:105-11FC

Abstract

Protective effects of Tartary buckwheat (TB) and common buckwheat (CB) on amyloid beta (Aβ)-induced impairment of cognition and memory function were investigated in vivo in order to identify potential therapeutic agents against Alzheimer's disease (AD) and its associated progressive memory deficits, cognitive impairment, and personality changes. An in vivo mouse model of AD was created by injecting the brains of ICR mice with Aβ(25-35), a fragment of the full-length Aβ protein. Damage of mice recognition ability through following Aβ(25-35) brain injections was confirmed using the T-maze test, the object recognition test, and the Morris water maze test. Results of behavior tests in AD model showed that oral administration of the methanol (MeOH) extracts of TB and CB improved cognition and memory function following Aβ(25-35) injections. Furthermore, in groups receiving the MeOH extracts of TB and CB, lipid peroxidation was significantly inhibited, and nitric oxide levels in tissue, which are elevated by injection of Aβ(25-35), were also decrease. In particular, the MeOH extract of TB exerted a stronger protective activity than CB against Aβ(25-35)-induced memory and cognition impairment. The results indicate that TB may play a promising role in preventing or reversing memory and cognition loss associated with Aβ(25-35)-induced AD.

Authors+Show Affiliations

Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23219778

Citation

Choi, Ji Yeon, et al. "Tartary Buckwheat Improves Cognition and Memory Function in an in Vivo Amyloid-β-induced Alzheimer Model." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 53, 2013, pp. 105-11.
Choi JY, Cho EJ, Lee HS, et al. Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model. Food Chem Toxicol. 2013;53:105-11.
Choi, J. Y., Cho, E. J., Lee, H. S., Lee, J. M., Yoon, Y. H., & Lee, S. (2013). Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 53, pp. 105-11. doi:10.1016/j.fct.2012.11.002.
Choi JY, et al. Tartary Buckwheat Improves Cognition and Memory Function in an in Vivo Amyloid-β-induced Alzheimer Model. Food Chem Toxicol. 2013;53:105-11. PubMed PMID: 23219778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model. AU - Choi,Ji Yeon, AU - Cho,Eun Ju, AU - Lee,Hae Song, AU - Lee,Jeong Min, AU - Yoon,Young-Ho, AU - Lee,Sanghyun, Y1 - 2012/11/28/ PY - 2012/07/04/received PY - 2012/10/30/revised PY - 2012/11/01/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/8/27/medline SP - 105 EP - 11 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 53 N2 - Protective effects of Tartary buckwheat (TB) and common buckwheat (CB) on amyloid beta (Aβ)-induced impairment of cognition and memory function were investigated in vivo in order to identify potential therapeutic agents against Alzheimer's disease (AD) and its associated progressive memory deficits, cognitive impairment, and personality changes. An in vivo mouse model of AD was created by injecting the brains of ICR mice with Aβ(25-35), a fragment of the full-length Aβ protein. Damage of mice recognition ability through following Aβ(25-35) brain injections was confirmed using the T-maze test, the object recognition test, and the Morris water maze test. Results of behavior tests in AD model showed that oral administration of the methanol (MeOH) extracts of TB and CB improved cognition and memory function following Aβ(25-35) injections. Furthermore, in groups receiving the MeOH extracts of TB and CB, lipid peroxidation was significantly inhibited, and nitric oxide levels in tissue, which are elevated by injection of Aβ(25-35), were also decrease. In particular, the MeOH extract of TB exerted a stronger protective activity than CB against Aβ(25-35)-induced memory and cognition impairment. The results indicate that TB may play a promising role in preventing or reversing memory and cognition loss associated with Aβ(25-35)-induced AD. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23219778/Tartary_buckwheat_improves_cognition_and_memory_function_in_an_in_vivo_amyloid_β_induced_Alzheimer_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(12)00809-5 DB - PRIME DP - Unbound Medicine ER -