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CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22.
J Invest Dermatol. 2013 Apr; 133(4):973-9.JI

Abstract

Although CD4(+) T cells are known to contribute to the pathology of atopic dermatitis (AD) and psoriasis, the role of CD8(+) T cells in these diseases remains poorly characterized. The aim of this study was to characterize the cytokine production of T cells from AD and psoriasis skin. We found that CD4(+) T cells isolated from AD skin were largely Th2 (T helper type 2) biased, in agreement with prior reports. However, we also observed large numbers of CD8(+) T cells producing IL-13, IFN-γ, and IL-22. We observed increased numbers of CD8(+) T cells isolated from AD skin, and immunohistochemistry studies confirmed the presence of CD8(+) T cells in the dermis and epidermis of AD skin lesions. Surprisingly, T-cell cytokine production was similar in the lesional and nonlesional skin of patients with AD. T cells from psoriatic lesional skin predominantly produced IFN-γ, IL-17, and IL-22, in agreement with prior studies. However, in addition to Th17 cells, we observed high percentages of CD8(+) T cells that produced both IL-22 and IL-17 in psoriatic skin lesions. Our findings demonstrate that CD8(+) T cells are a significant and previously unappreciated source of inflammatory cytokine production in both AD and psoriasis.

Authors+Show Affiliations

Department of Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands. dirkjanhijnen@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23223131

Citation

Hijnen, Dirkjan, et al. "CD8(+) T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-γ, IL-13, IL-17, and IL-22." The Journal of Investigative Dermatology, vol. 133, no. 4, 2013, pp. 973-9.
Hijnen D, Knol EF, Gent YY, et al. CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. J Invest Dermatol. 2013;133(4):973-9.
Hijnen, D., Knol, E. F., Gent, Y. Y., Giovannone, B., Beijn, S. J., Kupper, T. S., Bruijnzeel-Koomen, C. A., & Clark, R. A. (2013). CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. The Journal of Investigative Dermatology, 133(4), 973-9. https://doi.org/10.1038/jid.2012.456
Hijnen D, et al. CD8(+) T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-γ, IL-13, IL-17, and IL-22. J Invest Dermatol. 2013;133(4):973-9. PubMed PMID: 23223131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. AU - Hijnen,Dirkjan, AU - Knol,Edward F, AU - Gent,Yoony Y, AU - Giovannone,Barbara, AU - Beijn,Scott J P, AU - Kupper,Thomas S, AU - Bruijnzeel-Koomen,Carla A F M, AU - Clark,Rachael A, Y1 - 2012/12/06/ PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/5/8/medline SP - 973 EP - 9 JF - The Journal of investigative dermatology JO - J. Invest. Dermatol. VL - 133 IS - 4 N2 - Although CD4(+) T cells are known to contribute to the pathology of atopic dermatitis (AD) and psoriasis, the role of CD8(+) T cells in these diseases remains poorly characterized. The aim of this study was to characterize the cytokine production of T cells from AD and psoriasis skin. We found that CD4(+) T cells isolated from AD skin were largely Th2 (T helper type 2) biased, in agreement with prior reports. However, we also observed large numbers of CD8(+) T cells producing IL-13, IFN-γ, and IL-22. We observed increased numbers of CD8(+) T cells isolated from AD skin, and immunohistochemistry studies confirmed the presence of CD8(+) T cells in the dermis and epidermis of AD skin lesions. Surprisingly, T-cell cytokine production was similar in the lesional and nonlesional skin of patients with AD. T cells from psoriatic lesional skin predominantly produced IFN-γ, IL-17, and IL-22, in agreement with prior studies. However, in addition to Th17 cells, we observed high percentages of CD8(+) T cells that produced both IL-22 and IL-17 in psoriatic skin lesions. Our findings demonstrate that CD8(+) T cells are a significant and previously unappreciated source of inflammatory cytokine production in both AD and psoriasis. SN - 1523-1747 UR - https://www.unboundmedicine.com/medline/citation/23223131/CD8_+__T_cells_in_the_lesional_skin_of_atopic_dermatitis_and_psoriasis_patients_are_an_important_source_of_IFN_γ_IL_13_IL_17_and_IL_22_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)36191-1 DB - PRIME DP - Unbound Medicine ER -