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A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease.
JPEN J Parenter Enteral Nutr 2013; 37(4):517-28JJ

Abstract

BACKGROUND

Hyperinsulinemia and altered lipid and lipoprotein metabolism induced by fast-food diets may contribute to nonalcoholic fatty liver disease (NAFLD). We hypothesized that a high saturated fat (SFA) meal would evoke prolonged postprandial lipemia and hyperinsulinemia, increased inflammation, and altered lipoprotein expression in obese children with NAFLD when compared with healthy children.

METHODS

We prospectively studied 31 children (NAFLD, 13.1 ± 2.6 years, n = 11; age-matched obese, 14.3 ± 1.7 years, n = 9; lean, 13.6 ± 2.6 years, n = 11) following consumption of a high SFA (18.8%) meal. Prior to and at 1, 3, and 6 hours after meal consumption, blood was collected for analysis of alanine aminotransferase (ALT); aspartate aminotransferase (AST); γ-glutamyltransferase; leptin; C-reactive protein; (fasting) insulin; glucose; triglycerides (TGs); total, high-density lipoprotein, and low-density lipoprotein cholesterol; adiponectin; nonesterified fatty acids (NEFAs); inflammatory markers (TNF-α, IL-6, IL-10); apolipoproteins-B48, B100, and CIII; and fatty acid (FA) composition of TG fractions.

RESULTS

Children with NAFLD had significantly higher fasting levels of ALT (87 ± 54 U/L), AST (52 ± 33.5 U/L), and apolipoprotein-CIII (20.6 ± 11.3 mg/dL) with postprandial hyperinsulinemia (iAUC insulin: 225 ± 207 [NAFLD] vs 113 ± 73 [obese] vs 47 ± 19.9 [lean] mU/L-h; P < .001); suppression of NEFA (iAUC-NEFA: 1.7 ± 0.9 [NAFLD] vs 0.6 ± 0.3 [obese] vs 1 ± 0.7 [lean] mEq/L-h); and prolonged elevations in apolipoprotein-B48 3-6 hours after meal consumption when compared with obese and lean controls (P < .05).

CONCLUSION

A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without NAFLD.

Authors+Show Affiliations

Department of Agriculture, Food, and Nutritional Science, 4-126 Li Ka Shing Centre for Research Innovation, University of Alberta, Edmonton, AB T6G OK2, Canada. mager@ualberta.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23223552

Citation

Mager, Diana R., et al. "A Meal High in Saturated Fat Evokes Postprandial Dyslipemia, Hyperinsulinemia, and Altered Lipoprotein Expression in Obese Children With and Without Nonalcoholic Fatty Liver Disease." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 37, no. 4, 2013, pp. 517-28.
Mager DR, Mazurak V, Rodriguez-Dimitrescu C, et al. A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease. JPEN J Parenter Enteral Nutr. 2013;37(4):517-28.
Mager, D. R., Mazurak, V., Rodriguez-Dimitrescu, C., Vine, D., Jetha, M., Ball, G., & Yap, J. (2013). A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease. JPEN. Journal of Parenteral and Enteral Nutrition, 37(4), pp. 517-28. doi:10.1177/0148607112467820.
Mager DR, et al. A Meal High in Saturated Fat Evokes Postprandial Dyslipemia, Hyperinsulinemia, and Altered Lipoprotein Expression in Obese Children With and Without Nonalcoholic Fatty Liver Disease. JPEN J Parenter Enteral Nutr. 2013;37(4):517-28. PubMed PMID: 23223552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease. AU - Mager,Diana R, AU - Mazurak,Vera, AU - Rodriguez-Dimitrescu,Carla, AU - Vine,Donna, AU - Jetha,Mary, AU - Ball,Geoff, AU - Yap,Jason, Y1 - 2012/12/05/ PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2014/1/18/medline KW - children KW - lipid KW - lipoprotein KW - nonalcoholic fatty liver disease KW - postprandial SP - 517 EP - 28 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 37 IS - 4 N2 - BACKGROUND: Hyperinsulinemia and altered lipid and lipoprotein metabolism induced by fast-food diets may contribute to nonalcoholic fatty liver disease (NAFLD). We hypothesized that a high saturated fat (SFA) meal would evoke prolonged postprandial lipemia and hyperinsulinemia, increased inflammation, and altered lipoprotein expression in obese children with NAFLD when compared with healthy children. METHODS: We prospectively studied 31 children (NAFLD, 13.1 ± 2.6 years, n = 11; age-matched obese, 14.3 ± 1.7 years, n = 9; lean, 13.6 ± 2.6 years, n = 11) following consumption of a high SFA (18.8%) meal. Prior to and at 1, 3, and 6 hours after meal consumption, blood was collected for analysis of alanine aminotransferase (ALT); aspartate aminotransferase (AST); γ-glutamyltransferase; leptin; C-reactive protein; (fasting) insulin; glucose; triglycerides (TGs); total, high-density lipoprotein, and low-density lipoprotein cholesterol; adiponectin; nonesterified fatty acids (NEFAs); inflammatory markers (TNF-α, IL-6, IL-10); apolipoproteins-B48, B100, and CIII; and fatty acid (FA) composition of TG fractions. RESULTS: Children with NAFLD had significantly higher fasting levels of ALT (87 ± 54 U/L), AST (52 ± 33.5 U/L), and apolipoprotein-CIII (20.6 ± 11.3 mg/dL) with postprandial hyperinsulinemia (iAUC insulin: 225 ± 207 [NAFLD] vs 113 ± 73 [obese] vs 47 ± 19.9 [lean] mU/L-h; P < .001); suppression of NEFA (iAUC-NEFA: 1.7 ± 0.9 [NAFLD] vs 0.6 ± 0.3 [obese] vs 1 ± 0.7 [lean] mEq/L-h); and prolonged elevations in apolipoprotein-B48 3-6 hours after meal consumption when compared with obese and lean controls (P < .05). CONCLUSION: A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without NAFLD. SN - 1941-2444 UR - https://www.unboundmedicine.com/medline/citation/23223552/A_meal_high_in_saturated_fat_evokes_postprandial_dyslipemia_hyperinsulinemia_and_altered_lipoprotein_expression_in_obese_children_with_and_without_nonalcoholic_fatty_liver_disease_ L2 - https://doi.org/10.1177/0148607112467820 DB - PRIME DP - Unbound Medicine ER -