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Chemotherapy modulates the biological activity of breast cancer patients plasma: the protective properties of black chokeberry extract.
Food Chem Toxicol 2013; 53:126-32FC

Abstract

In breast cancer patients (before and during anti-cancer therapy) oxidative/nitrative damage to various molecules is observed. Furthermore, anti-cancer treatments may also influence the hemostatic properties of blood platelets and plasma. The aim of our study was to assess the effect of oxidative/nitrative stress (estimated by measurements of the levels of carbonyl groups and 3-nitrotyrosine in proteins--ELISA and C-ELISA methods, respectively; lipid peroxidation and total antioxidant level--TAS) on the selected parameters of hemostatic activity of plasma (the process of fibrin polymerization and lysis) collected from breast cancer patients after surgery and after various phases of chemotherapy (doxorubicin and cyclophosphamide). Subsequently, we also evaluated the level of oxidative/nitrative stress and hemostatic activity in plasma from these patients in the presence of the commercial extract of Aronia melanocarpa (Aronox®) in vitro. Patients were hospitalized in Department of Oncological Surgery and Department of Chemotherapy in Medical University of Lodz, Poland. We observed increased levels of biomarkers of oxidative/nitrative stress in plasma from patients with breast cancer (before or after surgery and after various phases of chemotherapy) in comparison to healthy group. Our further experiments demonstrated the hemostatic activity of plasma from the investigated patients differs from hemostatic properties of plasma obtained from healthy volunteers. We also recognize the existence of a relationship between oxidative stress (measured by the level of carbonyl groups) and changes of hemostasis in breast cancer patients after I and IV phases of chemotherapy. Moreover, the obtained results showed that the commercial extract from A. melanocarpa berries significantly reduced, in in vitro system, the oxidative/nitrative stress and hemostasis changes in plasma from breast cancer patients, after surgery and different phases of chemotherapy. Considering the data presented in this study, we suggest that the oxidative/nitrative stress in plasma obtained from breast cancer patients (not only before or after the surgery, but also after various phases of doxorubicin and cyclophosphamide chemotherapy) may induce changes of hemostatic activity, which may contribute to thrombosis in these patients. Our results also suggest that the commercial extract of A. melanocarpa may be regarded as a promising new source of bioactive antioxidant natural compounds for breast cancer patients.

Authors+Show Affiliations

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/3, 90-236 Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23220617

Citation

Kędzierska, Magdalena, et al. "Chemotherapy Modulates the Biological Activity of Breast Cancer Patients Plasma: the Protective Properties of Black Chokeberry Extract." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 53, 2013, pp. 126-32.
Kędzierska M, Malinowska J, Kontek B, et al. Chemotherapy modulates the biological activity of breast cancer patients plasma: the protective properties of black chokeberry extract. Food Chem Toxicol. 2013;53:126-32.
Kędzierska, M., Malinowska, J., Kontek, B., Kołodziejczyk-Czepas, J., Czernek, U., Potemski, P., ... Olas, B. (2013). Chemotherapy modulates the biological activity of breast cancer patients plasma: the protective properties of black chokeberry extract. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 53, pp. 126-32. doi:10.1016/j.fct.2012.11.042.
Kędzierska M, et al. Chemotherapy Modulates the Biological Activity of Breast Cancer Patients Plasma: the Protective Properties of Black Chokeberry Extract. Food Chem Toxicol. 2013;53:126-32. PubMed PMID: 23220617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemotherapy modulates the biological activity of breast cancer patients plasma: the protective properties of black chokeberry extract. AU - Kędzierska,Magdalena, AU - Malinowska,Joanna, AU - Kontek,Bogdan, AU - Kołodziejczyk-Czepas,Joanna, AU - Czernek,Urszula, AU - Potemski,Piotr, AU - Piekarski,Janusz, AU - Jeziorski,Arkadiusz, AU - Olas,Beata, Y1 - 2012/12/05/ PY - 2012/09/14/received PY - 2012/11/23/revised PY - 2012/11/24/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/8/27/medline SP - 126 EP - 32 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 53 N2 - In breast cancer patients (before and during anti-cancer therapy) oxidative/nitrative damage to various molecules is observed. Furthermore, anti-cancer treatments may also influence the hemostatic properties of blood platelets and plasma. The aim of our study was to assess the effect of oxidative/nitrative stress (estimated by measurements of the levels of carbonyl groups and 3-nitrotyrosine in proteins--ELISA and C-ELISA methods, respectively; lipid peroxidation and total antioxidant level--TAS) on the selected parameters of hemostatic activity of plasma (the process of fibrin polymerization and lysis) collected from breast cancer patients after surgery and after various phases of chemotherapy (doxorubicin and cyclophosphamide). Subsequently, we also evaluated the level of oxidative/nitrative stress and hemostatic activity in plasma from these patients in the presence of the commercial extract of Aronia melanocarpa (Aronox®) in vitro. Patients were hospitalized in Department of Oncological Surgery and Department of Chemotherapy in Medical University of Lodz, Poland. We observed increased levels of biomarkers of oxidative/nitrative stress in plasma from patients with breast cancer (before or after surgery and after various phases of chemotherapy) in comparison to healthy group. Our further experiments demonstrated the hemostatic activity of plasma from the investigated patients differs from hemostatic properties of plasma obtained from healthy volunteers. We also recognize the existence of a relationship between oxidative stress (measured by the level of carbonyl groups) and changes of hemostasis in breast cancer patients after I and IV phases of chemotherapy. Moreover, the obtained results showed that the commercial extract from A. melanocarpa berries significantly reduced, in in vitro system, the oxidative/nitrative stress and hemostasis changes in plasma from breast cancer patients, after surgery and different phases of chemotherapy. Considering the data presented in this study, we suggest that the oxidative/nitrative stress in plasma obtained from breast cancer patients (not only before or after the surgery, but also after various phases of doxorubicin and cyclophosphamide chemotherapy) may induce changes of hemostatic activity, which may contribute to thrombosis in these patients. Our results also suggest that the commercial extract of A. melanocarpa may be regarded as a promising new source of bioactive antioxidant natural compounds for breast cancer patients. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23220617/Chemotherapy_modulates_the_biological_activity_of_breast_cancer_patients_plasma:_the_protective_properties_of_black_chokeberry_extract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(12)00849-6 DB - PRIME DP - Unbound Medicine ER -