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Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.
Am J Clin Nutr 2013; 97(1):208-16AJ

Abstract

BACKGROUND

The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity.

OBJECTIVE

The objective was to examine the interaction between IRS1 rs2943641 and macronutrient intakes on incident T2D and percentage body fat in the Malmö Diet and Cancer cohort.

DESIGN

The study included 15,227 women and 9614 men aged 45-74 y without prevalent diabetes. Dietary data were collected with a modified diet history method. During 12 y of follow-up, 1567 incident T2D cases were identified.

RESULTS

The T allele was associated with lower incidence of T2D (P-trend = 0.003) and, in men, with higher percentage body fat (P-trend = 0.00002). We observed 3-way interactions between sex, rs2943641, and carbohydrate intake (P = 0.01) as well as between sex, rs2943641, and fat intake (P = 0.01) on incident T2D. Among women, the T allele was associated with decreased risk only in the lower tertiles of carbohydrate intake (P-trend = 0.01, P-interaction = 0.01). In contrast, among men, the T allele was associated with decreased risk in the lowest tertile of fat intake (P-trend = 0.01, P-interaction = 0.02). No interaction was observed between macronutrient intakes and rs2943641 on percentage body fat.

CONCLUSIONS

Our results indicate that IRS1 rs2943641 interacts with carbohydrate and fat intakes on incident T2D in a sex-specific fashion. A protective association between the rs2943641 T allele and T2D was restricted to women with low carbohydrate intake and to men with low fat intake.

Authors+Show Affiliations

Department of Clinical Sciences in Malmö, Diabetes and Cardiovascular Disease, Genetic Epidemiology , Lund University, Malmö, Sweden. ulrika.ericson@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23221578

Citation

Ericson, Ulrika, et al. "Sex-specific Interactions Between the IRS1 Polymorphism and Intakes of Carbohydrates and Fat On Incident Type 2 Diabetes." The American Journal of Clinical Nutrition, vol. 97, no. 1, 2013, pp. 208-16.
Ericson U, Rukh G, Stojkovic I, et al. Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes. Am J Clin Nutr. 2013;97(1):208-16.
Ericson, U., Rukh, G., Stojkovic, I., Sonestedt, E., Gullberg, B., Wirfält, E., ... Orho-Melander, M. (2013). Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes. The American Journal of Clinical Nutrition, 97(1), pp. 208-16. doi:10.3945/ajcn.112.046474.
Ericson U, et al. Sex-specific Interactions Between the IRS1 Polymorphism and Intakes of Carbohydrates and Fat On Incident Type 2 Diabetes. Am J Clin Nutr. 2013;97(1):208-16. PubMed PMID: 23221578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes. AU - Ericson,Ulrika, AU - Rukh,Gull, AU - Stojkovic,Ivana, AU - Sonestedt,Emily, AU - Gullberg,Bo, AU - Wirfält,Elisabet, AU - Wallström,Peter, AU - Orho-Melander,Marju, Y1 - 2012/12/05/ PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/3/8/medline SP - 208 EP - 16 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 97 IS - 1 N2 - BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the interaction between IRS1 rs2943641 and macronutrient intakes on incident T2D and percentage body fat in the Malmö Diet and Cancer cohort. DESIGN: The study included 15,227 women and 9614 men aged 45-74 y without prevalent diabetes. Dietary data were collected with a modified diet history method. During 12 y of follow-up, 1567 incident T2D cases were identified. RESULTS: The T allele was associated with lower incidence of T2D (P-trend = 0.003) and, in men, with higher percentage body fat (P-trend = 0.00002). We observed 3-way interactions between sex, rs2943641, and carbohydrate intake (P = 0.01) as well as between sex, rs2943641, and fat intake (P = 0.01) on incident T2D. Among women, the T allele was associated with decreased risk only in the lower tertiles of carbohydrate intake (P-trend = 0.01, P-interaction = 0.01). In contrast, among men, the T allele was associated with decreased risk in the lowest tertile of fat intake (P-trend = 0.01, P-interaction = 0.02). No interaction was observed between macronutrient intakes and rs2943641 on percentage body fat. CONCLUSIONS: Our results indicate that IRS1 rs2943641 interacts with carbohydrate and fat intakes on incident T2D in a sex-specific fashion. A protective association between the rs2943641 T allele and T2D was restricted to women with low carbohydrate intake and to men with low fat intake. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23221578/Sex_specific_interactions_between_the_IRS1_polymorphism_and_intakes_of_carbohydrates_and_fat_on_incident_type_2_diabetes_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.046474 DB - PRIME DP - Unbound Medicine ER -