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Lyme disease: a multisystem infection that affects the nervous system.
Continuum (Minneap Minn). 2012 Dec; 18(6 Infectious Disease):1338-50.C

Abstract

PURPOSE OF REVIEW

This article will enable the reader to diagnose and treat nervous system Lyme disease appropriately.

RECENT FINDINGS

Appropriately applied serologic testing has high positive and negative predictive values in nervous system Lyme disease. Oral antibiotics can be curative in most cases.

SUMMARY

Infection with the tick-transmitted spirochete Borrelia burgdorferi causes Lyme disease, a disorder that involves the nervous system in about 15% of patients. Common manifestations include lymphocytic meningitis, cranial neuritis (particularly cranial nerve VII), painful radiculitis, other forms of mononeuropathy multiplex, and rarely CNS parenchymal involvement. Diagnosis is supported primarily by demonstration of anti-B. burgdorferi antibodies in serum. CSF examination can be informative in problematic cases with parenchymal CNS infection or to identify meningitis. However, oral antibiotics are probably effective in patients with meningitis and other forms of involvement, with the likely exception of parenchymal CNS infection.

Authors+Show Affiliations

Overlook Medical Center, Department of Neurosciences, 99 Beauvoir Ave, Summit, NJ 07902, USA. john.halperin@atlantichealth.org

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

23221844

Citation

Halperin, John J.. "Lyme Disease: a Multisystem Infection That Affects the Nervous System." Continuum (Minneapolis, Minn.), vol. 18, no. 6 Infectious Disease, 2012, pp. 1338-50.
Halperin JJ. Lyme disease: a multisystem infection that affects the nervous system. Continuum (Minneap Minn). 2012;18(6 Infectious Disease):1338-50.
Halperin, J. J. (2012). Lyme disease: a multisystem infection that affects the nervous system. Continuum (Minneapolis, Minn.), 18(6 Infectious Disease), 1338-50. https://doi.org/10.1212/01.CON.0000423850.24900.3a
Halperin JJ. Lyme Disease: a Multisystem Infection That Affects the Nervous System. Continuum (Minneap Minn). 2012;18(6 Infectious Disease):1338-50. PubMed PMID: 23221844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lyme disease: a multisystem infection that affects the nervous system. A1 - Halperin,John J, PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/5/11/medline SP - 1338 EP - 50 JF - Continuum (Minneapolis, Minn.) JO - Continuum (Minneap Minn) VL - 18 IS - 6 Infectious Disease N2 - PURPOSE OF REVIEW: This article will enable the reader to diagnose and treat nervous system Lyme disease appropriately. RECENT FINDINGS: Appropriately applied serologic testing has high positive and negative predictive values in nervous system Lyme disease. Oral antibiotics can be curative in most cases. SUMMARY: Infection with the tick-transmitted spirochete Borrelia burgdorferi causes Lyme disease, a disorder that involves the nervous system in about 15% of patients. Common manifestations include lymphocytic meningitis, cranial neuritis (particularly cranial nerve VII), painful radiculitis, other forms of mononeuropathy multiplex, and rarely CNS parenchymal involvement. Diagnosis is supported primarily by demonstration of anti-B. burgdorferi antibodies in serum. CSF examination can be informative in problematic cases with parenchymal CNS infection or to identify meningitis. However, oral antibiotics are probably effective in patients with meningitis and other forms of involvement, with the likely exception of parenchymal CNS infection. SN - 1538-6899 UR - https://www.unboundmedicine.com/medline/citation/23221844/Lyme_disease:_a_multisystem_infection_that_affects_the_nervous_system_ L2 - http://dx.doi.org/10.1212/01.CON.0000423850.24900.3a DB - PRIME DP - Unbound Medicine ER -