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Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies.
J Steroid Biochem Mol Biol 2013; 136:321-9JS

Abstract

Vitamin D metabolites enhance immunity to a wide range of respiratory pathogens in vitro. Numerous observational studies have investigated whether vitamin D deficiency is a risk factor for acute respiratory infection, and a number of clinical trials of vitamin D supplementation for the prevention of acute respiratory infection have recently been conducted. Syntheses of this literature are lacking. We therefore conducted a systematic review of clinical studies investigating the association between vitamin D deficiency and susceptibility to acute respiratory infection in humans. A total of 39 studies (4 cross-sectional studies, 8 case-control studies, 13 cohort studies and 14 clinical trials) satisfying review eligibility criteria were identified. Observational studies predominantly reported statistically significant associations between low vitamin D status and increased risk of both upper and lower respiratory tract infections. Results from randomised controlled trials were conflicting however, reflecting heterogeneity in dosing regimens and baseline vitamin D status in study populations. Further trials of vitamin D supplementation for the prevention of acute respiratory infection should be conducted in populations with a high prevalence of vitamin D deficiency at baseline, using doses sufficient to induce sustained elevation of serum 25-hydroxyvitamin D concentrations, and powered to detect clinically important sub-group effects. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

Authors+Show Affiliations

Queen Mary University of London, Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, London E1 2AB, UK. d.a.jolliffe@qmul.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

23220552

Citation

Jolliffe, David A., et al. "Vitamin D in the Prevention of Acute Respiratory Infection: Systematic Review of Clinical Studies." The Journal of Steroid Biochemistry and Molecular Biology, vol. 136, 2013, pp. 321-9.
Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. J Steroid Biochem Mol Biol. 2013;136:321-9.
Jolliffe, D. A., Griffiths, C. J., & Martineau, A. R. (2013). Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. The Journal of Steroid Biochemistry and Molecular Biology, 136, pp. 321-9. doi:10.1016/j.jsbmb.2012.11.017.
Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the Prevention of Acute Respiratory Infection: Systematic Review of Clinical Studies. J Steroid Biochem Mol Biol. 2013;136:321-9. PubMed PMID: 23220552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. AU - Jolliffe,David A, AU - Griffiths,Christopher J, AU - Martineau,Adrian R, Y1 - 2012/12/07/ PY - 2012/07/05/received PY - 2012/11/01/revised PY - 2012/11/28/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/8/31/medline SP - 321 EP - 9 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 136 N2 - Vitamin D metabolites enhance immunity to a wide range of respiratory pathogens in vitro. Numerous observational studies have investigated whether vitamin D deficiency is a risk factor for acute respiratory infection, and a number of clinical trials of vitamin D supplementation for the prevention of acute respiratory infection have recently been conducted. Syntheses of this literature are lacking. We therefore conducted a systematic review of clinical studies investigating the association between vitamin D deficiency and susceptibility to acute respiratory infection in humans. A total of 39 studies (4 cross-sectional studies, 8 case-control studies, 13 cohort studies and 14 clinical trials) satisfying review eligibility criteria were identified. Observational studies predominantly reported statistically significant associations between low vitamin D status and increased risk of both upper and lower respiratory tract infections. Results from randomised controlled trials were conflicting however, reflecting heterogeneity in dosing regimens and baseline vitamin D status in study populations. Further trials of vitamin D supplementation for the prevention of acute respiratory infection should be conducted in populations with a high prevalence of vitamin D deficiency at baseline, using doses sufficient to induce sustained elevation of serum 25-hydroxyvitamin D concentrations, and powered to detect clinically important sub-group effects. This article is part of a Special Issue entitled 'Vitamin D Workshop'. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/23220552/Vitamin_D_in_the_prevention_of_acute_respiratory_infection:_systematic_review_of_clinical_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(12)00250-6 DB - PRIME DP - Unbound Medicine ER -